The drug "Gliformin" belongs to the group of biguanides. This is a hypoglycemic medication that reduces glucose absorption and at the same time increases the sensitivity of some tissues to insulin. From the materials in this article you will find out at what dosage Gliformin is prescribed for diabetes mellitus, the cost of the drug and reviews of real patients.
Composition and form of release
The drug goes on sale in the form of tablets, which can be of two types:
- Flat cylindrical pills with a white chamfer (0.5 g of active substance). 10 pieces are packaged in cell packages.
- Pills in a film shell cream shade (0.85 or 1 g of active substance). 60 pieces are packaged in polypropylene cans.
The active substance is metformin hydrochloride.
pharmachologic effect
Glyformin for diabetes should be taken exclusively orally. The mechanism of action of the drug on the systems of internal organs is not fully understood.
Penetrating into the body, the active active substance is involved in the following processes:
- Suppression of the formation of glucose molecules in the liver.
- Activation of the breakdown of carbohydrates.
- Reducing the amount of glucose from the intestines.
The use of the drug "Glyformin" for diabetes and obesity entails a decrease in appetite and body weight. The instructions indicate that the medication promotes the gradual dissolution of blood clots and prevents platelet adhesion.
Metformin hydrochloride is rapidly absorbed by the cells of the digestive tract. The maximum concentration of active active substance is fixed after two hours from the moment of administration. Its bioavailability is approximately 50-60%. The medication does not come into contact with plasma proteins, gradually accumulates in the systems of internal organs. From the body, the substance is excreted almost unchanged.
Indications for the use of the drug "Gliformin"
Tablets for use recommends taking the patients with the following pathologies:
- Type II diabetes mellitus, when diet therapy and sulfonylurea preparations are ineffective.
- Type I diabetes mellitus (in addition to standard insulin therapy).
During treatment, constant monitoring of the kidneys is necessary, once every six months it is recommended to check the lactate in the blood plasma.
Mode of application
At what dosage is Gliformin prescribed for diabetes? According to the instructions, the tablets should be taken during / after meals, while they must be washed down with water. The specific dosage and duration of the course of treatment is prescribed by the doctor, taking into account the patient’s blood glucose values.
At the initial stage of therapy (first 15 days), the dosage is not more than 1 g per day. Then it is gradually increased. The maintenance dose usually does not exceed 2 g per day. It is evenly divided into several receptions.
For elderly patients, the daily dose of the drug is not more than 1 g.
Side effects
When a doctor prescribes "Gliformin" for diabetes, reviews of real patients can evaluate the effectiveness of the drug. Like other medicines, it can cause a number of side effects:
- Endocrine system: hypoglycemia.
- Blood circulation: anemia.
- Allergic reactions: rashes, urticaria.
- Metabolism: hypovitaminosis.
- Gastrointestinal system: lack of appetite, nausea, taste of metal in the mouth, vomiting, diarrhea.
If adverse reactions occur, it is necessary to refuse taking the tablets for some time and consult a doctor.
Contraindications
The instructions for the drug say that its administration is not recommended in the following conditions:
- diabetic coma ;
- ketoacidosis;
- pulmonary / heart failure;
- chronic liver disease;
- myocardial infarction;
- hypersensitivity to the components of the drug;
- pregnancy and lactation.
With extreme caution, you should use "Glyformin" from diabetes mellitus in pathologies of an infectious nature, before serious operations.
Drug interaction
According to the instructions, with simultaneous use with insulin, non-steroidal anti-inflammatory drugs, sulfonylureas, beta-blockers, an increase in the effect of Glyformin is not ruled out.
Its effectiveness can significantly decrease against the background of additional treatment with glucocorticosteroids, oral contraceptives, thyroid hormones, nicotinic acid derivatives, diuretics.
Price and storage conditions
The medication should be stored at temperatures up to 25 degrees in a place protected from children. Shelf life is 3 years, and for tablets in a film coating - 2 years.
How much does Gliformin cost? In diabetes, the price of drugs plays an important role for many patients. The medication described in the article is relatively inexpensive. For the packaging of tablets in a film coating will have to pay a little more than 300 rubles. Pills with a separation chamfer (0.5 g of active substance) are cheaper - about 150 rubles.
Analogs
When the drug "Glyformin" is purchased, use, instructions, reviews - this is the first thing that patients pay attention to. Due to the wide range of contraindications, the medication is not suitable for many. You can choose a drug similar in pharmacological properties after consulting a doctor.
Among the analogues that most correspond to Gliformin in terms of the content of the active substance, the following are distinguished: Diaberite, Metformin, Glucoran.
Reviews of patients and doctors
Many patients who have been prescribed this drug for treatment report a high probability of an overdose. In most cases, it is due to improper use of the medication. An overdose can provoke the occurrence of the so-called lactic acidosis. Its main symptoms are: muscle pain, vomiting and nausea, impaired consciousness. If the patient has such symptoms, it is recommended to stop taking the medication and seek help from a doctor.
On the part of specialists, reviews in most cases are positive. That is why Glyformin is so often prescribed for diabetes. The price of the medicine is low, it can be purchased at almost every pharmacy. If you carefully follow the instructions, the likelihood of side effects is low. Doctors warn that throughout the course of treatment it is necessary to undergo testing for serum creatinine content 2-3 times a year. During therapy, alcohol and taking medications containing ethanol should be discarded.
To summarize
Diabetes mellitus is a fairly common disease, which today is increasingly being diagnosed in young people. For his treatment, doctors prescribe various medications. “Glyformin” also refers to them. This is a hypoglycemic medication that is responsible for increasing the sensitivity of tissues to insulin. If you take it in accordance with the instructions and as prescribed by your doctor, there should be no side effects. It is equally important to consider the contraindications of the drug.