Suppositories "Prednisolone" are a high-quality synthetic glucocorticoid hormone, which in its effectiveness is similar to the substance that under normal conditions is produced by the human adrenal glands. The drug has anti-inflammatory, anti-shock, anti-allergic, antiproliferative, immunosuppressive, as well as antipruritic effect. To achieve a positive therapeutic result, you must first familiarize yourself with the instructions, and also choose the right dosage.
Drug description
Candles "Prednisolone" are a more active dehydrogenated analogue of multifunctional hydrocortisone, which can be used systemically or locally. The crystalline powder is odorless, painted white with a slight yellow tint. The final molecular weight of the substance is 360 g / mol. The drug does not dissolve in water.
The drug "Prednisolone" is a hormonal medication. It belongs to the group of glucocorticosteroids. These hormones are necessary for a person to maintain many important processes. This primarily concerns the suppression of viral infections and dangerous pathologies. In addition, glucocorticosteroids have an immunosuppressive effect and eliminate swelling of the bronchi. Many experts prescribe Prednisolone as an anti-shock drug. Due to its high efficiency, the medication is also used for other complex ailments. Among them, one can distinguish bronchial asthma, systemic lupus erythematosus, rheumatoid arthritis, as well as psoriasis.
As the active ingredient, prednisone is used. Excipients from different manufacturers may vary slightly, which is why you can study the composition on the packaging of the drug or in the attached instructions.
Pharmacological properties
The inflammation that occurs in the proliferative phase is effectively neutralized by increased doses of Prednisolone. As a result, the patient's fibroblast activity decreases, the production of reticuloendothelium and collagen is inhibited. The active substance promotes the synthesis of protein in the liver. The drug helps to stabilize the state of cell membranes, reduce the activity of metabolites and xenobiotics of increased toxicity. The treatment allows you to achieve a powerful antitoxic effect.
Candles "Prednisolone" help reduce the rate of development of lymphoid tissue. Maximum involution is achieved by exclusively prolonged use of the medication. Thanks to this, the human bloodstream reacts much better to vasoconstrictors, and besides, receptors become more sensitive to catecholamines. During therapy, water and sodium may linger in the body.
Operating principle
"Prednisolone" is a synthetic hormone that acts on the human organs similarly to those compounds that are produced in the adrenal glands. The medication itself has the following principle of action:
- The inflammatory process is eliminated as quickly and efficiently as possible, regardless of its location and severity.
- Relieves shock and prevents patient death.
- It stops the uncontrolled proliferation of cells at the site of tissue damage, which prevents the formation of scars.
- The development of an allergic reaction stops, and the symptoms characteristic of this condition are eliminated: itching, burning, swelling, rash.
- Suppresses the active release of fluid from inflammatory tissues.
- Normalizes the immune system.
All these effects from the use of Prednisone develop extremely quickly, and the positive effect of the medication itself is quite strong. Thanks to this, therapy can be prescribed even in case of a life threat and in cases where other drugs have been ineffective.
Indications for use
Qualified doctors prescribe Prednisolone suppositories as part of the complex therapy of hemorrhoids to quickly alleviate the symptoms of such a painful disease. High-quality suppositories can qualitatively fight the following pathologies:
- Polymyositis, dermatomyositis.
- Chronic connective tissue diseases.
- Acute adrenal insufficiency.
- Rheumatoid arthritis, rheumatic fever.
- Addison's disease.
- Myocarditis, systemic vasculitis.
- Hepatic coma.
- Bronchial asthma, asthmatic status.
- Hepatitis.
- Leukemia, agranulocytosis, hemolytic anemia.
- Allergic rhinitis, urticaria, anaphylactic shock.
- Irit, choroiditis.
- Iridocyclitis.
Before using the drug, you must definitely study the instructions. Candles "Prednisolone" can be used to prevent the development of relapse or complications after surgery, which was aimed at removing hemorrhoids.
Contraindications
The instructions for Prednisolone suppositories indicate that it is better not to use this medication for those patients who have been diagnosed with the following diseases:
- Digestive system damage: ulcer, abscesses, diverticulitis.
- Diseases of a parasitic or infectious nature. This applies to amoebiasis, tuberculosis, measles, as well as mycosis.
- The acute form of psychosis.
- Arterial hypertension, a chronic form of heart failure, recent myocardial infarction.
- Diabetes mellitus, hypothyroidism.
- Hypoalbuminemia.
- Glaucoma.
- Obesity is the last stage.
- Urolithiasis, severe forms of hepatic or renal failure.
- Polio.
- Eye diseases, open-angle glaucoma.
Rectal suppositories with prednisone are strictly forbidden to use before vaccination and within 14 days after it. The drug can adversely affect the condition of pregnant women, as well as newborns who are breast-fed.
Mode of application
In the instructions for use with Prednisolone suppositories, manufacturers indicated that before the procedure, the patient must cleanse the intestines with an enema. The suppository is introduced into the anus only in the supine position. At this time, it is advisable to press the knees to the chest. It is necessary to observe elementary rules of personal hygiene, as well as to exclude any sudden movements during the introduction of candles. The patient should ensure that the base of the suppository is outside, for this it is held with a napkin. Most often, the procedure is performed twice a day. After the introduction of the suppository, you need to lie down for at least 40 minutes.
Side effects
Suppositories from hemorrhoids with prednisone are actively used in modern medicine, but negative reactions of the body can occur if the patient has exceeded the dosage and duration of treatment. Most often in this situation, the following symptoms appear:
- Slow wound healing.
- Increased appetite.
- A slight increase in blood sugar.
- Decreased resistance to various infections.
- Increased anxiety, headache, nervousness.
In rare cases, the following manifestations are possible:
- Arterial hypertension.
- Heat in the body, hiccups.
- Allergic reactions.
- Fainting, dizziness.
- Increased sweating, lightening skin color around the anus.
- Severe joint pain.
Numerous reviews about Prednisolone suppositories indicate that if you take the drug for 5 weeks without interruptions or significantly exceed the allowable dosage, then there will inevitably be a risk of systemic disorders in the body. In this situation, adrenal function is inhibited, which increases the risk of developing Itsenko-Cushing's syndrome. The patient may experience bradycardia, arrhythmia, as well as disorders of the cardiovascular system.
The use of a large dose of the hormone can provoke a violation of the water-salt balance in the body, as well as cause the development of glycosuria and hyperglycemia. A medication can be the main cause of menstrual irregularities. Patients with diabetes may need an extra dose of insulin. Long-term use of a glucocorticosteroid provokes a significant increase in blood pressure, and also increases the risk of developing heart failure, steroid myopathy, thrombosis, osteoporosis. Suppositories can be the main reason for a decrease in muscle mass in a patient.
The digestive system can specifically respond to the action of the drug. Experts do not exclude the development of vomiting, nausea, steroid ulcers, as well as pancreatitis. A hormonal agent can be the main cause of skin atrophy, the appearance of hyperpigmentation, as well as increased sweating.
special instructions
The instruction for rectal suppositories with prednisone contains information that discontinuation of therapy can provoke the development of withdrawal syndrome, because of which it is necessary to carefully observe all the recommendations of the attending physician regarding the dosage. At the time of treatment, it is worth completely abandoning the use of alcoholic beverages. In addition, the medicine can reduce the rate of psychomotor reactions, which is fraught with the development of hallucinations. That is why for the duration of therapy it is better to abandon driving.
The principle of interaction with other medicines
Universal glucocorticosteroid interacts with various drugs:
- In combination with diuretics, electrolyte imbalance is exacerbated.
- Combination therapy with salicylates increases the risk of bleeding.
- In gynecology, Prednisolone suppositories are forbidden to combine with hormonal contraceptives, as this is fraught with an increased risk of developing undesirable effects of both drugs.
- Hypoglycemic drugs provoke a decrease in glucose.
- Antipsychotic medications increase the risk of cataracts.
Patients should always remember that Prednisolone interacts with various medications, which is why there is always a risk of developing unwanted effects.
Consequences of an overdose
Even the most effective and safe means can cause great harm to the body with significant excesses of the allowable dosage. That is why only any specialist should make any adjustments to the treatment course. Otherwise, the development of disturbances in the cardiovascular system is not ruled out.
Use during pregnancy
High-quality vaginal suppositories with prednisone are strictly contraindicated in the first trimester of gestation. In all other cases, the drug is prescribed for health reasons. During breastfeeding, suppositories can only be used if the expected benefits significantly exceed the potential risk. For the duration of therapy, the baby is better to switch to artificial nutrition.
Treating small patients
Only Prednisoloneum can prescribe a child's suppository. The components of the drug can adversely affect the growth processes in childhood, which is why this hormonal drug is used only in the presence of serious indications and only under the supervision of a qualified doctor. Parents need to remember that such a medication is used only in acute conditions, because of which the dosage should be minimal. It is forbidden to use suppositories longer than the prescribed time. To treat children, experts recommend choosing more appropriate medications that will not harm the unformed body.