Nitroxoline is an antimicrobial drug that has a wide spectrum of influence, which enables it to effectively cope with pathogenic bacteria and other microbes, for example, trichomonads, Candida fungi, etc. That is why the indications of Nitroxoline are infections of the genitourinary system, including urethritis, cystitis, epididymitis, pyelonephritis, prostate carcinoma or infected adenoma, prostatitis.
Structure
The drug is currently produced in only one dosage form - in the form of tablets intended for internal use. They are coated with various shades of yellow-orange or orange. Externally - biconvex, clearly visible three layers in the section. As an active ingredient in each tablet of the drug contains fifty milligrams of Nitroxoline.
Thus, 50 mg of the main substance per tablet. Auxiliary ingredients are compounds such as: potato starch, lactose, corn starch, magnesium stearate, talc, colloidal silicon dioxide, granulated sugar, titanium dioxide, povidone-25, edible gelatin, magnesium carbonate, red dye acid 2C, tropeolin O, macragol 6000.
Consider in more detail the evidence of Nitroxoline.
When is the medicine used?
The drug is recommended in such cases:
- In the treatment of acute, recurring and chronic infections affecting the urinary tract and caused by gram-negative and gram-positive fungi and / or bacteria that are sensitive to Nitroxoline.
- In the prevention of a number of infections during various interventions (cystoscopy, catheterization, infection prevention after surgery on the genitourinary tract and kidneys).
- In the prevention of infections of the recurrent nature of the urinary tract, especially in small patients. Indications "Nitroxoline" are indicated in the instructions.
Contraindications
As contraindications to the appointment are:
- cataract;
- serious renal failure (creatinine clearance less than 0.33 ml / min);
- hypersensitivity to quinolines;
- high sensitivity to nitroxoline or auxiliary components.
Pregnancy and lactation time
Clinical studies confirming the safety of the use of Nitroxoline for cystitis during pregnancy do not exist. That is why using it at this time is not recommended. The safety and effectiveness of the drug during lactation also has no confirmation, so you should limit the use of this drug.
What else does the instructions for use with Nitroxoline tell us?
At what dosage is the drug taken?
Adult patients need to take from 400 to 800 mg per day, divided into four doses. On average, the dosage of Nitroxoline is 400 mg. The drug is taken in two coated tablets before meals four times a day. If necessary, treatment is continued either with intermittent courses (two weeks per month), or continuously. In serious cases, you can double the dosage, but it should not be higher than 200 mg four times a day.
Can I give Nitroxoline to children? Small patients older than five years of age are prescribed the usual dose of 200 to 400 mg, also divided into four doses. If the body weight of the child is more than eight kilograms, then 200 mg four times.
In case of renal failure, the doses are as follows: for people with a moderate degree of the disease (creatinine clearance greater than 0.33 ml / min), the usual dose is divided in half (four times a day, one tablet).
In case of liver failure, the usual dose should be divided into two (take the same), following the indications. "Nitroxoline" should be taken according to the scheme with all the precautions.
Side effects when taken
The drug can cause side symptoms from those or other systems and organs:
- gastrointestinal tract: decreased or loss of appetite, vomiting, nausea, impaired liver function (in rare cases);
- immune system: skin rashes, itching;
- peripheral and central nervous system: headaches, ataxia (when the balance and coordination of muscle movements are disturbed, due to which the patient loses balance, awkward gait, etc.), paresthesia (sensory defects and sensation of running “goose bumps”), nerve neuritis eye (only with prolonged use of the drug), polyneuropathy;
- system of vessels and heart: tachycardia;
- other signs: staining of urine in a yellow-red tint.
This is confirmed by the instructions for the use of Nitroxoline.
Drugs with a similar effect
Currently, there are drugs with a similar effect. Analogues are those drugs that, like us, as an active substance, include nitroxoline. Also, they include drugs containing other active substances, but with a similar therapeutic effect.
We list the main analogues of Nitroxoline:
- 5-NOC;
- Nitroxolin-UBF;
- 5-Nitrox;
- Nitroxolin-AKOS;
- Amizolid tablets - for internal use;
- tincture "Galenofillipt" for oral administration;
- tablets and solution for intravenous administration "Hexamethylenetetramine";
- Dixin solution for external use and introduction into the cavity;
- Dioxidin solutions - for intravenous, as well as external and cavity use;
- analogue of "Nitroxoline" "Zenix";
- Zivox tablets - granules intended for the manufacture of a suspension for internal use, as well as a solution for injecting into a vein;
- Kirin powder for the manufacture of a suspension intended for intravenous administration;
- Lifizilat "Kubitsin" to create a solution for intravenous use;
- granules "Monural" for the preparation of a solution for internal administration;
- ristomycin sulfate lyophilisate to create an injection solution;
- Sanguirythrin tablets;
- Urofosfabol powder for solution for injection;
- Fosfomycin powder - for the manufacture of a solution for intravenous administration;
- tincture of eucalyptus;
- Linezolid-Teva solution for injection into a vein.
Reviews about Nitroxoline
The overwhelming number of reviews about the drug is positive, since this has its excellent properties. So, both women and men who used the drug, note the following advantages: low cost, effectiveness, the possibility of cure for adnexitis and cystitis in one course, safety in use.
In addition, almost all patients in positive reviews write that "Nitroxoline" with cystitis is effective against a wide range of kidney diseases, inflammation of the genitals and urinary tract. Since the inflammatory processes of these systems occur simultaneously, the drug is very convenient because it allows you to treat them together. Thanks to such therapeutic advantages, Nitroxoline in most cases gains positive reviews.
Sometimes patients indicate drug deficiencies. These include: the need to be treated for quite a long time, staining urine in an unpleasant yellow-red hue, side effects, quite uncomfortable and painful. But, according to people, against the background of its effectiveness and ability to treat several pathologies at once and low cost, all these shortcomings do not affect the quality of the drug as a whole.
Are there any negative comments about this drug? There are few negative reviews about Nitroxoline. The reason for them is the ineffectiveness of the drug in a specific situation, with the unattained positive effect of the treatment. In addition, patients who respond negatively to the medication note the fact that the effect of the drug develops for a long time, and therefore have to endure uncomfortable symptoms for a long time. In addition, people are not always unhappy that you need to take this drug for a long period.