"Artron Complex" is a combination drug with pronounced chondroprotective properties, which are aimed at stimulating regenerative and slowing down degenerative processes in cartilage tissues.
Pharmacological forms and composition
The manufacturer produces the drug in a single pharmacological form. These are tablets that are coated.
The composition of the drug contains two active substances: chondroitin sulfate in an amount of 500 mg and glucosamine hydrochloride in an amount of 500 mg.
Pharmacological effects
"Arthron Complex" is a combination agent that has the properties of a chondroprotector. Against the background of its intake, the processes of cartilage tissue regeneration are stimulated, which allows to improve joint mobility, increase the range of movements, and reduce the pain that accompanies almost every disease affecting the musculoskeletal system.
The medication can stimulate the production of synovial fluid, prevent the onset and progression of a disease such as osteoporosis, have a positive effect on articular tissues and slow down degenerative changes affecting bone tissue.
If the patient takes NSAIDs in parallel with the indicated drug, a slowdown in metabolic damage and changes in cartilage tissue is observed.
According to the instructions to the "Artron Complex", the mechanism of action of the active components in the drug is due to their ability to activate the synthesis of proteoglycans and collagen of the second type. Glucosamine hydrochloride has an anti-inflammatory effect. Chondroitin sulfate is able to normalize the mineralization of the bone system, improve recovery processes after fractures.
With a single dose of chondroitin sulfate in an amount of 500 mg, its maximum concentration in plasma is noted after 4 hours, in the joint fluid - after 5 hours. Moreover, the concentration of the active component in the synovial fluid is significantly higher than in the blood. However, the bioavailability of the drug reaches only 15%. Excretion of metabolites is carried out during the day through the urinary system.
The bioavailability of the second active substance - glucosamine hydrochloride - is about 26%. It is very well distributed over the tissues of the body, and its highest concentration is noted in the tissues of cartilage, liver and kidneys.
As a result of metabolism, carbon dioxide, urea and water are formed. About 30% of the used dose persists in connective tissue. Excretion is carried out partially with feces (through the intestines), but mainly together with urine (through the kidneys).
Indications for use
Arthron Complex tablets are recommended for use in the following cases:
- Postoperative recovery after bone fractures or surgical procedures on the musculoskeletal system.
- In order to restore cartilage tissue.
- In order to eliminate severe pain in athletes and the elderly, which develops against the background of joint damage.
- With periodontopathy, chondropathy, osteopathy.
- With spondylarthrosis, osteoarthritis, osteochondrosis and other diseases that are degenerative in nature and affecting bones and joints.
Glucosamine contained in the medicinal product promotes the regeneration of the surface of cartilage, stimulates the formation of aminoglycans. Under its influence, the influence of chondroitin sulfate is enhanced, which is aimed at normalizing the formation of synovial fluid, reducing pain, improving joint mobility.
Contraindications
Artron Complex should not be used:
- In the presence of hypersensitivity to any of the components that are part of the drug.
- With diagnosed decompensated diseases of the kidneys and liver.
- With phenylketonuria.
- With a tendency to bleeding.
- With thrombophlebitis.
- With diabetes.
Using
The tablets of this medication are intended for oral use. They should be swallowed whole, not allowing crushing or chewing. It is necessary to drink plenty of water with water. The treatment regimen and the necessary dosages should be determined by the doctor individually, depending on the state of health of a particular patient.
It is recommended to take the drug in courses, the duration of which is an average of 3 months. Adult patients are prescribed one tablet, which must be taken 1-3 times a day. If the desired therapeutic effect is obtained before the end of the course of treatment, a reduction in the frequency of doses to one per day is allowed.
Negative impact
Against the background of the use of the drug, various systems and organs of the body can respond with the development of negative consequences, such as:
- Edema, maculopapular rash, dermatitis, erythema, hypersensitivity, itching, urticaria from the immune system.
- Fatigue, general weakness, drowsiness, insomnia, headaches, dizziness from the side of the National Assembly.
- Flatulence, vomiting, constipation, stomach pain, diarrhea, dyspepsia, nausea from the gastrointestinal tract.
- Swelling, hair loss, visual disturbances.
Currently, cases of overdose, accompanied by intoxication and the development of clinical symptoms, are not registered.
Special instructions for use
It is strictly forbidden to exceed the dosage recommended by the doctor and violate the prescribed treatment regimen.
One of the active components that are part of the drug is glucosamine, which is obtained by processing shellfish shells. Accordingly, patients with allergic reactions to mollusks need to take the drug with extreme caution.
Special studies to study the effect of a medical device on a person’s ability to drive vehicles and work with potentially dangerous equipment have not been conducted. However, the list of negative reactions that occur while taking the drug includes visual impairment, dizziness, drowsiness. This should be taken into account when carrying out work that requires a person to have quick reactions and an increased concentration of attention.
In accordance with the instructions for use of "Artron Complex", the appointment of the drug to pregnant women is not allowed. If there is an urgent need to use the drug for the treatment of breast-feeding women, then breast-feeding should be stopped.
At present, there is not enough information confirming the safety of the effect of the active components of the drug on pediatric patients. In this regard, it should not be used for the treatment of children under 15 years of age.
Like any other chondroprotective agent, Arthron Complex is contraindicated in patients suffering from severe renal impairment.
It is forbidden to use the medication for patients with diagnosed severe liver diseases.
Interaction with other medicines
The parallel use of the specified drug with chloramphenicol or penicillin derivatives reduces the absorption of the latter.
With simultaneous use with tetracyclines and tetracycline derivatives, an increase in the absorption of the latter is observed.
The impact of the "Artron Complex" may be enhanced by the influence of vitamin and mineral preparations.
The medication is able to enhance the effect of NSAIDs and glucocorticosteroids, in connection with which their simultaneous administration involves dose adjustment.
Analogues of the "Artron Complex"
Currently, pharmaceuticals offer several drugs whose therapeutic effect is similar to the medication we are describing. The most popular are Structum, Chondroitin Complex, Mucosat, Chondroxide, Teraflex, Artra, Glucosamine-Chondroitin.
"Arthra" is a synthetic drug used for long-term treatment of osteoarthritis. The drug promotes the regeneration of cartilage, alleviates the symptoms of the disease, and has a moderate anti-inflammatory effect.
It is used in the treatment of osteoarthrosis of the spine and peripheral joints. Contraindications: severe renal impairment, hypersensitivity to the components of the tablets.
If it is necessary to replace with another drug, it is important to consult a specialist who will determine the feasibility of such a replacement.
Cost and reviews
The average cost of the "Artron Complex" in Moscow varies at the level of 2,000 rubles for one package containing 60 tablets.
The reviews left by patients who used the specified medication allow us to conclude its effectiveness in the case of eliminating the pain syndrome and increasing the amplitude of movements of the injured joints. Separately, in reviews about the "Artron Complex" it was noted that the drug is practically safe, well tolerated, practically does not cause negative effects.
Patients believe that the negative quality of the drug is that in order to achieve the desired effect, it should be taken for a rather long time. Also, its rather high cost is attributed to the minuses.
The best results from therapy will be achieved if you combine the use of the remedy with physiotherapy and physiotherapeutic procedures.
It is important to remember that the appointment of the drug and the determination of the treatment regimen should be carried out by the doctor. This will eliminate possible contraindications, avoid side effects, achieve the desired effect.
We have reviewed the instructions and reviews for Arthron Complex.