Many people suffer from hypertension. Moreover, the increase in pressure may not be accompanied by any signs, but appear randomly in the process of measuring it. Although in some cases this condition is still accompanied by a headache, flickering flies in front of the eyes and dizziness.
Lowering high blood pressure should be required. As a rule, special medicines are used for this. One of them is the drug "Vazar N" (160). Instructions for use, reviews, composition and cost of this medication are discussed below.
Form, composition of the drug
In what form is the medicine "Vazar N" produced (160)? Instructions for use informs that this product is made in the form of tablets with a film coating. Their main substances are valsartan, as well as hydrochlorothiazide. In addition, this medicine includes such additional ingredients as lactose monohydrate, croscarmellose sodium, povidone, anhydrous colloidal silicon, microcrystalline cellulose, magnesium stearate and talc.
Pharmacological action
What is the medicine "Vazar N" (160)? Instructions for use, reviews report that this is a combined drug that is intended to treat hypertension.
The main substance of the drug in question is a blocker of angiotensin 2 (its receptors). He is actively involved in the regulation of the function of the heart and blood vessels. It should also be noted that the medication does not block and does not contribute to the binding of ion channels and other hormonal receptors.
As for hydrochlorothiazide, it is a diuretic (i.e. a thiazide diuretic). It is an antihypertensive agent that reduces the reabsorption (renal) of electrolytes, and also increases the excretion of sodium, chlorine, bicarbonate, potassium, water and magnesium. In addition, this tool increases the content of renin in the blood.
The combination of the two substances under consideration is more conducive to a pronounced hypotensive effect than their separate application.
Pharmacokinetic indicators
Where is the absorption of the drug "Vazar N" (160)? Instructions for use states that valsartan is instantly absorbed from the digestive tract. Moreover, the degree of absorption is variable.
The bioavailability (absolute) of this component is 23%, and the connection with plasma proteins is 95-97%. Excretion of valsartan occurs through the intestines and kidneys.
Hydrochlorothiazide is also very rapidly absorbed from the intestines. Its peak concentration is reached after 120 minutes, and bioavailability is 65-85%.
The half-life of the substance in question varies between 6-15 hours (via the kidneys).
Indications for taking oral tablets
In what cases can a drug such as Vazar N (160 / 12.5) be prescribed? Instructions for use reports that this medication is used to treat conditions that are associated with arterial hypertension.
Drug bans
Under what conditions can I not use the drug "Vazar N" (160)? Instructions for use indicate contraindications such as:
- anuria
- hypersensitivity to any of the substances of the drug;
- refractory hypokalemia;
- pathology of liver function of a severe nature;
- cirrhosis and cholestasis;
- hyponatremia;
- pathologies of severe renal function;
- hypercalcemia;
- symptomatic hyperuricemia;
- hypersensitivity to other sulfonamides.
Means of medicine "Vazar N" (160): instructions for use
Analogues of the mentioned drugs will be listed below.
Take "Vazar N" tablets orally with a small amount of liquid, regardless of the meal.
According to the instructions, the daily dosage (initial) of this remedy is 80 mg / 12.5 mg. If the indicated dose was ineffective (for 3-4 weeks), then the treatment is continued in a daily dose of 160 mg / 12.5 mg. Usually, such a dosage of the drug is indicated for people with an insufficient decrease in blood pressure when taking the initial one.
If required, then in the future the specified amount of the drug can be increased to 320 mg / 12.5 mg per day.
The stable effect of taking the drug in question is achieved after 2-4 weeks.
Side effects (after taking the pill)
What adverse reactions does the medicine “Vazar N” cause (160)? Instructions for use states that taking valsartan can provoke:
- orthostatic hypotension, neuralgia, back pain;
- diseases (infectious) of the respiratory tract, including sinusitis and pharyngitis;
- diarrhea, nosebleeds, hypotension;
- conjunctivitis, weakness, arthritis, cough;
- insomnia, syncope, heart failure;
- depression, abdominal pain, asthenia, bleeding;
- myalgia, rashes, hyperkalemia, itching;
- arthralgia, headaches, gastroenteritis, thrombocytopenia;
- vasculitis, angioedema, rhinitis, impaired renal function.
As for hydrochlorothiazide, this substance sometimes causes:
- jaundice, hyperuricemia, arrhythmias;
- hypokalemia, pancreatitis, orthostatic hypotension;
- pulmonary edema, increased amount of lipids in the blood, pneumonitis.
Cases of overdose
Acceptance of exceeding maximum doses may contribute to the development of severe arterial hypotension. Often, this condition causes shock or heart failure.
With an overdose of hydrochlorothiazide, the patient may develop a feeling of nausea, hypovolemia, drowsiness, electrolytic disorders associated with spasms (muscle) and arrhythmia.
Drug Interactions
The concomitant use of Cimetidine, Glibenclamide, Indomethacin, Furosemide, Atenolol, Digoxin, Hydrochlorothiazide, Warfarin and Amlodipine does not lead to significant interaction with Vazar N.
Long-term treatment with NSAIDs can reduce the diuretic and hypotensive effect of the drug in question, as well as lead to impaired renal function.
When combined with anticholinergic agents, the bioavailability of hydrochlorothiazide is increased.
Special recommendations
Now you know why a drug like Vazar N is prescribed (160). Instructions for use, the price of this medication is presented in this article.
With extreme caution, this drug is recommended for people with liver cirrhosis, myocardial infarction, CHF, bilateral renal artery stenosis, as well as in combination with potassium preparations, potassium-sparing diuretics and ACE inhibitors.
For patients with liver damage (non-cholestatic), the dosage of the drug in question should not exceed 80 mg (valsartan).
Reviews, analogues, price
The cost of the drug in question is about 200-600 rubles (depending on the dosage). The analogues of this drug include: “Teveten Plus”, “Mikardis Plus”, “Lorista N”, “Cardosal Plus”, “Lozap Plus”, “Olimestra N”.
The drug "Vazar N" has established itself as a very effective drug for the treatment of hypertension. According to consumer reviews, this medication very rarely causes side effects, is also convenient to use and easily accessible.