At what dosage is the Pangrol medication prescribed? Instructions for using this medication will be described in this article. It also provides information about the composition of the drug in question, whether it has contraindications and side effects.
Drug release form and its packaging
In what form is the drug "Pangrol" produced? Instructions for use, reviews of doctors indicate that this product goes on sale in the form of cylindrical solid and opaque gelatin capsules, as well as tablets.
The shell of this medicine has a light orange color, and the capsule lid is a yellow-green hue.
The contents of the capsules are granules of a cylindrical shape. They have a shiny surface and enteric coating, and are also light beige in color.
In what packaging is Pangrol medicine sold? Instructions for use with the medicine (20, 100 or 50 capsules) are enclosed in a polypropylene bottle. The medication in tablet form is packaged in blisters and placed in cardboard boxes.
The composition of the drug
What is a part of the drug "Pangrol" 10000? Instructions for use inform us that the active substance of this medication is pancreatin. Also, the composition of the medicine also includes such additional elements as croscarmellose sodium, magnesium stearate, hydrogenated castor oil, anhydrous colloidal silicon dioxide and microcellulose.
Pangrol preparations of 20,000 and 25,000 have a similar composition.
Pharmacological properties of the drug
What is the Pangrol medicine? Instructions for use (the composition of this drug was described above) states that this medication belongs to the group of digestive and enzymatic agents. After oral administration, it helps to fill the deficit of substances that are essential for the normal functioning of the pancreas.
Also, the drug in question is capable of exerting amylolytic, proteolytic and lipolytic effects.
Pharmacodynamics of the drug
How does the drug "Pangrol" 25000? Instructions for use states that pancreatin, which is part of this drug, is a powder obtained by processing the pig glands (pancreas). The enzymes contained in it favorably affect digestion processes, and also accelerate the breakdown of carbohydrates, fats and proteins. Also, this substance contributes to the normalization of the pancreas itself.
What properties does Pangrol have? The instruction for use suggests that by improving the digestion of food, this medication quite effectively removes such signs of digestive disorders as a feeling of fullness of the stomach, shortness of breath, pain and heaviness in the abdomen, gas congestion, flatulence and so on.
Taking capsules and tablets, the patient stimulates the pancreas, as well as the stomach and small intestine, which subsequently produce all the necessary enzymes involved in the digestive process.
The bile extract included in the preparation acts on the human body choleretically, and also enhances the emulsification of fats. Thus, it increases lipase activity, improving the absorption and digestion of fat-soluble vitamins A, E and K.
Pharmacokinetics of the drug
How does the drug "Pangrol" 20,000? Instructions for use give a lot of information on this subject. The drug "Pangrol" is covered with a special acid-resistant coating that helps protect the drug from the effects of gastric juice until the product enters the small intestine. In this case, the capsule shell dissolves quite quickly, after which it releases granules that contain digestive enzymes. Mixing with the contents of the intestine, they provide it with the necessary level of enzymes.
For a more effective effect, it is very important in the small intestine to maintain a slightly alkaline or neutral pH.
It should also be noted that the drug "Pangrol" is not absorbed from the digestive tract. At the same time, it is excreted from the body only with feces.
Indications for use
The medication under consideration is actively used as replacement therapy in adults and young children with impaired exocrine pancreas.
In addition, the drug "Pangrol" is prescribed for relative enzyme deficiency, which was caused by one of the following diseases:
- pancreatitis (including in chronic and acute stages of the disease);
- pancreatic cancer or narrowing of the duct, which was caused by the presence of a malignant tumor or gallstones;
- intestinal infections;
- Schwachmann-Diamond syndrome;
- disorders of the digestive tract, which are functional in nature;
- irritable bowel syndrome;
- cystic fibrosis.
It cannot be said that the drug in question is actively used to prepare the patient for x-ray or ultrasound of the abdominal cavity, as well as to normalize the function of the stomach and pancreas after surgery (for example, after resection or as part of complex therapy after irradiation in the presence of signs such as flatulence, not digestion of food or diarrhea).
Contraindications
Under what conditions is it not recommended to take the Pangrol medication? Instructions for use (the indications of this medication were listed above) indicate the following prohibitions:
- acute pancreatitis;
- hypersensitivity of the patient to drug substances;
- exacerbation of pancreatitis.
The drug "Pangrol": instructions for use
According to the instructions, this drug should be taken with food. However, it is not recommended to chew (should be swallowed whole).
Tablets and capsules should be washed down with room temperature liquid. The dose of the medicine is determined by the doctor and depends on the condition of the patient, as well as the form and severity of the disease.
When prescribing capsules, the following therapeutic doses must be adhered to:
- adults - 1-2 or 2-4 capsules of the drug "Pangrol" 25,000 or 10,000, respectively;
- small children - calculated as follows: 500-1000 units of medicine per 1 kg of weight at each meal.
As for the tablets, they are taken in 1-2 pieces during each meal. The average therapeutic dose of this medicine may vary depending on the disease, as well as the food that the patient consumes.
If necessary, the doctor can increase the daily dosage. However, it is imperative to adhere to the maximum allowable limits of 15,000-20000 lipase units per kg.
How long should the treatment under consideration be considered? The course of treatment depends on the type, severity of the disease and the state of human health.
If the patient cannot take the whole capsule (for example, elderly people or small children), then its contents can be poured into a liquid or mixed with food that does not need to be chewed (for example, fruit puree). It should be especially noted that a mixture of food and tablets should not be stored. It must be consumed immediately.
For the treatment of cystic fibrosis, the dosage of the drug is also selected by the doctor. As a rule, it depends on the patient’s body weight.
The initial dose of the drug for children under 4 years old should be 1000 units per 1 kg of weight, and for children over 4 years old - 500 units.
When using the medication in pediatrics, it is imperative to follow a diet in order to exclude the development of steatorrhea.
Overdose cases
Diseases such as hyperuricosuria and hyperuricemia can signal an overdose of the Pangrol medication and an increase in the number of enzymes in the treatment of cystic fibrosis. In this case, the drug should be discontinued, and then consult a doctor immediately.
Side effects
During treatment with Pangrol, patients may develop side effects such as diarrhea, bloating, nausea, digestive disorders, vomiting, abdominal pain and others.
It is very rare for people taking this medicine to have an allergic reaction (itching, hives, skin rashes). If such symptoms are detected, stop using the drug and consult a doctor.
Special recommendations
During the treatment of cystic fibrosis, people receiving high doses of the drug may develop fibrosing colonopathy (that is, strictures of the cecum, colon, and ileum can occur). To avoid such pathologies, before taking the medication, you must definitely undergo a medical study in order to exclude the presence of intestinal lesions in the patient.
Analogs and price of the drug
Now you know why Pangrol is prescribed. Instructions for use (analogues of this medication will be listed right now) of the mentioned remedy has been described in detail above.
If you could not purchase this drug in your region, then you can replace it with one of the following analogues (after consulting a doctor): Gastenorm Forte, Hermitage, Creon, Pankrelipaza, Mezim, Enzistal P ”,“ Mikrazim ”,“ Penzital ”,“ Mezim Forte ”,“ PanziKam ”,“ Pancreatin Forte ”,“ Panzinorm ”,“ Festal ”,“ Pancreatin ”,“ Pancitrat ”,“ Panzinorm Forte ”,“ Pancreatin-LekT "," Panzim Forte. "
The cost of the drug in question depends on the form. A package with 50 tablets can be purchased for 1000 rubles, and 20 capsules for 250 rubles.
Reviews about the drug
In most cases, people taking the drug "Pangrol" leave positive reviews. This medication effectively copes with the task. Its only drawback is the difficulty in calculating the dose. Due to the fact that digestive problems are always individual in nature, only an experienced specialist can choose the right dosage. This fact makes it difficult to take the medicine on your own.