"Tobrex" is a medicine that is used to treat blepharitis, conjunctivitis, keratoconjunctivitis, blepharoconjunctivitis, keratitis, iridocyclitis. The drug is also effective for the prevention of postoperative complications in ophthalmology. The main form of release of the drug is an ointment, which is placed in tubes of aluminum. It has a uniform consistency, white color.
The drug "Tobrex." Instructions for use: composition, pharmacokinetics, pharmacodynamics
The composition of the drug includes the following active substance: tobramycin. Auxiliary components include anhydrous chlorobutanol, mineral oil, white petrolatum.
When used locally, the active substance exhibits a slight systemic effect. When used internally, the bioavailability level is low (up to one percent). The drug is excreted in the urine in an almost unchanged form.
Tobramycin is a broad-spectrum antibiotic that is part of the pharmacological group of aminoglycosides. In low concentrations, it exhibits bacterioscopic effects (blocks ribosome subunits, disrupts the synthesis of protein molecules). When using higher concentrations of the drug, a bactericidal effect is observed. The drug leads to the death of a microbial cell through dysfunction of the cytoplasmic membranes. The drug exhibits action against many gram-positive, gram-negative microorganisms.
The drug "Tobrex". Instruction: method of application, dosage
For eye infections, small amounts of ointment should be applied to the conjunctival sacs of the affected eyes two to three times during the day. As the symptoms of inflammation decrease, it is necessary to reduce the dose of the drug until it is completely withdrawn. In case of acute eye infections, ointment should be applied to the conjunctival sacs of the eyes three to four times during the day. The course of therapy is ten days. The drug is safe for children, newborns. After using the drug, it is recommended to squeeze the nasolacrimal canal, cover the eyelids. This significantly reduces absorption into the systemic circulation, which may be accompanied by the appearance of toxic effects.
The drug "Tobrex." Instructions: side effects, contraindications
Among the side effects, itching, swelling of the eyelids, blurred vision, irritation, transient discomfort, conjunctival erythema most often appear.
Contraindications to the use of the drug is hypersensitivity to its components.
The drug "Tobrex". Instruction: drug interactions
Long-term use of the drug can lead to excessive growth of microorganisms, fungi that are immune to its action. With an unsatisfactory clinical result, it is necessary to do crops before and after therapy. An undesirable combination of a drug with antibiotics, systemic aminoglycosides. The use of several ophthalmic preparations should be carried out at intervals of ten minutes. Lastly, ointment is applied.
The drug "Tobrex." Instruction: special instructions
When treating this ointment, one should refuse to wear soft contact lenses. The drug "Tobrex" during pregnancy is prescribed only in case of urgent need (effectiveness for the mother justifies a significant risk to the fetus). During lactation, the drug can be used in small quantities with short courses of therapy. In nasty cases, it is contraindicated. Due to the possibility of visual impairment, it is forbidden to drive dangerous machinery or vehicles after applying the drug.