The drug "Sulfasalazine EN" is an anti-inflammatory, anti-rheumatic, immunosuppressive, bacteriostatic intestinal agent. The mechanism of action of the drug is based on the properties of the active components.
The active substance salazosulfapyridine is an antibiotic from the sulfonamide group. The component has bacteriostatic activity against gonococci, streptococci, diplococci, Escherichia coli.
The active component 5-aminosalicylic acid has an anti-inflammatory property, it inhibits the synthesis of prostaglandins and suppresses cyclooxygenase.
Means "Sulfasalazine" (instructions for use contains such information) blocks the transformation in lymphocytes and inhibits monocytes. The drug affects both cellular and humoral immunity.
The drug is poorly absorbed from the digestive tract.
The drug "Sulfasalazine" recommends the use of the drug for ulcerative proctitis, nonspecific colitis (ulcerative). With these pathologies, the medication is used in the treatment of exacerbations and as maintenance therapy in remission.
The tool "Sulfasalazine" recommends the use of the drug for Crohn's disease (with moderate and mild forms in the acute phase).
The drug is also prescribed for rheumatoid arthritis (including juvenile).
The medicine "Sulfasalazine" recommends taking it after use. The dosage should be set individually in accordance with the severity of symptoms, as well as possible side effects.
Usually, adults are prescribed from 500 to 2000 milligrams four times a day until the manifestations of pathology are relieved. Subsequently, the patient is transferred to maintenance treatment. The dosage in this case is 500 milligrams three to four times a day. The duration of therapy is several months.
Dosage for children: from five to seven years - 250-500 milligrams from three to six times a day, from seven years - 0.5 grams three to six times a day.
For adults, the therapeutic dosage is 1.5-3 grams. As practice shows, the effect occurs after six or ten weeks. Therapy is continued for at least six months.
The drug is contraindicated in case of anemia, porphyria, severe disorders in the activity of the liver or kidneys, hypersensitivity (including salicylates, sulfonamides). Do not prescribe the drug "Sulfasalazine" for children under five years of age. Contraindication is the period of lactation. If you need to use the medication while breastfeeding, you should decide on the termination of lactation.
During pregnancy, the medicine can be prescribed strictly according to the indications in the minimum therapeutic dosage under medical supervision. It is not recommended to take the drug "Sulfasalazine" in the third trimester of pregnancy.
Most of the side effects of the medication depend on the dosage taken and is the result of the activity of salazosulfapyridine (active substance).
The medicine can provoke peripheral nephropathy, dizziness, interstitial nephritis, sleep disorders, tinnitus. During treatment, disorders in the activity of the kidneys, diarrhea, thrombocytopenia, lesions in the lung tissue, leukopenia, infertility and oligospermia (transient) may be noted. Adverse reactions also include vomiting, pancreatitis, agranulocytosis, anaphylactic shock, anemia, urticaria. In rare cases, disorders in the functions of the nervous peripheral system, skin reactions can be noted.
During the use of the drug, it is recommended to use a large amount of liquid.
There is no data on whether the drug "Sulfasalazine" has analogues for the active substance.
Before using the medicine, experts recommend that you read the annotation.