In the article, we consider the dosage and instructions for the suspension "Augmentin 400".
It is a combined antibiotic of a wide spectrum of effects, it is used for the treatment of infectious bacterial diseases of the respiratory canals with bronchitis, bronchopneumonia and pneumonia. The medicine is effective for treating otolaryngological organs (otitis media, sinusitis, tonsillitis, pharyngitis), subcutaneous tissue (abscesses, phlegmon, cellulitis, wounds), the genitourinary system (cystitis, urethritis, pyelonephritis, salpingitis, vaginitis, gonorrhea, endometritis). It is also used against sepsis, osteomyelitis and peritonitis. In addition, for adults and children, the suspension "Augmentin 400" according to the instructions is used for the prevention and treatment of infections after surgery.
Forms of drug release
Currently, this tool is available in three varieties. In our article, we will talk about the Augmentin 400, which is a powder for the preparation of a suspension. All types of drugs are commercial variants of the same antibiotic with absolutely equal effects, rules of use and indications. The only difference between the existing commercial varieties of the drug is the dosage of its active component and the format of release (pills, suspension, powder for injection).
These differences make it possible to choose the best option for a medical medicine in each case. For example, if an adult is unable to swallow tablets for some reason, then he will be able to use the suspension. Usually, the types of medication are simply called Augmentin. And for clarification, a dosage designation is added, for example, "Augmentin suspension 400".
Structure
As the instructions for the Augmentin 400 suspension indicate, it contains two substances as active ingredients, namely amoxicillin and clavulanic acid. Amoxicillin is an antibiotic belonging to the category of penicillins, it has a wide spectrum of effects and is detrimental to a large number of pathogenic bacteria that cause infectious pathologies of various organs and systems. In addition, amoxicillin is well tolerated and rarely provokes side effects, which makes it safe and approved for use even among pregnant women.
True, the Augmentin suspension (400 mg) has one drawback, which is that resistance to amoxicillin in many pathogenic bacteria forms after a few days of use, since microbes begin to produce special substances that destroy the antibiotic. This drawback is limited to its use in the treatment of bacterial infections. True, this minus is eliminated by clavulanic acid, which is the second component of the drug. This ingredient is a special substance that inactivates the lactamases produced by bacteria and therefore makes amoxicillin highly effective even against microbes that were previously insensitive to its effects. Instructions for use with the suspension "Augmentin" (400 mg) confirms this.
Clavulanic acid makes amoxicillin effective against bacteria that are resistant to it, which significantly increases the spectrum of use of this combination drug.
Dosage
So, according to the instructions, the suspension "Augmentin 400" contains two active ingredients. In this regard, the dosage of the drug is indicated not by one number, but by two, for example 400 milligrams + 57 and so on. The first figure, of course, indicates the amount of the antibiotic itself - amoxicillin, and the second, respectively, speaks of clavulanic acid. But you should know that the calculation of the dosage of "Augmentin" always occurs according to the concentration of amoxicillin.
The dosage of the Augmentin preparation was calculated per 5 ml, that is, after the suspension is prepared, exactly in this quantity (and not 1 milliliter) of the resulting solution will contain 400 milligrams of amoxicillin.
In accordance with the instructions, the use of the suspension "Augmentin 400" for children is indicated. Therefore, the drug is often called children's. The suspension is also available in dosage of 125 and 200 mg.
What else does the instructions for the Augmentin 400 suspension tell us?
Therapeutic effects
The medication has only one therapeutic effect, that is, antibacterial, since it has a detrimental effect on a wide range of different pathogenic microbes that cause infectious and inflammatory diseases of the genitourinary and respiratory system, subcutaneous tissue, as well as osteomyelitis, peritonitis and sepsis. Thus, the medicine destroys bacteria that provoke infections of these organs and, accordingly, they cure infectious and inflammatory diseases.
As indicated by the instructions for use with the Augmentin suspension (400 mg), the presence of clavulanic acid in the drug makes it highly effective, as it allows you to expand the spectrum of exposure to amoxicillin and makes it effective against bacteria that, when isolated, use this antibiotic, are resistant to it .
The instruction and dosage of the Augmentin 400 suspension for children and adults must be strictly observed.
Indications for use of the suspension
The drug in the form of a suspension is used in the short-term treatment of infections that are caused by microbes sensitive to this antibiotic:
- Use in relapsing or acute otitis media.
- Application for tonsillopharyngitis and sinusitis.
- Treatment of lobar pneumonia and bronchopneumonia.
- Therapy of infections of the skin and soft tissue (for cellulite, abscess, phlegmon, boils, panniculitis, infected wounds).
A doctor should prescribe a medication.
General admission rules
Let us consider in more detail the instructions for the suspension "Augmentin 400" for children and adults.
Before treatment with a suspension, the required amount of the drug is measured using a special measuring cap or a syringe with divisions. The suspension is taken orally, a measured amount is swallowed from the cap. Babies who for some reason are not able to drink a clean suspension, it is recommended to dilute it with water in a ratio of one to one, after pouring the necessary volume of the drug into a glass from a measuring cap. After use, rinse the syringe or cap with clean water.
This is stated in the instructions for use for the suspension "Augmentin 400" for children.
In order to reduce discomfort and side effects from the digestive system, it is recommended to take a suspension at the beginning of eating. Admission should be made after equal time intervals. For example, if you want to take the medicine twice a day, you must maintain the same twelve-hour interval. When you need to take the medicine three times, you should do this every eight hours, trying to comply with the specified interval. The minimum allowable course of using the suspension "Augmentin 400" according to the instructions (dosage must be observed) is five days. This means that you can not be treated with the drug for less than five days.
The maximum allowable duration of use without repeated examinations, as a rule, is two weeks. That is, after the diagnosis is established without a second examination, you can use the drug for no more than two weeks. In the event that during the course of treatment a repeated examination was carried out, revealing a positive, but at the same time slow healing dynamics, then, based on these results, the duration of admission can increase to three or even four weeks. If necessary, you can carry out step therapy, which consists in the consistent use of the drug inside.
In the instructions, the dosage of the Augmentin 400 suspension for children and adults is described in detail.
The choice of dosage form for children and adults
Regardless of the severity of the infectious pathology, adult patients and children over twelve years of age who have a body weight of more than forty kilograms should take the drug in question only in the form of tablets or suspensions with a dosage of 400 milligrams. This dosage form with a lower dosage, for example, 125 or 200 mg, is not recommended for patients of this category, since the amount of clavulanic acid and amoxicillin in them, taking into account the rate of excretion and distribution of the drug, is not balanced.
Children under twelve or those weighing less than forty kilograms should take 5 ml of the Augmentin 400 suspension. Babies under three months of age can only be treated with the same dosage form with a dosage of 125 mg. Small patients who are older than three months of age are allowed to use this type of medicine with any dosage of active ingredients.
Recipe suspension "Augmentin 400"
This drug format is prepared in full before first use. You can’t divide the powder in a bottle into several dosages and gradually dilute it, getting a smaller amount of medication. That is, all the powder that is in the bottle must be diluted at a time, and then during the course of therapy for each dose, the required number of milliliters is measured. Crushing the drug leads to inaccurate dosage, and at the same time to an uneven distribution of active substances. This causes the ineffectiveness of the drug prepared from one half of the medicinal powder. How to dilute the suspension "Augmentin 400"? It is prepared as follows:
- In a bottle containing powder, add 60 milliliters of chilled boiled water (the volume of water can be measured with a syringe).
- Spin the lid of the bottle and shake it vigorously until the powder is dissolved.
- Next, put the product for five minutes on a flat surface.
- In the event that insoluble particles of powder are collected at the bottom after this, you must again shake the vessel and again put it on the surface for five minutes.
- When, after five minutes of settling, no particles of medicine remain on the bottom, open the lid, and then add chilled water to the indicated mark.
The finished suspension is stored in the refrigerator (but it can not be frozen) for one week, after which all residue that has not been used should be discarded. When the course of treatment lasts for more than seven days, then after a week of storage, it is necessary to discard the remains of the old solution and prepare a new one.
Suspension "Augmentin 400": instructions for use for children
The finished medicine should be stored in the refrigerator for a maximum of a week. In the event that the reception is required to be made for more than one week, then the remnants of the old drug that was stored in the refrigerator should be discarded on the eighth day and a new portion prepared. Before use, the dosage of the Augmentin 400 suspension for children should be accurately calculated.
Immediately before each reception, shake the bottle with the medication and only after that gain the necessary volume using the measuring cap or an ordinary syringe with division. After each use, the syringe and cap should be rinsed with clean water. The suspension needs to be drunk directly from the cap or it is pre-poured into a small container, for example, a glass.
Suspension, which was collected in a syringe, is recommended to pour into a spoon or into a glass. In the event that for some reason it is difficult for a child to swallow a pure medicine, then the measured volume for a single dose can additionally be diluted with water in a ratio of one to one. In this case, it is immediately impossible to dilute the powder with twice as much water. Dilute the medication immediately before each use and only the amount that is needed for one use.
The dosage of Augmentin 400 in each specific situation is calculated individually according to body weight, severity of the child’s disease and his age. In this case, as we have already said, in the framework of the calculations, only amoxicillin is taken, the second component is neglected. It should be remembered that children under three months of age should be given a suspension with a dose of 125, and not 400 milligrams. And for those older than three months, they are given this form of medication with any dosage of active ingredients.
Recommended dosage:
- from 25 mg / kg / day to 45 mg / kg / day, divided into 2 doses, for mild and moderate infections (recurrent tonsillitis, infections of the skin and soft tissues);
- from 45 mg / kg / day to 70 mg / kg / day, divided into 2 doses, for the treatment of more serious infections (otitis media, sinusitis, lower respiratory tract infections).
Babies younger than three months should calculate the daily dosage based on the ratio of 30 milligrams of amoxicillin per kilogram of weight. The received daily dose is divided into two and given to the child twice a day every twelve hours.
Is Augmentin 400 suspension suitable for adults? About this - below.
For adults
The specified dosage of the suspension "Augmentin 400" for adults with low body weight is suitable, weight - from forty-five kilograms. Otherwise, this kind of medication is more suitable for treating a child and is considered a children's form of medication.
special instructions
In accordance with the instructions for the suspension "Augmentin" (400 mg), people who are in old age, do not need to adjust the dosage of this medicine. Patients who suffer from liver diseases must, throughout the entire period of use of the Augmentin 400 agent, monitor the performance of this body.
Before using the drug in question, it is necessary to make sure that a person does not have any allergic reactions to antibiotics of the cephalosporin and penicillin categories. In the event that during the period of use of the medication there is any allergic reaction, the use of the drug should be stopped immediately and never be used again. You can not be treated with Augmentin 400 in case of suspected infectious mononucleosis.
When using the medicine in high doses, at least 2 liters of fluid per day should be consumed so that a large number of crystals are not formed in the urine that can scratch the urethra during urination. When using the product, be sure to brush your teeth several times a day in order to prevent staining. The instructions for the suspension "Augmentin" (400 mg) are very detailed.
Impact on machinery management
It is worth noting that the medication in patients is able to provoke dizziness. In this regard, it is recommended that during the course of treatment the drug under consideration refuse to control all kinds of mechanisms, including driving cars.
How to take a suspension of Augmentin 400 in conjunction with other medicines?
Interaction with other medicines
With the simultaneous use of the drug in question with indirect anticoagulants (be it Warfarin, Thrombostop, and so on), it is imperative to check the INR, as it may change. In such a case, it is necessary to adjust the dosage of anticoagulants for the period of their simultaneous use with Augmentin 400.
It should be borne in mind that the drug "Probenecid" can lead to an increase in the concentration of the described drug in the blood. The Allopurinol agent against the background of simultaneous administration with Augmentin 400 may increase the risks of developing all kinds of undesirable skin reactions. The drug increases the toxicity of methotrexate and reduces the effectiveness of oral combined contraceptives. Therefore, against the background of the use of the drug, additional contraceptive methods should be used.
If the dosage of the Augmentin suspension (400 mg) is not observed, complications may develop.
Overdose
An overdose of the drug in question in humans is quite possible and can manifest itself in various malfunctions of the digestive system, impaired electrolyte concentration, and dehydration. , .
Side effects
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Contraindications
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Analogues of the drug
In the modern pharmaceutical market, there is a fairly wide range of various synonyms for Augmentin, which also contain clavulanic acid with amoxicillin as active ingredients. These medicines are called analogues in the active ingredient. The following medications are such substitutes for the described drug for the active substance:
- Amovikomb in powder form for the preparation of injectable solutions.
- The medicine "Amoxivan", which is also produced in the form of a powder for the preparation of therapeutic solutions.
- A medication called Amoxiclav. This substitute is supplied to the pharmaceutical market in the form of tablets and suspensions.
- Amoxiclav Quicktab is a dispersible drug tablet.
- Tablets "Arlet" and "Bactoclav".
- The medicine "Verklav", which is produced in the form of a powder for the preparation of a solution for intravenous administration.
- The drug "Clamosar" is sold in the form of a suspension.
- Means "Liklav" for injection.
- Medoclav medicine is supplied to the market in the form of tablets and powder for internal use.
- Panklav and Ranklav preparations in the form of medical pills.
- Fibell powder for solution for injection.
- Tablets Flemoklav Solyutab and Ekoklav.
Next, we find out that people write about this antibiotic in their reviews.
Reviews
About eighty percent of reviews on Augmentin 400 suspensions on the Internet are positive, due to the effectiveness of this medication in treating a person’s infection. In almost all comments, consumers indicate a rather high efficiency of the medication in question, due to which it is possible to achieve a quick cure for infectious diseases.
True, along with a statement of the effectiveness of the drug, people also often indicate the occurrence of side effects, which very often turn out to be extremely unpleasant or poorly tolerated. For example, people mostly complain of headaches, nausea, insomnia, and anxiety.
Actually, the presence of certain adverse reactions is the basis for most of the negative comments that are regularly left, even despite the general effectiveness of this medicine.
What is the price of Augmentin 400 ml suspension?
Cost
The cost of various forms of the described medication in the pharmacies of Russian cities can vary within the following limits:
- For a suspension of Augmentin with a dosage of 125 milligrams, you need to pay 160 rubles.
- For a drug with a dosage of 200 milligrams, you will have to pay 300 rubles.
- A medication containing 400 milligrams of the main active substance will cost 450 rubles.
Can I give this medication to children?
Why is Augmentin 400 Suspension suitable for children?
The drug has been used in the treatment of babies for a decade and a half. Moreover, scientists note that during this time, pathogenic microscopic organisms have not adapted to the medication. That is, this means that the effectiveness of the drug has not decreased. This tool can give very good results in the process of destroying the main pathogens of bronchopulmonary pathologies in children.
The medication includes, as already known, two whole active components in the form of amoxicillin and clavulanic acid. Both ingredients can get into sputum in a matter of minutes, gathering in the bronchi and starting there their activity of cleansing the body. Thanks to this particular chemical composition, Augmentin 400 is able to cure diseases of the respiratory system much faster than conventional drugs. Already three days later, immediately after the start of taking the drug, ninety percent of babies undergo chest pain in case of pneumonia. In addition, temperature is normalized in seventy-two percent of children, and breathing is greatly facilitated in seventy-four.
Even in the treatment of chronic bronchitis, which is at the stage of exacerbation, in small patients, Augmentin 400 gives better results compared to other drugs used for the same purpose. Based on clinical trials, many researchers recommend the use of Augmentin 400 as the main therapeutic component in the treatment of bronchopulmonary pathologies in children.
In this regard, parents in vain doubt the permission to use this antibiotic to treat their child. The drug in question has another advantage over other drugs. It is an affordable price. Due to the fact that the action of the drug occurs faster, therapy costs them much cheaper at home, as well as in a hospital.
This medicine demonstrates a sufficiently high efficiency in the treatment of middle ear inflammation, sinusitis and chronic tonsillitis in babies. Many inflammatory processes in the urinary tract in children are provoked by microscopic organisms that are sensitive only to the combination of an antibiotic and clavulanic acid. It is in this connection that Augmentin 400 is prescribed for the treatment of these diseases.
Thus, the considered drug is an antibiotic of a fairly wide area of use. The medicine "Augmentin" acts as a combined medication containing an effective penicillin antibiotic that produces an antimicrobial effect. Such a medication is very effective against all kinds of pathogenic bacteria. Clavulanic acid as a component of this drug perfectly ensures the resistance of amoxicillin to the effects of lactamases, increasing its scope.