Recently, in almost all countries there has been an increase in the number of gastrointestinal diseases. One of the common pathologies is functional dyspepsia syndrome , or digestive disorders. Such a problem has an extremely negative effect on the quality of life. Such a pathology is most often diagnosed in young people. To get rid of such negative symptoms, doctors prescribe the drug "Domrid". The instruction of the drug indicates that this tool effectively eliminates the negative manifestations of gastrointestinal diseases. Let us consider in more detail at what ailments it is advisable to take the drug, in what dosages, to whom this medicine is contraindicated.
a brief description of
The drug "Domrid" is positioned as a propulsant, or peristalsis stimulator. Among the people, the medicine is better known as an excellent antiemetic. The active substance of the drug is a dopamine antagonist. It has the antiemetic property of peripheral and central action.
Medication "Domrid" instruction states that the medication provides several functions in the human body:
- increases the duration of antrum and duodenal contractions;
- improves the movement of food along the digestive tract;
- stimulates the withdrawal of solid, semi-solid, liquid fractions from the stomach;
- improves pituitary gland production of prolactin.
In this case, the active substance of the drug practically does not penetrate the blood-brain barrier . The use of the drug does not affect the secretory activity of the glands of the digestive tract.
After taking the medicine, it quickly enters the systemic circulation. The highest concentration of the drug is found in the blood 30-60 minutes after administration.
Release Forms
For the convenience of patients, a medicine is produced in several types:
- tablets;
- suspension;
- sustained release tablets.
Indications for use
The drug "Domrid" is intended for the treatment of patients who have a complex of dyspeptic symptoms.
It can manifest itself:
- delayed emptying of the stomach;
- esophagitis;
- heartburn, in which food is thrown into the esophagus;
- a feeling of fullness in the stomach;
- pain in the epigastric zone;
- gastrointestinal reflux without heartburn;
- vomiting, nausea;
- flatulence.
The drug can be prescribed to patients with some other pathologies. If a person has nausea, vomiting of an unknown nature, then the doctor will recommend this remedy. The drug "Domrid" is excellent in fighting against unpleasant symptoms in case of poisoning. Often, such tablets are advised to be taken by people in whom nausea is provoked by chemo- or radiation therapy.
In addition, the medicine perfectly eliminates the negative symptoms provoked by some medications. So, for example, Domrid tablets are able to cope with nausea, vomiting caused by taking Levodopa, Bromkriptin.
The medicine also helps children quite effectively. For children, a special form of the drug "Domrid" is intended - suspension. The instruction recommends using a medication to reduce the severity of such negative symptoms as vomiting, nausea.
Tablet dosage
The drug "Domrid" should be taken as prescribed by the attending doctor. He will describe in detail the pattern of use of this tool.
According to the instructions, Domrid tablets are taken according to the following rules:
- The medicine is intended for oral use.
- To achieve maximum effect, it is recommended to take pills 15-20 minutes before meals.
- Do not grind or chew the tablet.
- The duration of therapy depends on the clinical picture of the pathology and is determined by the doctor.
- In chronic dyspepsia, adults are prescribed 10 mg 3 times a day.
- If necessary, it is allowed to take a fourth dose (10 mg) before bedtime.
- If the patient is diagnosed with a severe form of the disease, then the above dose is doubled.
- With nausea, vomiting, the patient is prescribed to take the medicine three times a day, 20 mg each. An additional dose (overnight) is also allowed if necessary.
- The daily maximum allowable norm of the medication is 2.4 mg / kg. However, it should not exceed 80 mg.
The use of tablets "Domrid SR"
This is a long-acting drug. The doctor also prescribes the treatment regimen with this tool.
The instruction provides the following recommendations for taking such tablets:
- In acute conditions (nausea, vomiting) or dyspepsia, adult patients should take 1 pill once a day.
- Take the medication approximately 15-30 minutes before eating. The pill should not be crushed.
- If necessary, you can additionally take 1 tablet at night.
- For acute conditions, the duration of therapy is 2 days.
- In chronic pathologies (dyspepsia), the course of treatment lasts about 2 weeks.
- The daily maximum dose should not be more than 60 mg.
Suspension use
It is allowed to use Domrid medicine for children. For them, as mentioned above, a special form of this drug is produced - a suspension. However, parents should understand that the medicine cannot be used alone. Such a drug must be prescribed to the child by a doctor. And only a doctor can recommend how much to use crumbs medicine "Domrid" -syrup.
The duration of treatment depends entirely on the pathology. She is also determined by a pediatrician.
The medicine "Domrid" (suspension), the instruction recommends using as follows:
- The syrup is taken orally in undiluted state.
- To maximize the effect of treatment, the suspension should be taken 15-30 minutes before a meal.
- The kit contains a measuring spoon. Use it to accurately measure the amount of medicine you need. In the event that there is a need to draw a dose of less than 2.5 ml, it is recommended to use a disposable syringe (only without a needle).
- If the syrup is taken by adults or adolescents whose body weight is more than 33 kg, then it is recommended to drink 10-20 ml of the drug 3 times a day. An extra serving at night may be used. For this category of patients, the maximum dose during the day should not be more than 80 mg.
- For children older than 1 year, the suspension is prescribed based on weight. The ratio is as follows: 0.25-0.5 ml per 1 kg. The medication is taken 3 times a day. An additional dose is also permitted if necessary.
- Infants under 1 year of age are advised to calculate the rate based on a ratio of 0.25 ml per 1 kg. The drug is used three times a day. You can give babies an extra dose at night.
- It should be borne in mind that for children whose weight does not reach 33 kg, the daily allowance, the maximum allowable, is 2.4 ml per 1 kg.
The initial course of treatment should not exceed 28 days.
Adverse reactions
The use of this medication can sometimes provoke quite negative manifestations in a patient.
The medication "Domrid" instruction indicates the following possible reactions:
- The immune system. Such phenomena are extremely rare. Some patients may develop during therapy: anaphylactic reactions, swelling of the face, legs, arms, feet, urticaria, angioedema, allergies.
- Endocrine system. There may be an increase in prolactin in the blood. This effect is not often observed.
- Nervous system. During therapy with this medication, patients often complain of headaches, dry mouth. Significantly less often, patients encounter such unpleasant symptoms as insomnia, dizziness, lethargy, thirst, increased irritability, irritability, extrapyramidal disorders , drowsiness, convulsions.
- Heart and blood vessels. In some cases, the following negative effects can be observed: swelling, increased heart rate, lengthening of the QT interval, impaired heart rate and rhythm, ventricular arrhythmia. Patients often encounter such pathologies.
- Digestive tract. Quite rarely, negative consequences in this system can occur. As a rule, patients complain of gastrointestinal disorders, pain in the abdomen, regurgitation, diarrhea, changes in appetite, constipation, nausea, heartburn, short intestinal cramps.
- The skin . There are cases when patients sometimes have a rash, itching.
- Mammary glands and reproductive system. Unpleasant disorders such as galactorrhea, amenorrhea, gynecomastia can occur. Similar manifestations are observed quite rarely.
- Urinary system. These organs suffer from therapy infrequently. The patient may experience dysuria, frequent urination.
- Musculoskeletal system. Sometimes patients complain of pain in the legs, asthenia.
In addition to the above side effects, in some cases, the occurrence of stomatitis, conjunctivitis was observed.
The main contraindications
The drug has limitations on admission. Therefore, it is initially recommended to consult a doctor. This will eliminate the risk of quite serious consequences of taking Domrid tablets.
The instruction indicates the following conditions in which the medication is contraindicated:
- Impaired absorption of glucose-galactose, lactase deficiency, galactosemia.
- Intestinal obstruction, an active form of gastrointestinal bleeding, intestinal perforation.
- Prolactinoma.
- Impaired functioning of the liver, kidneys.
- The use of drugs "Ketoconazole", "Erythromycin" and other CYP3 A4 inhibitors.
- The use of drugs that help prolong the QT interval. These are the medicines "Fluconazole", "Voriconazole", "Amiodarone", "Telithromycin", "Clarithromycin".
Do not use the tablet form of the medication for children who are not yet 12 years old. Particular attention is required by newborns and premature babies. For such crumbs, the suspension is prescribed with increased caution.
People who suffer from diabetes should be aware that sucrose is present in the syrup.
The drug is not recommended for use by pregnant women, since the potential risk is unknown. But in some cases, such a tool is still assigned to expectant mothers. However, the doctor will definitely weigh all the risks before such a recommendation.
The active substance easily passes into breast milk. Whether it harms the crumb is unknown. Therefore, it is recommended to stop feeding the baby during therapy with this drug.
Drug overdose
When conducting therapy with this drug, it is very important to adhere to the treatment regimen prescribed by a specialist. It is strictly forbidden to independently increase the dose. Excessive drug abuse, and in any dosage form, can cause a number of negative symptoms.
The main signs of an overdose are conditions:
- drowsiness;
- feeling of weakness;
- impaired consciousness;
- disorientation;
- extrapyramidal disorders;
- cramps.
In this condition, the patient needs immediate assistance. No specific antidote has been developed. Therefore, with the symptoms of an overdose, it is recommended to flush the patient's stomach. The patient must drink a sorbent. For example, activated carbon.
Such conditions are often the reason for the hospitalization of the patient. In a hospital, doctors monitor the well-being of the patient. If necessary, various supporting activities are undertaken.
Medicines for the treatment of parkinsonism, anticholinergics can be used to correct extrapyramidal disorders.
Analogues of the drug
Since gastrointestinal pathologies are quite common ailments, pharmacologists have developed a large number of drugs that can fight unpleasant and painful symptoms.
Synonyms of this drug:
- Domperidone.
- Motilak.
- Motilium.
If necessary, the doctor will recommend analogues of the drug Domrid to the patient that have the same effect on the body as the original drug.
These medicines are:
- "Domstal."
- "Motoricum."
- "Dimetkarb."
- "Dimetpramide."
- Dixafen.
Drug cost
This medicine is produced in Ukraine. At home, the drug "Domrid" is a fairly inexpensive means. The price of the drug depends on the dosage form and packaging.
The average cost of medicines is as follows:
- The drug "Domrid", 30 pcs (10 mg) - 171 rubles.
- Tablets "Domrid SR", 30 pcs (30 mg) - 297 rubles.
- Suspension "Domrid", 100 ml (1 mg / ml) - 160 rubles.
Thus, despite the high effectiveness of the drug Domrid, the price of this product is quite acceptable for the general public.
Reviews about the drug
What do doctors and patients think about this medicine? Initially, it should be noted that in 2013 the drug was tested for safety, efficacy and tolerability. This event was attended by 25 people who have been confirmed functional dyspepsia, and 25 patients with a diagnosis of gastroesophageal reflux disease. After 2 weeks of therapy, these people showed significant improvements. Their dyspeptic symptoms have decreased. Indicators of motor-evacuation functioning of the stomach have improved.
Thus, the effectiveness of the drug "Domrid" was fully confirmed. Reviews of patients do not give the opportunity to doubt the beneficial effect of the drug on the body. People who have encountered quite unpleasant symptoms - nausea, vomiting - indicate that the drug can relieve even the most severe attacks.
Parents who use this medicine for children claim that excruciating vomiting and nausea disappeared in just a day. This allowed to stabilize the condition of the child. At the same time, small patients drink this suspension with pleasure. It has a pleasant pink color and a sweet strawberry flavor. However, after taking a bit bitter aftertaste.
But there is another opinion. Some patients find the drug ineffective. They claim that they drank the medicine for several days according to the scheme prescribed by the doctor. When the unpleasant symptoms disappeared, they stopped using it, so as not to “stuff” the body with chemistry. As a result, nausea returned again.
There are also such patients who directly argue that taking this medication only worsened the condition. After taking the medication, vomiting increased. I had to abandon this tool.
Summary
Analyzing such diverse opinions, one thing can be concluded - this tool should be prescribed by a doctor. The medicine should be taken strictly according to the scheme prescribed by the doctor. In addition, individual sensitivity to the medication cannot be ruled out.