In the article, we consider the instructions for the Trental tablets.
This is a vasodilating agent, through which blood circulation improves, its fluidity is restored.
This drug improves blood microcirculation in the area where there are defects in circulatory disorders.
The active substance of the drug affects deformed red blood cells and inhibits platelet aggregation. This process is carried out simultaneously with the expansion of the coronary vessels.
Trental tablets are prescribed only by a specialist after carrying out the necessary diagnostic procedures. It is necessary to correctly calculate its dosage and eliminate all possible contraindications. Thanks to a qualified approach to treatment, cerebral circulation can be restored.
Instructions for use of the drug
The pharmacological effect of Trental is based on the improvement of blood microcirculation and angioprotective effect.
If the drug is taken systemically, this improves the blood rheology. The consequence of these processes is the oxygen saturation of the soft tissues of the body.
The absolute indications for using Trental are as follows:
- ischemic stroke and encephalopathy;
- various kinds of circulatory disorders;
- gangrene, frostbite and trophic ulcers;
- angioneuropathy;
- damage to the retina of the eyes and blood vessels;
- respiratory tract diseases;
- defects in metabolic processes in the inner ear;
- vascular impotence.
The active active ingredient in the composition of the drug reduces the likelihood of thrombosis, since it does not allow platelets to adhere excessively. Due to this, blood circulation in small blood vessels is normalized.
In addition to other functions, Trental tablets reduce the amount of fibrogens that affect blood viscosity. As a result of this, erythrocyte cell membranes improve, their resistance increases significantly.
The active component also has relaxing functions, positively affecting the walls of blood vessels.
Such processes are accompanied by a decrease in resistance, as well as an increase in the volume of blood that enters the systems and organs of the body.
Achieving a healing effect is observed one hour after taking the tablets. The active substance is neutralized in the liver, its residues are excreted through the urinary system.
I must say that the breakdown products of the drug also fully have a beneficial therapeutic effect on the human body.
Product release form and composition
The drug is produced in the following forms:
- tablets - one piece contains 100 milligrams of pentoxifylline;
- sustained release tablets - one piece contains 400 milligrams of the active ingredient.
There is also a concentrate for the preparation of the solution - one milliliter of it contains no more than twenty milligrams of pentoxifylline. But in this article we will not consider it.
In the form of auxiliary components, Trental tablets include sodium hydroxide, lactose, magnesium stearate and starch. The concentrate contains, in addition to the active substance, sodium chloride. Long-acting tablets contain talc, povidone, hyetellose, and magnesium stearate.
Due to excipients, adverse reactions can also develop after treatment. It is important to get expert advice before that, who will select an effective and safe dosage taking into account the characteristics of the body.
Useful signs
The benefit of the drug is maximum if the dosage is prescribed correctly and there are no contraindications for use. In each situation, an individual dosage of the drug is necessary.
The standard treatment regimen involves taking Trental tablets two to four at least twice a day. Every day you need to drink the drug after eating, drinking plenty of water. Its maximum daily amount should not be higher than 1200 milligrams.
Excellent tolerability of the drug is noted when administered intravenously. The dosage in this case is determined by the severity of the pathological process in the body, drug tolerance and patient weight.
There are special recommendations for the use of the drug:
- with low blood pressure and defects in kidney activity, low dosages are prescribed, which increase over time;
- in special cases, intravenous injections of five milliliters are administered;
- in case of liver failure, the dosage of the drug is selected individually for the patient.
If a severe form of heart rhythm interruptions is observed, careful monitoring is necessary. Severe type of coronary heart disease and cerebral stenosis require treatment that begins with small doses, and their further increase.
This is confirmed by the instructions for use with Trental tablets.
Unwanted effects
The appearance of unwanted symptoms is possible with all forms of medication. With a high rate of intravenous administration or when taking large doses, there is an increased likelihood of the following side effects:
- defects of the nervous system, which are accompanied by headache, excessive excitability, dizziness and convulsions;
- allergic manifestations on the skin in the form of hyperemia, flushing and edema;
- disorders of the digestive system, characterized by intestinal atony, the development of anorexia and xerostomia;
- defects in the activity of the heart and vascular system, manifested in the form of tachycardia, arrhythmia and cardialgia;
- malfunctions of the hemostatic system and hematopoietic function, which is accompanied by high bleeding of the mucous membranes, leukopenia and pancytopenia;
- aseptic meningitis rarely develops.
Contraindications
To avoid the occurrence of side effects after the use of Trental tablets 100 mg or 400 mg, you can not use the drug if there are contraindications.
Therapy should not be carried out with the acute nature of myocardial infarction, massive bleeding, hemorrhagic stroke. The drug is absolutely contraindicated during pregnancy, hemorrhage in the eye retina, breastfeeding.
With uncontrolled arterial hypotension, atherosclerosis and arrhythmias, the administration of the drug is not allowed intravenously.
Treatment with the drug is not allowed for minors.
Because of the drug, serious unwanted effects and defects in the activity of internal organs and body systems can develop.
Overdose
When using large doses of Trental tablets, from 400 mg and above, the following reactions may appear:
- Disorders of the gastrointestinal tract (feeling of “clogging” or pressure of the stomach, diarrhea, vomiting).
- Rush of blood to the face (fever, redness).
- Redness of the skin, urticaria, itching.
- Sweating, cramps, chills.
- Anxiety, sleep disturbances, dizziness.
Quite rarely: anaphylactic reactions, tachycardia, angina pectoris, low blood pressure, bleeding (intestinal, from the vessels of the skin, mucous membranes). Isolated cases of the occurrence of aseptic meningitis and intrahepatic cholestasis are observed. This is stated in the instructions for use.
Trental 100 mg tablets should also be taken with caution.
Interaction with other drugs
The medication is not recommended to be arbitrarily used simultaneously with other drugs. An obligatory measure of safe and successful treatment is a preliminary consultation with your doctor.
The combined use of other drugs contributes to the appearance of undesirable consequences.
"Cimetidine" increases the likelihood of side effects due to an increase in the content of the active substance in the blood.
Thrombolytics increase blood coagulation, which is why the effectiveness of Trental decreases.
Pentoxifylline increases the effectiveness of Trental, which greatly reduces blood pressure.
special instructions
When applying, it is necessary to carefully monitor the condition of patients with arrhythmia, high blood pressure, impaired renal and hepatic activity, diabetes mellitus, and excessive bleeding. In this case, the maximum permissible daily norm is selected, which begins with a small dosage. Otherwise, side symptoms may occur.
Analogs
Trental has structural analogues with a similar active component. These include: Agapurin, Flexital, Radomin, Arbiflex, Trenpental, Pentamon.
Trental Tablet Reviews
Among the positive characteristics stand out: quick and tangible effect; improving the condition of the body as a whole; elimination of numbness of the arms and legs; improved blood circulation; the drug is indispensable for systemic lupus erythematosus; the tool is universal in the treatment of many diseases in the vascular system. Negative reviews: side effects may occur. In this case, the dosage should be selected based on the individual characteristics of the body. There are cheaper and more affordable counterparts.
Usually the use of Trental tablets is well tolerated by patients. Undesirable effects are often the result of non-compliance with medical recommendations and improper dosing.