Drops for eyes âBetaxololâ (instructions for use classify them as selective beta-adrenoblockers of long action) are actively used in ophthalmic practice, and tablets are widely used in the treatment of a number of cardiovascular diseases.
Release form and composition
Betaxolol is available in the form of tablets and eye drops. One white film-coated tablet contains 20 mg of the active component of betaxolol hydrochloride. Additional ingredients are: sodium carboxymethyl starch, magnesium stearate, microcrystalline cellulose, lactose monohydrate, aerosil. The composition of the shell contains: polyvinyl alcohol, white opadrai-2, macrogol, talc, titanium dioxide.
Packed in 10 pieces in aluminum blisters of Betaxolol tablets. Instructions for use are enclosed in a cardboard box.
In eye drops, 1 ml accounts for 5.6 mg of the active component of betaxolol hydrochloride. Minor substances in the composition of the drug are: sodium hydroxide, benzethonium chloride, hydrochloric acid, disodium edetate dihydrate, sodium chloride, water. It is a yellowish crystalline substance. The solution is enclosed in a dropper bottle (5 or 10 ml). A dropper tube with a dosage of 1.5-5 ml is also available. In a cardboard pack put instructions and a dropper bottle.
Shelf life and shelf life
The shelf life of drugs (tablets and eye drops) is three years. After opening the drops, the bottle can be stored no more than twenty-eight days.
Pharmacokinetics
The pharmacological effect of the drug is characterized by beta-adrenergic blocking selective, antianginal, antihypertensive, antiarrhythmic, anti-glaucoma orientation.
It blocks beta1-adrenergic receptors, has no sympathomimetic activity, and is also distinguished by small membrane-stabilizing properties. It reduces the susceptibility of tissues to catecholamines, slows down central impulse, and stops the secretion of renin. Reduces heart rate and reduces myocardial oxygen consumption (antianginal properties). Blocks emerging ectopic foci in the atria, AV combinations.
The result is observed two hours after administration, and the maximum concentration of the drug in the body is fixed after 3-4 hours and lasts for 12-24 hours, normalizes with constant use of the drug for 7-14 days. Protects against increased blood pressure during physical exertion and psychological stress.
Treatment of high blood pressure occurs by reducing the mass of the left ventricular myocardium and increasing its contractile function. About 75% of patients with mild or moderate hypertension respond well to such monotherapy. Prolonged use of the drug does not affect lipid metabolism and sodium excretion. In people with asthma and chronic bronchitis, it does not reduce the function of external respiration.
Drops for eyes âBetaxololâ (instructions for use indicate the effect of the drug on reducing intraocular pressure by reducing intraocular fluid) do not cause side effects such as hemeralopia, myosis, accommodation spasm and veil before the eyes.
The effect is achieved half an hour after application, the maximum concentration is observed after two hours and lasts for twelve hours.
Indications for use
It is recommended to take Betaxolol tablets with a diagnosis of arterial hypertension, a transient attack of myocardial ischemia (exertional angina), akathisia provoked by antipsychotics.
Eye drops (instructions for use advises to consult a doctor before using them) are indicated for cases of open-angle glaucoma, intraocular hypertension. Doctors prescribe the drug after laser trabeculoplasty. Used for prolonged hypotensive therapy, the need for which arose due to surgical ophthalmic intervention.
Medical contraindications
Despite the proven effectiveness of the drug âBetaxololâ (the instructions for the use of the drug recommend that you strictly observe the doses prescribed by the doctor and not self-medicate), its use has certain contraindications. These include hypersensitivity to the active component of the medication and additional substances in its composition. It is also prohibited if sinus bradycardia (less than 45-50 beats / min) and weakness of the sinus node are fixed. You can not use the medicine with AV blockade of the II-III degrees, arterial hypotension. Betaxolol is contraindicated for people with cardiogenic shock, patients with severe heart failure and severe obstructive respiratory failure.
Caution should be taken with chronic pneumonia, patients with unstable angina, predisposition to bradycardia. Alertness should cause AV blockade of I degree, interruptions in peripheral circulation. Patients with diabetes mellitus, hypoglycemia, liver and kidney diseases, and hyperthyroidism should be especially careful. Doctors should monitor the medication in patients with muscle weakness, in the elderly and children.
During pregnancy and lactation, the drug is taken if the expected benefit to the mother outweighs the potential risk to the fetus. For the duration of therapy, you should stop breast-feeding.
"Betaxolol": instructions for use
Price, reviews, composition - these are the positive aspects of the medicine that make patients choose it again and again.
Tablets should be drunk in the morning. With hypertension, dragees are taken once, starting with a dose of 10 mg. If after a week the desired effect is not obtained, then the dose is increased to 20 ml. If the expected result again could not be achieved, then after 7-14 days the dose is increased to 40 mg.
Patients with impaired renal function, receiving dialysis, as well as older people should take the medicine in an amount of 5 mg once. If necessary, the dose can be increased every 14 days by 5 mg. Recommends not to exceed the maximum dose - 20 ml of the drug "Betaxolol" - instructions for use.
Abstract advises the use of eye drops for glaucoma. Instillation should be carried out strictly in the conjunctival sac. A single dose is equal to one drop. This event is held twice a day. During the first month of treatment, the doctor should monitor the intraocular pressure of the patient.
Side effects
He claims that the use of the drug âBetaxololâ can lead to side effects, the instructions for use. The price of the medicine is affordable, which makes it affordable for all segments of the population (80 rubles for a 5 ml bottle and 370 rubles for 30 tablets).
During treatment with Betaxolol, chronic fatigue and headache, dizziness, drowsiness, sleep disturbance, anxiety, and depression can occur. The concentration of attention decreases, nightmares, hallucinations, amnesia, neuralgia, vestibular disturbances torment.
In some patients, impotence and impaired urination, pain in the chest (in women), prostatitis, fibrocystic changes were noted. There was an upset digestion, diarrhea, dry mouth, nausea, vomiting, constipation, and abdominal pain. The drug sometimes negatively affects infectious diseases of the lungs, dyspnea, causes chest pain, pharyngitis, rhinitis, sinusitis. Fixed bronchospasm, shortness of breath, respiratory failure.
Among the side effects, the following were also identified: bradycardia, hypotension, myocardial infarction, heart failure, leukocytosis, thrombocytopenia, purpura and other diseases. Arthralgia, tendonitis, myalgia were rare enough.
There may be a rash, alopecia, allergic reactions, eczema, weight loss, erythema, hypothermia, exacerbation of psoriasis, hypertrichosis, prurigo.
The use of eye drops can cause lacrimation, dry eyes, blurred vision, photophobia, keratitis, erythema, foreign body sensation in the eye, corneal sensitivity, anisocoria, and photophobia.
special instructions
During therapy with Betaxolol (the instructions for use describe in detail the dose and method of treatment), a change in laboratory tests is often observed. This can be a false positive reaction to doping, an increase in the titer of antinuclear antibodies, etc.
Overdose of the drug "Betaxolol"
Instructions for use (analogues have the same active substance and have a similar effect) strongly recommends observing the dosage. Otherwise, you may encounter such unpleasant symptoms:
- dizziness;
- disruption of the cardiovascular system;
- bronchospasm;
- decrease in blood glucose;
- muscle cramps;
- collapse.
In this case, classic treatment is prescribed according to the following scheme:
- gastric lavage;
- the use of absorbent substances;
- symptomatic therapy - atropine intravenously 1-2 mg, beta-adrenergic agonists, sedatives, cardiotonic drugs;
- transvenous stimulation (prescribed only in emergency cases).
About Precautions
Therapy should be carried out only under medical supervision. During treatment, you may not notice the initial stage of thyrotoxicosis and hypoglycemia. This is especially true for patients with diabetes. Compensatory processes of the heart and blood vessels decrease. Do not use the drug before surgery.
Regular use of the drug by older people increases the likelihood of hypothermia, an unstable mental state, and a violation of cardiovascular activity. Patients with kidney and liver disease should be monitored by a physician for the first four days. With an allergic history there is a chance of an increase in hypersensitivity and a decrease in the therapeutic effect of adrenaline.
When using the drug, it is forbidden to take alcoholic beverages. Also, you can not abruptly stop the therapy, but you need to do it slowly, by reducing the dose for two weeks. Advises caution to drivers when using the drug "Betaxolol" instructions for use.
Price, analogues of the drug
If the drug does not fit, then the attending physician can always offer an analog, which often differs only in price. So, Betaxolol tablets and drops cost about 80-370 rubles. Analogues of tablets include:
- "Betak" (Cyprus), costs about 300 rubles for 20 tablets.
- Lokren (France), the price for 28 tablets is 600-700 rubles, and for 56 pills - 1000-1200 rubles.
Eye drops with the active substance betaxolol hydrochloride can be replaced with the following drugs:
- Betalmik EU (Slovakia), 160-200 rubles.
- âBetopticâ (Belgium, USA), about 300 rubles.
- âBetoptic Sâ (Belgium, USA), within 300 rubles.
- Betoftan (Romania), 200 rubles.
- Xonef (India), 180 rubles.
- âXonef BKâ (India), about 150 rubles.
- Optibetol (Poland).
Talks about the effectiveness of treatment of arterial hypertension with the drug "Betaxolol" instructions for use. Price, reviews (analogues are more expensive, but the effect on the body is the same) - all this information is presented in the article.
Patient opinions
Recommended use in ophthalmic therapy drops "Betaxolol" instructions for use. The price (reviews say that this is one of the advantages of the drug) is low, and therefore almost anyone in need of treatment can buy them. Many patients emphasize the good tolerance of eye drops. They say that they do not cause side effects. The result is visible by the end of the first week.
With the help of tablets, people control blood pressure. The drug helps to reduce the burden on the heart, improves the general condition of patients. Some stress the digestive upset in the early days of taking the pills. There are people in whom the drug caused allergies, rashes, and redness on the skin. Someone notes nausea and severe arrhythmia.
Most of the reviews about the drug are positive, patients were satisfied with such therapy.