The drug, belonging to the clinical and pharmacological group of antibacterial fluoroquinolones, Nolicin tablets are coated, have an orange color, biconvex, round, with a notch on one side.
Norfloxacin, the active substance, contains 400 mg per tablet. Of the auxiliary, the following are present:
- talc;
- sodium starch glycolate;
- titanium dioxide;
- povidone;
- hydroxypropyl methylcellulose;
- propylene glycol;
- magnesium stearate.
The antimicrobial drug "Nolitsin", the instruction of which contains information on the indications, has a wide scope. This includes various infectious inflammatory diseases that are caused by microorganisms that are sensitive to the drug. Namely, such infections:
- genitals;
- urinary tract;
- gastrointestinal tract;
- gonococcal;
- traveler's diarrhea. The drug is also prescribed as a preventive measure against syphilis.
Practice shows the high activity of the drug "Nolitsin", the instruction calls such types of bacteria (gram-negative) as Salmonella, Escherichia coli, Proteus, Morganella morgani, Shigella, Klebsiella spp, Serratia marcescens, Enterobacter, Haemophilus influenzae, Providencia, Yersiniaseocolomaicaica, Yersiniaseomocolosaica, . In addition, gram-positive bacteria Staphylococcus spp and microorganisms are derivatives of beta-lactamases. Streptococci and anaerobic bacteria are resistant to the drug "Nolitsin", the instruction indicates a low degree of activity against Enterococcus, Acinetobacter.
The course of treatment is usually up to 2 weeks, if necessary, it is extended for a longer period.
The drug is absorbed quickly, but not completely, only up to 40%, after a maximum of a couple of hours the highest concentration is reached, as a result, up to 67% of the active substance penetrates the body tissues. In the gallbladder, liver, bile ducts, prostate and kidneys, the concentration of "Nolicin" is greater than in plasma.
The drug is excreted after a maximum of 6.5 hours, up to 80% through the kidneys in their original form, and the remainder is also excreted through the intestines. Antimicrobial action lasts about 12 hours.
Not all patients can use the Nolitsin medicine; contraindications apply to pregnant women if the patient is under 18 years of age, nursing women, patients with hypersensitivity to norfloxacin.
Patients with epilepsy should take "Nolitsin" with great caution, the instruction also warns about special indications for patients with renal failure, with seizures. Patients need to be given plenty of fluids; blood coagulation should be monitored during surgical interventions. This is due to an increase in the prothrombin index.
The sun should not be abused during treatment with "Nolitsin", if pain appears in the tendons, if the symptom of tenosynovitis occurs, the drug should be discontinued. You should also not resort to strong physical exertion, both during treatment and immediately after it. If the course of treatment is carried out together with Cyclosporin and Theophylline, constant monitoring of their plasma content is necessary.
As for such drugs as iron preparations, sucralfate, zinc and antacid preparations, they should be taken only 2 hours after Nolitsin. Dairy products and yogurt contribute to a decrease in drug adsorption, so they should be taken a few hours before or after taking the drug.
It should not be prescribed to children, adolescents, because medicine has not fully studied its effect on the young body and its negative effect on articular cartilage is not ruled out.
An overdose of "Nolitsin" is sometimes possible, the symptoms are the following: vomiting, nausea, diarrhea, in more severe cases dizziness, convulsions and confusion are possible. Treatment includes symptomatic therapy, gastric lavage, and adequate drinking.