The clinical and pharmacological category to which the Omez preparation belongs is antiulcer drugs. As a rule, manufacturers release the medicine in the form of hard transparent gelatin capsules. The inscription “OMEZ” is printed on both sides of the capsules, and the trademark of the manufacturer can also be located. The weight of one capsule is 20 milligrams. Capsules are in strips of 10 pieces each and are packed in cardboard boxes.
The active substance of the drug is omeprazole. Under this name, the drug is registered in the INN. In addition, some manufacturers produce the drug under this name. Excipients in the capsule are mannitol, lactose, purified talc, titanium dioxide, gelatin, sodium hydroxide, lauryl sulfate and hydrogen phosphate, sucrose.
The pharmacological effect of the drug "Omez" instructions for use are described as follows. This antiulcer drug has the ability to inhibit ATPase in gastric cells and thereby helps to block the final stage of the hydrochloric acid synthesis process. Thus, a decrease in the amount of stimulated secretion occurs. In this case, the source of the formation of the stimulus does not matter.
After administration, omeprazole begins to act quickly (approximately within an hour), and its effect lasts throughout the day.
The greatest effect of the drug is "Omez", the instruction determines the period two hours after administration.
If a medicine is prescribed to treat a duodenal ulcer, the active substance provides a level of intragastric pH-3 units for seventeen hours at a dose of 20 mg. The restoration of secretory activity occurs within three to five days.
The pharmacokinetic properties of the drug "Omez", the instruction describes as follows. Absorption of the main active ingredient of omeprazole is characterized by the ability to be absorbed quite quickly from the digestive tract. After about half an hour or an hour, the Cmax value in the blood reaches its maximum value. The bioavailability of the drug "Omez" is about 30-40%.
The medicine "Omeprazole" has the property of interacting well with plasma proteins. The binding rate is up to 90%. At the same time, this drug is almost completely metabolized in the liver cells.
The half-life of the drug is equal to half an hour to an hour, and excretion is carried out mainly by the kidneys. It should be borne in mind that in case of chronic renal failure, the rate of excretion of the components of the drug decreases in proportion to the rate of decrease in QC. The bioavailability of the drug is higher in elderly patients, and the rate of excretion of substances is lower. In the case of the use of the drug by patients with liver failure, the half-life is three hours, and the bioavailability reaches 100%.
The drug "Omez" instructions for use recommend taking without chewing, just the capsule should be washed down with a small amount of water.
The dose of administration when prescribing patients with a duodenal ulcer is 1 capsule with a duration of administration of 2-4 weeks (for a chronic type of disease). In resistant cases, a dose increase of up to 40 mg is allowed - this is 2 capsules per day.
For the treatment of gastric ulcers, as well as erosive-ulcerative esophagitis, the dose is 1-2 capsules per day, and the period of administration is 4-8 weeks. The duration of administration in cases of gastrointestinal tract lesions of an erosive-ulcerative nature is 4-8 weeks with a maximum daily dose of 20 mg.
In case of an overdose, symptoms such as blurred vision, dry mouth, and nausea are observed. Arrhythmia, confusion, and increased arousal are extremely rare.
In the treatment with Omez, the contraindications are as follows: it should not be prescribed to children, as well as women during pregnancy or breastfeeding. Before use, you should carefully familiarize yourself with the composition of the drug and exclude the possibility of side effects with hypersensitivity to its components.
The drug "Omez" is recommended to be stored at a temperature not exceeding 25 ° C. The medicine is suitable for use subject to storage rules for 3 years. The drug is sold exclusively by prescription.