"Indap": instructions for use, analogues, reviews

The drug Indap belongs to the group of diuretics and is recommended for patients to eliminate a persistent increase in blood pressure.

The medication is in the form of capsules for oral administration. Inside there is a powder of a milky shade, which easily breaks up when pressed. Capsules are packaged in ten pieces in blisters.

Structure

According to the instructions for use with Indapu, the main component of the drug is indapamide, one tablet contains two and a half milligrams of the active substance. Additional trace elements are:

• cellulose;
• silica;
• titanium oxide;
• dye;
• starch.

Properties, indications

The drug is recommended for people to regulate blood pressure. Indap belongs to the group of thiazide-like diuretics. Under the influence of the active substance, the tone of the smooth muscles of the blood vessels decreases, a weak diuretic effect is observed.

The antihypertensive effect of Indapa can be observed by the end of the first week from the start of treatment and reaches its maximum after about two to three months.

After taking the medicine, the pharmacological effect persists for another twenty-four hours, which makes it possible to take the drug only once a day.

According to the instructions for use, Indap tablets are prescribed to patients for the treatment of hypertension.

Contraindications

The drug should be used only on the recommendation of the attending physician.

Before treatment, it is important for the patient to thoroughly familiarize themselves with the instructions for use of Indap, and at what pressure the medicine is used, you also need to know, since the tablets have a number of prohibitions on use:

1. Hypokalemia (low plasma potassium).
2. Acute disorders of blood microcirculation.
3. Lactation.
4. Severe lesions in the functioning of the liver and kidneys.
5. Lactase deficiency.
6. Pregnancy.
7. Age to eighteen.

With extreme caution and strictly under the supervision of a doctor, this medicine is taken for the following diseases:

1. Violation of the metabolism of carbohydrates and water in the body.
2. Gout (metabolic disease, which is characterized by the deposition in various tissues of the body of crystals of urates in the form of sodium monourate or uric acid).
3. Changes in the normal acidity of body fluids and the accumulation of salts.
4. Coronary circulation disorder.
5. The accumulation of free fluid in the abdominal cavity.
6. Violation of the functioning of the endocrine system.
7. Heart disease.

Instructions for use

Indap capsules are recommended for patients to use once a day, preferably immediately after a meal. The capsule should be swallowed whole, washed down with water.

Indap can be used both as an independent pharmacological agent and as part of combination therapy with other medicines from the group of antihypertensive drugs.

If thirty days after the start of the course, the result is invisible, then the dosage of the medicine is not increased, and under the supervision of a doctor, another drug from the group of antihypertensive drugs that does not have a diuretic is prescribed.

If you start treatment with two drugs at once, the amount of active substance will remain unchanged: per day - 2.5 mg. Indap, the instructions for use of which is presented in the article, is usually well tolerated by patients.

Can I take Indap during pregnancy?

The drug is prohibited for use by pregnant women, since there is no information on the safety of the main trace element for the development of the unborn child.

Indap is contraindicated for the treatment of women during lactation. If therapy is necessary, it is recommended to stop breastfeeding.

Side effects

During treatment, patients may develop negative reactions.

From the digestive system:

• nausea;
• belching;
• vomiting
• loss of appetite;
• increased dry mouth.

From the nervous system, the following deviations may occur:

• drowsiness;
• lethargy;
• migraine;
• anxiety;
• irritability.

From the side of the visual organs, the following ailments develop:

• inflammation of the mucous membrane of the eye;
• visual organ dysfunctions.

The respiratory system can manifest some negative reactions, for example:

• a condition in which an increased amount of mucus forms in the nose;
• inflammation of the mucous membrane of one or more sinuses;
• pharyngitis.

From the side of the cardiovascular system, the following reactions may occur:

• arrhythmia;
• hypokalemia;
• orthostatic hypotension;
• cardiopalmus.

In addition to these negative manifestations, a number of deviations may occur, for example:

1. Night diuresis.
2. Increased urine output per day.
3. The development of urological infections.
4. Rash.
5. Itching
6. Redness.
7. Nettle fever.
8. The development of hemorrhagic vasculitis.
9. Leukocytosis.
10. Agranulocytosis (a pathological condition in which there is a decrease in the level of leukocytes and granulocytes).
11. Hemolytic anemia (erythrocyte pathology, the hallmark of which is the accelerated destruction of red blood cells).
12. Increased levels of calcium in the blood, chlorine and nitrogen.
13. The appearance of glucose in urine.

In rare situations, as a side effect, the patient has flu-like symptoms, problems with potency and sex drive, as well as pancreatitis.

Overdose

When using high dosages of the drug, the patient may experience the following symptoms of poisoning:

1. Nausea.
2. Vomiting.
3. Strong pain in the gastrointestinal tract.
4. The development of acute vascular insufficiency.
5. Suppression of respiratory function.
6. Emotional stress.

The elimination of an overdose consists in washing the stomach, as well as conducting complex treatment.

Interaction

The drug "Indap" should not be used in conjunction with drugs that contain lithium, as this can trigger the development of intoxication of the kidneys.

When taking the medication with "Erythromycin", "Sotalol", "Quinidine", the hypotensive effect is weakened and the electrocardiogram indicators change.

With the simultaneous use of Indapa with drugs from the group of anti-inflammatory drugs or glucocorticosteroids, a decrease in the hypotensive effect is observed.

When using Indapa with laxatives, cardiac glycosides, the likelihood of hypokalemia increases.

The main trace element increases the risk of kidney failure with the combined use of contrast components based on iodine.

Soothing and psychotropic drugs increase the antihypertensive effect of the capsules, which leads to collapse.

The combined use of the drug with cyclosporine can provoke an increase in the level of creatinine in the blood.

special instructions

The drug is highly effective for eliminating arterial hypertension in patients with diabetes mellitus, chronic renal and heart failure, as well as impaired liver function.

Patients from this group with impaired renal function during the Indapom therapy need to periodically donate blood to assess the general condition. Against the background of treatment in such patients, hypercalcemia, hypokalemia and hyponatremia may occur.

Under the influence of the drug in humans, the excretion of magnesium with urine increases, which with prolonged therapy can provoke the development of hypomagnesemia.

During the course, Indap capsules are not recommended to take alcoholic beverages, as this may lead to orthostatic hypotension.

According to the instructions for use with the Indap drug, when hypokalemia occurs while taking this drug in patients with joint use of cardiac glycosides, the likelihood of intoxication increases sharply.

If a person is forced to periodically use cardiac glycosides, then with Indapom therapy it is necessary to constantly monitor the level of potassium and creatinine in the blood.

Seven days after the start of treatment, the patient must first measure the level of potassium in the blood. People with diabetes should monitor their blood glucose levels from time to time during treatment with the drug. In rare situations, insulin needs to be adjusted.

Patients who used diuretic drugs, three days before the start of the course "Indapa" need to cancel diuretics.

Against the background of drug therapy, the clinical picture of systemic lupus erythematosus in humans may worsen.

Since during therapy with the drug, patients may experience dizziness, drowsiness, there is a need to refrain from controlling mechanisms that require increased attention, according to reviews and instructions for use.

Indap: analogues

The following drugs are considered similar in their pharmacological effects to the drug:

1. "Indapamide".
2. "Acripamide".
3. "Ionic".
4. Tenzar.
5. Indapen.
6. Indopres.
7. "Vasopamide".
8. Lorvas.

Before changing a prescribed medication with a substitute, consult a medical professional.

Indapamide

The medication is a diuretic with a pronounced antihypertensive effect, which is prescribed to people to eliminate arterial hypertension, like Indap. According to the instructions for use, 1.5 mg of the active substance is contained in one capsule of Indapamide.

The drug belongs to the group of diuretics with a pronounced hypotensive effect. After taking the medicine, the oral pharmacological effect persists for twenty-four hours. The result can be observed seven days after the start of treatment, and it reaches its maximum by the end of the second month of therapy.

Under the influence of the active substance, hypertrophy of the left ventricle of the heart decreases, the elasticity of the walls of the arteries increases. The cost of the medicine is from 40 to 500 rubles.

Indapen

The drug is produced in the form of tablets for oral administration. The active ingredient is indapamide. It is a thiazide-like diuretic drug with antihypertensive effect. Indapen is an analog of Indapa.

According to the instructions for use, the mechanism of action is due to the elimination of contractility of the smooth muscles of blood vessels by reducing intracellular calcium transport and stimulating the synthesis of prostaglandin, which has a vasodilating effect. The drug lowers blood pressure gradually.

The hypotensive effect of the main substance is more pronounced than the diuretic. After use, the active substance is instantly and completely absorbed in the gastrointestinal tract. The maximum concentration in the blood is reached two hours after administration.

Food does not affect the absorption rate of the drug. Indapamide comes into contact with plasma proteins at seventy-nine percent. Seventy percent of the dosage taken is excreted in urine as metabolic products, and only seven percent in unchanged form. And thirty percent of the medication taken is excreted in feces.

Storage conditions

"Indap" is released from the pharmacy strictly according to the doctor’s prescription. It is necessary to store tablets in a place inaccessible for children at a temperature of no more than twenty-five degrees. The shelf life of the drug is three years. The average cost of Indapa in pharmacies is about one hundred rubles.