The drug "Spironolactone" is a potassium and magnesium-preserving diuretic. The therapeutic effectiveness of the drug is observed on the second to fifth day of administration. The drug is characterized by good absorption (90% absorbed). The drug metabolism occurs in the liver, excretion - through the kidneys and with bile (in small amounts).
Means "Spironolactone." Instructions for use: indications
The medication is prescribed for secondary hyperaldosteronism due to cirrhosis, complicated by edema and ascites, with nephrotic syndrome. The medicine is indicated for essential hypertension (in complex treatment), hypomagnesemia and hypokalemia (as an adjunct for prophylaxis during therapy and when it is impossible to use other medications to adjust potassium level). The drug is prescribed for edematous syndrome, provoked by chronic heart failure. In this case, the tool can be used for monotherapy or in complex treatment. The medication is prescribed for hyperaldosteronism and for a short dose before surgery.
The medicine "Spironolactone." Instructions for use
With essential hypertension, adults are prescribed 50-100 mg once a day. Allowed to increase the dose of the drug to 200 mg. Dosage increase is carried out every fourteen days. To obtain a therapeutic effect, the medication is taken for at least two weeks. In accordance with the state, the reception scheme is corrected. With idiopathic hyperaldosteronism, the dosage is 100-400 mg per day. In case of hypokalemia and hypomagnesemia, the Spironolactone preparation recommends taking 25-100 mg once or several times a day. Do not drink more than 400 mg per day. Against the background of hyperaldosteronism and hypokalemia of a pronounced course, 300 mg is prescribed 2-3 times / day. To alleviate the condition, the dosage is reduced to 25 mg / day. A course of preoperative therapy is carried out, prescribing 400 mg for four days. In the absence of indications for the intervention, supportive treatment at the lowest therapeutically effective dosage is recommended. The reception scheme in this case is set personally. In the treatment of edema provoked by nephrotic syndrome, 100-200 mg are prescribed.
The drug "Spironolactone." Instructions for use: adverse reactions
The medicine can provoke diarrhea, megaloblastosis, intestinal colic, abdominal pain, alkalosis or acidosis, dizziness, bleeding and gastrointestinal ulcers, hyperuricemia. Based on the treatment, an increase in urea, hypercreatinemia, lethargy, drowsiness, and headache can be noted. When taking the medication, thrombocytopenia, gynecomastia (against the background of prolonged therapy) may occur. In men, when taking the medicine “Spironolactone” (reviews confirm this), erectile dysfunction is likely. In women, metrorrhagia during menopause, coarsening of the voice, carcinoma and tenderness in the mammary glands, dysmenorrhea are possible. Allergies, itching, rashes, muscle cramps are referred to the negative consequences - this is indicated by the instructions for use attached to the Spironolactone preparation. The price of the drug is about 100 rubles.