In the article, we will consider why Papaverine hydrochloride candles help.
The drug is a drug that effectively fights against spasms of the smooth muscles of the peritoneal organs, bronchi, brain vessels, kidneys and peripheral vessels.
In addition, this drug alleviates the symptoms of angina pectoris, reduces the excitability of the heart muscle, has a sedative and hypotensive effect, and slows down conduction inside the heart.
The wide distribution of the drug is due to the significant effectiveness of its use, as well as a high degree of safety for the human body. Due to the second property, the drug is often prescribed to pregnant patients to eliminate spasms of the internal organs.
The drug is produced in different forms, in various combinations it is part of combined medicines. These are capsules, injection solutions, tablets and suppositories.
Each form of release has its own advantages, which allow a certain degree of influence on the patient's body. "Papaverine" in candles is often used to relieve spasms and suppress pain, especially in the area of the pelvic organs. However, a drug in the form of suppositories is also no less effective for eliminating spasms of the gastrointestinal tract, pancreatic ducts, and bile ducts. "Papaverine hydrochloride" also helps with a number of other diseases, it is also used for hemorrhoids.
Release forms and composition
The medicine "Papaverine hydrochloride" is available in three forms:
- Injection solution, representing a liquid transparent substance, ampoules of 2.5 and ten milliliters.
- Tablets for oral administration (40 mg) in packs.
- Rectal suppositories are suppositories of a grayish, yellowish or white color, having a specific torpedo shape; In one package there are ten candles, each 0.02 grams. Why do we need candles "Papaverine hydrochloride", many are interested.
All forms of release of this drug have the same active ingredient - papaverine hydrochloride. The only difference is only in the auxiliary substances that are present in the composition of the drug.
The tablets further include starch, sucrose and calcium stearate.
Injection solutions - methionine, edetate disodium and purified water.
Rectal suppositories - solid fat.
The effect of the drug on the body
The main goal, for which Papaverine hydrochloride suppositories are prescribed, is the elimination of smooth muscle spasms and vasodilation. The medicine has a calming effect, allows you to quickly reduce a sharp increase in blood pressure. In addition, it activates the blood rush to the affected organ, helps restore normal heart rhythm.
Doctors note the positive effect of the drug on the smooth muscles of many organs of the respiratory, reproductive and urinary systems, intestines and stomach. Papaverine hydrochloride, which is an active ingredient, additionally eliminates pain, stops seizures. A drug produced in the form of candles is very convenient to use.
Rectal administration of suppositories “Papaverine hydrochloride” allows the active ingredient to be absorbed into the blood, due to which it is delivered to the affected area with high speed. This is what determines the high efficiency of the drug, almost instant improvement in the patient's condition.
The action of the candles "Papaverine hydrochloride" lasts from three and a half to four hours. Then the active component is destroyed and leaves the body with urine.
Indications for the use of candles
Suppositories are prescribed for cramping and / or pain in any organs listed below:
- uterus and appendages;
- pancreas;
- kidneys and liver;
- lungs and bronchi;
- blood vessels of the brain of the head;
- gall bladder;
- intestines and stomach;
- pelvic organs;
- peripheral vessels.
It is advisable to use suppositories for severe pain due to hemorrhoids. In addition, the medicine has been successfully used in preparing a person for surgical interventions.
Candles "Papaverine hydrochloride" are often used in their practice by gynecologists and urologists. The medicine is one of the type 5 phosphodiesterase inhibitors, or PDE-5, it perfectly blocks the action of this enzyme, and therefore can be successfully used to treat male erectile dysfunction or in disorders of the female reproductive system.
Not everyone knows where to insert Papaverine Hydrochloride suppositories during pregnancy.
Rectal suppositories are prescribed during this period, and suppositories are inserted into the rectum. The active component is not dangerous for the expectant mother, and therefore the drug is most suitable for eliminating pain or cramping associated with changes in her body.
The use of suppositories can be an integral part of complex therapy. The drug relieves pain sensations caused by diseases such as bronchitis, pneumonia, various infections (both bacterial and viral), asthma.
Contraindications
Despite the fact that the use of Papaverine suppositories in most cases is absolutely safe for the patient’s body, there are a number of contraindications to their use:
- individual sensitivity or allergic reactions to the active ingredient itself or to excipients of suppositories;
- glaucoma - intraocular pressure rises; due to the fact that the candles dilate blood vessels, a significant increase in the negative symptoms of pathology can be observed;
- the presence of various cardiac conduction disorders; with such diseases, the drug can not be used, since it triggers the activity of the circulatory system;
- renal failure.
Candles "Papaverine" are not assigned to children under six months of age. In addition, the drug is not recommended for elderly patients, as there are age-related changes in their body. When determining pathology of the thyroid gland, as well as endocrinological disorders associated with a deficiency in the production of hormones by the adrenal glands, in case of traumatic brain injuries, rectal suppositories “Papaverine” should be prescribed especially carefully so as not to harm the patient's body.
Feasible side effects
The practice of application shows that suppositories "Papaverine" for the elimination of smooth muscle spasms in the vast majority of cases are tolerated by patients without significant problems. However, the medicine may cause several not the most pleasant unwanted effects:
- lowering the pressure, the use of suppositories for the treatment of patients with normal blood pressure should be dosed correctly;
- enhanced allergic reactions;
- lethargy, fatigue, drowsiness;
- the appearance of concentration disorders: this effect is most often associated with improper production of hormones, the signs of which are intensified after the use of suppositories;
- interruption of the heart rhythm, which occurs most often in the presence of cardiac pathologies;
- vomiting and nausea caused by an overdose of the drug;
- constipation, the occurrence of defecation disorders, the cause of their occurrence is the deterioration of intestinal motility during the elimination of spasms;
- excessive sweating, which is a consequence of lowering blood pressure, in the presence of such a sign, it is necessary to reduce the dosage of suppositories.
Other drug interactions
With the simultaneous use of papaverine hydrochloride with the drug "Methyldopa", the hypotensive effect of the latter may decrease.
The effectiveness of the drug "Levopoda" under the influence of "Papaverine" is reduced.
Consequent use with Alprostadil for the purpose of intracavernous administration may cause priapism.
With the combined use of this drug with anticholinergic drugs, their main properties can increase.
This confirms the instructions for use for the candles "Papaverine hydrochloride".
Overdose
If a too large dosage of the drug was administered, this can lead to intoxication. The main signs of this condition are general weakness, drowsiness, and obvious hypotension.
In addition, diplopia can occur, that is, a visual impairment, which consists in bifurcating objects when a person looks at them.
If one or more symptoms of intoxication appear, you need to stop using the drug in the future, after which:
- rinse the stomach thoroughly using a mixture of activated charcoal and milk;
- carry out supportive and symptomatic treatment to increase blood pressure and eliminate disorders.
In order to eliminate priapism, injections of adrenaline and phenylephrine should be administered in an intracavernous manner.
So, how to use the papaverine hydrochloride suppository during pregnancy?
The use of the drug during pregnancy
It has already been mentioned above that the use of Papaverine suppositories for pregnant women is completely safe. However, despite this, it is better to use them when it is already impossible to do without treatment.
The use of suppositories "Papaverine" is desirable to reduce uterine hypertonicity. This condition manifests itself as constant muscle contractions, which are ultimately ways to terminate a pregnancy. The medicine helps minimize risks. In addition, its calming effect allows the woman to be balanced, eliminates stresses that are dangerous for the future baby.
Statistics reflect that the use of rectal suppositories "Papaverine hydrochloride" during pregnancy only in exceptional cases can harm the body of the expectant mother. Often there are side effects such as increased toxicosis in the first or second trimesters or short-term defecation disorders. But you can easily cope with them if you adjust your diet.
To reduce the harmful effects on the body, a specialist must correctly calculate the dosage of the drug. If under normal conditions suppositories can be used 2-3 times a day, then it is better for a pregnant woman to use them no more than 1-2 times every two days. It must be remembered that self-medication is prohibited in any case. Before using suppositories, you must always consult a gynecologist who will advise the patient regarding the dosage and the appropriateness of taking the drug.
Due to the safe effect on the body, suppositories can be prescribed to a woman at any time during pregnancy.
It all depends only on the features of pregnancy and on what situation has developed in each specific case of the patient.
special instructions
The use of Papaverine hydrochloride suppositories requires caution when controlling multiple mechanisms, driving vehicles, and in activities requiring accelerated reactions, psychomotor skills, and increased attention span.
If you disrupt the therapeutic course and dosage, you can cause heart rhythm disturbances, lowering blood pressure and severe drowsiness.
Instructions for candles "Papaverine hydrochloride" should be strictly observed.
Analogs
If it is impossible to use the original candles, an effective analogue is selected. Among the medicines that can replace the drug, taking into account the influence and purpose, it is necessary to list: “No-Shpa Forte” and “No-Shpa”; Drotaverinum; "Spasmolysin."
Before choosing the best option, it is advisable to consult with a specialist.
Reviews about candles "Papaverine hydrochloride"
Candles due to the minimum number of undesirable effects, affordable cost and high efficiency receive many positive reviews from patients.
If a person has his own experience in using the drug, you must definitely leave feedback on the forums and share your impressions with other Internet users.
Patients who used suppositories noted a strong antispasmodic effect, normalization of blood pressure and a favorable improvement in the state of the nervous system.
According to reviews, the candles "Papaverine hydrochloride" during pregnancy are absolutely safe for women and unborn babies.
Conclusion
Thus, the drug “Papaverine hydrochloride” is produced in three such forms as injection, tablets and suppositories.
Its main purpose is the elimination of spasms of the smooth muscles of the gastrointestinal tract, blood vessels and bronchi. In addition, it is used in the complex treatment of angina pectoris.
It is forbidden to use this drug for children up to one year of age, elderly patients and those who have individual intolerance to the active component and a severe degree of kidney failure.
The use of suppositories "Papaverine hydrochloride" is possible during pregnancy, but you need to do this under the strict supervision of a doctor and not self-medicate.