What are the properties of the drug "Tobrex"? Reviews about this drug will be presented later. We will also tell you about what indications and contraindications this remedy has, how it should be used correctly, whether it has side effects and so on.
Description, packaging and composition of the drug
What are Tobrex eye drops? Experts say that they go on sale in the form of a clear, colorless or yellowish solution in special dropper bottles with the possibility of dosing (5 milliliters each). Each bottle is placed in a cardboard package that has a blue and blue pattern.
What does the Tobrex medication contain? Reviews of experts note that the composition of this solution includes such an active substance as tobramycin. As auxiliary components, the preparation contains benzalkonium chloride, purified water, boric acid, tilaxopol, sodium sulfate and sodium hydroxide.
Pharmacological action of the drug
How do Tobrex drops work? Reviews of experts indicate that the drug in question is an antibiotic that acts on a wide range of pathogens. It belongs to the group of aminoglycosides.
In low concentrations, the drug exhibits a bacteriostatic effect (it suspends protein synthesis and inhibits the 30S subunit of ribosomes).
In high concentrations, the drug is able to change the permeability of cell membranes, thereby causing cytolysis. Thus, it exhibits a pronounced bactericidal effect.
Drug properties
According to the spectrum of its action, the active substance of the drug is very similar to Gentamicin. However, it is more active against gentamicin-resistant strains. In this regard, the drug in question is often used with the ineffectiveness of neomycin-containing drops.
Tobramycin fights well with various infections. However, it is ineffective against certain strains of streptococci, which belong to group D.
Pharmacokinetics
Is the Tobrex drug (eye drops) absorbed? Reviews of specialists inform us that with topical application there is no absorption of this drug into the systemic circulation.
Indications for use
In what cases can Tobrex drops be prescribed to children? Reviews of pediatricians say that such a drug is often used to treat infectious and inflammatory lesions of the eyes and surrounding tissues.
Thus, the following diseases are indications for the use of the said agent:
- conjunctivitis;
- blepharoconjunctivitis;
- blepharitis;
- keratitis;
- keratoconjunctivitis;
- iridocyclitis.
In addition, this drug can be prescribed for barley (meibomite), as well as for the prevention of complications that occurred before and after ophthalmic interventions.
Contraindications
What are the contraindications of the drug "Tobrex"? Reviews of doctors say that this tool can not be used only with individual hypersensitivity to the components of the drug.
The drug "Tobrex" (eye drops), instructions
Patient reviews about this drug are mixed. In order to avoid side effects and overdoses before using this tool, we recommend that you read the instructions or consult a doctor.
So how should I use the drug "Tobrex"? Instructions, reviews of experts say that it must be instilled in one drop four or five times a day.
It should be especially noted that in addition to the Tobrex medication, you can also find drops such as Tobrex 2X in pharmacies. These funds differ only in the frequency of administration. The drug "Tobrex 2X" is recommended to instill one drop two or three times a day.
The differences of the mentioned funds in the frequency of use are due to the fact that the second medication has a thicker consistency. This feature allows the active substance of the drug to stay longer in the conjunctival sac. In this regard, the frequency of its use is reduced without affecting the therapeutic effect.
The course of treatment with the considered drug should be seven to ten days.
If necessary, Tobrex eye drops can be instilled every 60 minutes. However, after eliminating the symptoms, one should return to the above scheme.
For the best therapeutic effect at night, the Tobrex ointment should be additionally used.
Overdose
With the incorrect use of the drug in question, as well as with its accidental ingestion, almost no symptoms of poisoning are manifested. Although experts claim that in some cases, signs of an overdose of this medicine can be very similar to its side effects. In such a situation, it is recommended to rinse thoroughly with warm water.
Adverse reactions
What side effects can the Tobrex medication (eye drops) cause? Reviews of experts say that in 1.5% of cases, allergic reactions are detected in patients, which are manifested by itching, conjunctival redness and lacrimation.
In 1% of cases, patients have redness and swelling of the eyelids, swelling of the conjunctiva, as well as general discomfort in the eye area.
In 0.5% of cases, patients were diagnosed with chemosis (i.e. conjunctival edema), keratitis (inflammation of the cornea), as well as blepharitis (inflammation of the edges of the eyelids), single ulcerations and pains in the eyes.
With prolonged therapy, a manifestation of fungal superinfection is possible.
Drug interaction
The simultaneous use of the drug "Tobrex" with the following means should be excluded:
- "Furosemide" or ethacrylic acid (an ototoxic effect is noted).
- “Carboplatin”, “Capreomycin”, “Cepepim”, “Teicoplanin” and “Cefotaxim” (nephro- and ototoxic effects are noted).
- “Vancomycin” (nephro-, oto- and neurotoxic effects are observed).
- “Amphotericin”, “Cefaperazone”, “Cifamandol”, “Cefuroxime” (nephrotoxic effect is manifested).
It should also be noted that the drug in question cannot be used simultaneously with drugs that have tetracycline in their composition (due to the content of tyloxapol in Tobrex drops).
special instructions
An unreasonable increase in the frequency and duration of the use of the drug can lead to the appearance of bacteria that are insensitive to the substances of the drug, including fungal infections of the eyes. If signs of superinfection occur, consult a doctor immediately.
Childhood
Is it possible to prescribe the drug "Tobrex" for children? Reviews of experts inform us that this tool is actively used in pediatric practice. It is used for children aged one year and older.
Is Tobrex prescribed for newborns? Reviews of manufacturers indicate that this tool is safe and effective for infants suffering from conjunctivitis. As a rule, such patients are prescribed five times the use of the drug within a week.
Lactation and pregnancy
A small amount of data on the use of Tobrex eye drops by pregnant women does not allow specialists to draw objective conclusions about the toxicity of the drug. In this regard, during the period of bearing the fetus from its use should be abstained.
In addition, there are absolutely no studies that confirm the ingestion of a drug in breast milk. In this case, one cannot exclude the risk for a baby who is breastfeeding. In this regard, lactation should be stopped during treatment.
Analogs and price of the drug
The preparations "Tobrex 2X", "Tobrimed" and "Tobrosopt" are complete analogues of the drug in question (in terms of composition and form of release). In Russia, the price of this tool varies between 150-220 rubles. You can buy it at any pharmacy without a doctor’s prescription.
Patient Reviews
Currently, there are quite a lot of reviews about the medication in question. In general, they are positive. Patients are satisfied that after a short course of treatment, the drug produces a pronounced therapeutic effect.
A large number of people who were prescribed this medication, especially often note that in the process of its use, they almost never have adverse reactions.
It should also be noted that patients can not but rejoice at the low price of eye drops. One bottle is enough for a full course of treatment, which is quite cheap. By the way, there is evidence that this tool is very effective when used as nasal drops for rhinitis.
As for the negative reviews, they are not very many. Some patients claim that this remedy is generally ineffective in the above diseases. Experts attribute this to the fact that each person is unique, and the same drugs can affect different people in different ways.
Be healthy!