Raising cholesterol causes serious concern, especially if a person suffers from cardiovascular diseases. The drug "Klivas", the instructions for use which describe in detail the rules for taking the medicine, helps to lower cholesterol to normal and stabilize the patient's condition in the future.
Composition and form of release
The drug "Klivas" (instructions for use attached to the medicine) is available in white-coated tablets. The pills are enclosed in an aluminum blister of ten pieces. A cardboard box may contain one or three blisters.
Tablets are available in doses of 10 mg and 20 mg. The active substance is rosuvastatin.
Pharmacology
Rosuvastatin is a selective inhibitor of HMG-CoA reductase, an enzyme. Converts HMG-CoA to mevalonate, a precursor to cholesterol. The main area of work of rosuvastatin is the liver. This is where the union of cholesterol and LDL catabolism occurs.
The therapeutic effect is noticeable during the first week of taking the drug, after 14 days a positive result is 90%. The greatest effect can be achieved by taking the drug continuously for a month.
Reception of rosuvastatin gives the best result both in the treatment of patients with hypercholesterolemia and without hypertriglyceridemia. The effect occurs regardless of gender, age and race. A positive result is observed in people with diabetes and suffering from familial hypercholesterolemia.
Additivity is observed in combination with fenofibrate in the presence of TG and with nicotinic acid in relation to HDL cholesterol.
Indications
The use of the drug "Klivas" (instructions for use report contraindications that should be considered before using the medicine) for adults is indicated for hypercholesterolemia. Assign the drug in the primary stage of hypercholesterolemia and in the mixed type of dyslipidemia. Tablets are used as an additional therapy to the diet, when therapeutic nutrition, physical education and weight loss are not enough.
The drug is prescribed for homozygous familial hypercholesterolemia. They are supplemented by a diet and the use of other lipid-lowering drugs. The drug is prescribed also when the use of the above methods is not possible.
They recommend a medicine for patients with cardiovascular disorders, with the likelihood of atherosclerotic diseases of a cardiovascular nature. These risk factors include high blood pressure, old age, lowered cholesterol, increased C-reactive protein, a predisposition to the development of coronary heart disease, and smoking.
The drug is often used in the treatment of atherosclerosis. In this situation, it slows down the development of the disease in people who are prescribed lipid-lowering therapy.
Klivas can be used to treat children aged ten to seventeen. Boys should have stage II of the disease and higher on the Tenera scale, girls can take the drug no earlier than a year after the start of their first menstruation. Here, the drug is prescribed for the treatment of primary hypercholesterolemia, as well as for the diagnosis of mixed dyslipidemia, if the disease has developed due to heterozygous familial hypercholesterolemia. The drug is used in combination with a therapeutic diet and along with non-drug methods of treatment.
Contraindications
Klivas tablets (the instructions for use before taking the medicine must be studied), despite the high therapeutic effect, you can not use it with hypersensitivity to the active ingredient of the drug - rosuvastatin, as well as to any auxiliary component in their composition. A ban on use are liver disease in their active phase, severe malfunctioning of the kidneys and myopathy. Do not combine medication with cyclosporine. Doctors do not prescribe pills if the woman is pregnant or breastfeeding. Ladies of childbearing age when using the medicine are recommended to use adequate contraceptives.
A dosage of 40 mg should not be prescribed to people with a predisposition to the progression of myopathy / rhabdomyolysis. This includes diseases of the renal system of moderate severity, hypothyroidism, a history of hereditary muscle diseases and myotoxicity, and an addiction to alcoholic beverages. Do not take such a dose in situations that increase the level of active substance in the blood. You can not take this amount of the drug to persons of the Mongoloid race.
Klivas: instructions for use
20 mg (10 mg) of the active ingredient of rosuvastatin is contained in each tablet. Pills are drunk regardless of the time of day or eating food. They can not be chewed, but should be swallowed whole, washed down with plenty of water.
Therapy for hypercholesterolemia begins with small doses, 5-10 mg once a day. This amount is suitable for both individuals who have not previously used statins and patients who have previously used HMG-CoA reductase inhibitors. When calculating the initial dose, they rely on the natural level of cholesterol in the blood and on the possible risk of cardiovascular diseases, the likelihood of side effects. You can increase the dose after four weeks.
Given that with a daily dose of 40 mg, side effects develop more often than with a smaller amount of the drug, only patients with a severe stage of hypercholesterolemia and a high risk of developing cardiovascular diseases should raise the dose to 40 mg. If the desired result is not obtained at a dose of 20 mg, then with an increase in dosage to 40 mg, the patient should be under the supervision of a doctor.
For the prevention of cardiovascular failure, the daily dose is 20 mg. For older people over 70, the daily norm should not exceed 5 mg.
For children and adolescents with heterozygous familial hypercholesterolemia, the drug is prescribed 5-20 mg once a day, the dose should be titrated.
For people with moderate renal impairment, the initial dosage is 5 ml. The drug in an amount of 40 mg is contraindicated. You can not use "Clevance" (the instructions describe this situation in more detail) for patients with severe diseases of the renal system.
Tablets are contraindicated for people suffering from active kidney disease. In patients with severe diseases of the renal system, an increase in rosuvastatin may be observed. In this case, the therapeutic dose does not exceed 10 mg.
In individuals of the Mongoloid race, an increase in the systemic exposure of rosuvastatin was noted, therefore, treatment begins with 5 mg. A therapeutic dose of 40 mg is strictly contraindicated. The maximum daily allowance is 20 mg.
People prone to the progression of myopathy begin therapy with 5 mg, and a dose of 40 mg is prohibited for many of them. The maximum amount of substance taken per day is 20 mg.
Side effects
Many patients are interested in: Does the negative reaction of the body cause Klivas (tablets)? The instruction describes in detail all the features of the use of the drug. According to the annotation, only mild and transient side effects were recorded. Nausea, dizziness, myalgia, constipation, diarrhea, asthenia (at high doses), cough, myopathy were observed.
From time to time, patients developed itching, hives, rashes on the skin. Cases of proteinuria with tubular origin have been reported. There was a change in protein in the urine, which was expressed in an increase in hepatic transaminases. Mild depression, insomnia, nightmares and sleep disturbances, sexual dysfunction have been recorded.
During treatment, people were worried about the reactions, which were caused by a special sensitivity to the drug (sometimes there was angioedema). Some patients have been diagnosed with pancreatitis and myopathy (including myositis). Rhabdomyolysis was recorded, its frequency in some cases depended on the dose increase.
Very rarely polyneuropathy, memory loss. In isolated cases, jaundice and hepatitis were recorded. Sometimes there was Stevens-Johnson syndrome, arthralgia, hematuria, swelling.
Overdose
We strongly recommend that you follow the recommended dosage when taking the Klivas pills instructions. Reviews claim that this is an effective and very affordable drug. It gives a lasting lasting result. An individual dose is calculated for each patient, and if it is not observed, an overdose may occur. Special treatment is not provided here. Therapy is carried out according to the symptoms that arise. At this time, you need to carefully monitor the liver and the level of CPK. Hemodialysis does not give the desired effect.
Storage conditions
Klivas medicine (the instructions for treatment with this drug must be followed) should be stored in its original packaging at a temperature regime not exceeding +25 ° C, out of the reach of children. The medicine is valid for two years from the date of manufacture.
Analogs of Klivas
The drug "Klivas" is not common in Russia, therefore, despite its effectiveness, people have to look for a replacement.
The following medicines are referred to analogues having the same active substance (rosuvastatin) with their composition: “Krestor”, “Mertenil”, “Redistatin”, “Rovix”, “Rosav”, “Rosart”, “Rosvator”, “Rosuvastatin Krka” ”,“ Rosuvastatin Teva ”,“ Rosucard ”,“ Rosulip ”,“ Rosusta ”,“ Romestin ”,“ Rosukor ”,“ Rofast ”,“ Fastrong ”.
These and other drugs are able to completely replace Klivas. The difference between them is the price, manufacturer and concentration of the active substance.
Patient Reviews
Warns that it is important to follow all the doctor’s instructions when taking the Klivas tablets, instructions for use. Reviews about this drug are extremely positive. Patients say that over the first two weeks, the drug stabilizes the patient's condition and normalizes cholesterol. It is cheap and patients taking it are satisfied with the result.
Warns that it is important to follow all the doctor’s prescriptions when taking Klivas tablets, instructions for use. Reviews about this drug are extremely positive. Patients say that over the first two weeks, the drug stabilizes the patient's condition and normalizes cholesterol. The drug is cheap, and patients taking it are satisfied with the result.
Despite this, some people who took large doses indicated side effects. They had disturbed sleep, nightmares, and depression. However, doctors recommended that you do not stop treatment and drink the medicine for at least a month. After a course of administration, cholesterol returned to normal in patients, and side effects disappeared.