The medicine "Neo-Penotran" (candles) is used in gynecology. The product includes miconazole nitrate and metronidazole.
The medicine "Neo-Penotran" (suppositories), the instruction recommends for topical treatment of bacterial vaginosis, trichomonas vulvovaginitis, vaginal candidiasis, as well as mixed type vaginal infections.
Suppositories are contraindicated in severe hepatic function disorders, pathologies of the nervous system (peripheral and central), hypersensitivity, hematopoiesis disorders (hematopoiesis). The medication "Neo-Penotran" (candles), the instruction does not allow for the appointment of pregnant women (in the first trimester), girls under fourteen years old, as well as virgins.
Suppositories must be administered deep into the vagina. The introduction is carried out using special fingertips (disposable). The medicine "Neo-Penotran" (candles), the instruction recommends using once a day. The duration of therapy is from seven to fourteen days.
For relapsed or resistant to other drugs vaginitis is recommended to be administered by suppository in the morning and evening. The duration of use is two weeks.
To use the drug "Neo-Penotran" (candles), the instruction during gestation does not prohibit (except for the first trimester). However, the appointment should take into account the ratio of the intended benefits to the pregnant woman and the potential danger to the fetus.
During therapy, lactation must be stopped. Resume breastfeeding is allowed after two or four days after the introduction of the last suppository.
The use of the drug can provoke a number of undesirable reactions. Side effects include irritation in the vagina, itching, burning. Due to the fact that vaginitis is accompanied by inflammatory processes, irritation may intensify after applying the first suppository or on the third day of therapy. As practice shows, these unpleasant symptoms are eliminated after drug withdrawal. With severe irritation, therapy should be discontinued.
When using the Neo-Penotran suppository, abdominal pain, dry mouth or a taste of metal, vomiting, loss of appetite, diarrhea, or constipation are possible.
In some cases, convulsions, peripheral nephropathy (against the background of prolonged use of the drug), psychoemotional disorders, dizziness, motor disorders, headache are likely.
Probable skin rashes, itching.
It should be noted that the Neo-Penotran agent (candles) (reviews of many patients indicate this) is well tolerated. These negative reactions occur extremely rarely. Many women prefer the drug "Neo-Penotran Forte" (candles). The instruction does not indicate any significant differences between the drugs.
Drug interaction
The drug "Neo-Penotran" in interaction with alcohol provokes disulfiram-like reactions.
The active components of suppositories can enhance the effect of indirect anticoagulants.
When using the Phenytoin medication simultaneously with the Neo-Penotran medication, the level of the first in the blood rises, while the content of metronidazole (the active component of vaginal suppositories) decreases.
With simultaneous use with the medicine "Disulfiram", changes in the nervous system (psychotic conditions) may develop.
The drug "Cimetidine" helps to increase the concentration in the blood of metronidazole. This increases the likelihood of side effects of a neurological nature.
Means "Neo-penotran" increases the toxicity of lithium.
When using vaginal suppositories simultaneously with the drugs "Terfenadine" and "Astemizole", the concentration of the latter in the blood increases.
Before using the Neo-Penotran medication, you should familiarize yourself with the annotation and consult a doctor.