Means "Propofol" describes the instructions for use as a drug specifically designed for non-inhalation anesthesia. After direct administration, this medicine is distributed in tissues in a very short time and undergoes biotransformation in the liver with the formation of so-called inactive conjugates. In this case, the state of anesthesia occurs only thirty to forty seconds after the administration of the drug. The action of the Propofol agent (the instructions for use explains this by the properties of the active component) is based on the nonspecific effect on the lipids of the membrane tissue of neurons of the nervous system, as a result of which the ion channels malfunction. It should be especially noted that this drug has practically no analgesic effect, and the restoration of all body functions after the termination of its effect occurs very quickly.
Propofol is available (instructions for use are always included) in the form of an emulsion for infusions containing a substance such as propofol as the main component. Auxiliary elements are glycerin, soybean oil, sodium hydroxide, egg lecithin and purified water.
Specialists recommend using Propofol anesthesia mainly as an effective short-term anesthesia. In addition, this drug is excellent for maintaining a sedative effect in those patients who are in intensive care wards and are connected to mechanical ventilation devices . Instructions for use also advise prescribing the Propofol agent for organizing introductory and maintaining general anesthesia. Among other things, this drug is well suited for sedation while maintaining the patient's consciousness. The latter is especially important during various diagnostic and surgical procedures.
The manufacturer categorically prohibits the use of this tool if the patient has an allergic reaction to propofol or is individually intolerant of any other substances presented in the composition.
In addition, this drug should not be used to organize maintenance anesthesia and induction anesthesia in children under three years of age. Women who bear a child are also prohibited from prescribing the propofol drug. Reviews also indicate its undesirable use in the lactation period. The drug "Propofol" is strictly contraindicated for sedation in children and adolescents with epiglottitis or croup and undergoing appropriate intensive care.
If we talk about the main adverse reactions that can be caused by the use of this drug, then in the first place, a rather high risk of pain at the injection site should be highlighted. In addition, bradycardia, arterial hypotension, dizziness, headache, vomiting, and nausea may occur.