"Azidrop" refers to eye drops used in ophthalmology for the treatment of conjunctivitis. When applied topically, they have an effective antibacterial effect.
Composition and form of release of "Azidrop"
According to the instructions, Azidrop eye drops are produced in the form of an oily, colorless liquid, which has a clear to light yellow color. In 1 gram of the drug contains 15 mg of the main active substance - azithromycin dihydrate and up to 1 g of auxiliary components in the form of medium renal triglycerides.
The drug is available in the form of 0.25 g disposable bottles, consisting of high-pressure polyethylene, which are soldered together in ribbons of 3 or 6 pieces, packed in packs of cardboard.
Pharmacological action of eye drops
According to the instructions, Azidrop eye drops are an antimicrobial drug for local use. Azithromycin is a broad-spectrum antibiotic of the second generation of the macrolide and azalide group. It slows down the process of bacterial protein synthesis by binding to the major 50S subunit of the most important non-membrane organelles of the cell - ribosomes, and also prevents the translation of peptides.
Antibiotic resistance mechanism
Three mechanisms of resistance of various bacteria to the action of macrolides are distinguished: those predetermined by modifying the purpose of the action, modifying the antibiotic, or due to the active release of the antibiotic from the bacterial cell due to the active elimination of Azidrop. This transport system, which is important for streptococci (efflux), is encoded by the mef gene located on the chromosome and leads to limited macrolide resistance. Modification of the target of action controlled by the MLSB phenotype leads to cross-antibiotic resistance.
Treatment of conjunctivitis in adults should be comprehensive.
Cases of cross-antibiotic resistance to azithromycin, erythromycin and other macrolides are known. In other words, the drug is not active against microorganisms that are resistant to the above antibiotics.
Description of eye drops "Azidrop" is presented in detail in the annotation.
Pharmacokinetics
After “Azidrop” in the recommended dose is instilled into the eyes for the treatment of bacterial conjunctivitis, azithromycin will not be detected in the blood of patients.
Indications for use
As indicated in the instructions, Azidrop eye drops are used to treat conjunctivitis, which are caused by drug-sensitive microorganisms:
- bacterial conjunctivitis, in which purulent-mucous discharge is observed in children and adults (from birth to adulthood);
- trachomas that are caused by chlamydia trachomatis (trachomatous conjunctivitis) in children and adults (from birth to adulthood).
Drug dosage regimen
Adults with eye damage should be instilled in the conjunctival sac one drop twice a day (morning and evening, respectively) for three days.
For elderly people and children, the dosage regimen does not require correction.
If the patient has no positive dynamics within three days from the start of the use of the drug, it is recommended to consult a doctor who may prescribe a different treatment regimen. For eye drops "Azidrop" instruction confirms this.
Mode of application
In case of eye damage to adolescents and adults, drops of "Azidrop" must be instilled into the cavity between the back and front of the eyelids twice a day. The course of treatment is three days.
The patient must comply with the following recommendations:
- before drip administration of "Azidrop" and after the process, you must carefully wash your hands;
- Do not touch the tip of the bottle directly to the eye or eyelid;
- if after using the disposable vial of "Azidrop" there is still liquid in it, then it must still be discarded, because in no case can the reused solution be used again.
Side effects after the use of "Azidrop"
From the side of the system of protecting the body from diseases during clinical trials, individual hypersensitivity to the components of the drug was rarely observed (no more than one case per 1000 people or less than one per 100 people).
On the part of the visual organs, quite often (no more than one out of 10 cases) after instillation of eye drops from the conjunctivitis "Azidrop" there was discomfort in the system of the visual organs (for example, burning, itching or slight tingling); often (no more than one case out of 100) there was an effect of blurred vision, a feeling of “stuck together eyelids”, a feeling of a foreign body in the eye; infrequently (no more than one case per 1000 or less than one per 100 cases) - lacrimation, conjunctival hyperemia, erythema of the eyelids.
Side effects observed in post-registration clinical trials
The following data on adverse reactions when taking "Azidrop" are based on clinical studies conducted after registration of the drug. The frequency of adverse reactions is determined depending on the Z / X indicator, where X is the total number of samples summarized for all clinical trials conducted. With a proportion of 3/879, the incidence of side effects is classified as infrequent.
On the part of the body's system of protection against diseases, infrequently (no more than one case per 1000 and less than one per 100), Quincke edema (angioedema) was observed.
From the side of the visual organs infrequently (no more than one case per 1000 and less than one per 100) keratitis, conjunctivitis, sometimes allergic conjunctivitis, eczema of the eyelids, eye allergy, swelling of the eyelids were noted. How to apply Azidrop eye drops to a child?
In children, the safety profile of the drug coincides with the adult population, no undesirable adverse reactions have been identified. The side effect profile is also identical for different pediatric groups.
Conjunctivitis treatment in adults and children should be carried out under the supervision of a physician.
Contraindications
"Azidrop" is contraindicated for those who have:
- hypersensitivity to azithromycin and other components that make up the drug;
- hypersensitivity to other macrolide antibiotics.
Use during pregnancy, during lactation
Since the frequency of adverse reactions and systemic exposure from azithromycin are very small, it is expected that the drug will not have a negative effect on pregnant women. That is, you can use Azidrop eye drops for pregnant women.
There is evidence that azithromycin, as a rule, is excreted along with breast milk of a nursing woman, but, given the low dose and low bioavailability, the amount that passes into the baby’s body is extremely small. Therefore, the drug "Azidrop" can be used during lactation.
Clinical studies in animals have confirmed the absence in women and men of the effect of azithromycin on the ability to reproduce healthy offspring. In humans, studies of this nature have not been conducted. But most likely, the drug should not affect fertility.
The use of "Azidrop" in children
Eye drops "Azidrop" are contraindicated for use in children under the age of 1 year.
special instructions
The drug is not recommended to be swallowed or administered in the form of injections, or parabulbar and intraocular injections.
In case of an allergic reaction after the administration of Azidrop eye drops, treatment with this drug should be discontinued.
If the patient is additionally treated with any other ophthalmic means, then Azidrop must be used as the last in line 15 minutes after the previous drug is administered.
The patient must be informed that it is not recommended to administer eye drops at the end of a three-day therapeutic course, even if some residual effects of bacterial conjunctivitis persist.
Dulling of symptoms usually occurs within three days. If there are no signs of improvement after three days of treatment, then perhaps the diagnosis should be reviewed.
Those patients who suffer from bacterial conjunctivitis should not wear contact lenses.
Several times with systemic use of azithromycin, cases of fulminant hepatitis have been reported, which subsequently can lead to life-threatening liver failure. But if the drug is used in ophthalmology, then there can be no such risk, because the systemic effect of the main component is extremely small.
Use in the treatment of children. Comparative clinical studies of the efficacy and safety of using Azidrop for bacterial conjunctivitis have not been conducted in children under the age of 1 year.
In accordance with existing international recommendations for the treatment of diseases of the genitourinary tract and eyes that are transmitted with high probability by newborns caused by Chlamydia trachomatis, a systemic therapeutic course is required.
Impact on the ability to control mechanisms and driving motor vehicles . The influence of Azidrop on the ability to control mechanisms and drive motor vehicles has not been studied.
But it is known that after the introduction of eye drops, blurred vision may be noted. Patients who experience this phenomenon are strongly advised not to work with machinery or drive a motor vehicle until their vision is fully restored. The dosage of Azidrop eye drops should be observed.
Overdose
The dose of azithromycin contained in the package "Azidrop" is enough to cure both eyes. But it is not enough for undesirable effects to occur in case of accidental administration of a solution by the intravenous route or by ingestion.
Interaction with other medicines
Special clinical studies on the interaction of eye drops with other drugs have not been conducted.
Duration and storage conditions
The drug must be stored in a dark place and out of the reach of children at a temperature in the range from 2 to 8 ° C. The shelf life of the drug is three years.
What is the price of Azidrop? Now you will know about it.
Cost
The price of drops of "Azidrop" can vary from 100 to 200 rubles. It all depends on the region of your residence and the pharmacy chain.
Azidrop: customer reviews
Reviews about the tool are only good. After all, it is an effective drug for the treatment of conjunctivitis. In addition to eliminating unpleasant symptoms, he stops the cause of the pathological process. Eye drops can be used by both adults and children. And while observing the dosage and treatment regimen, side effects are minimized.
Azidrop - analogues
The analogues of the product we are considering are: Azibiot, Azivok, Azivon, Azitroks, Azithromycin, Zetamax Retard, ZI-Factor, Zitrocin, Suitrox, Sumazid.