What is the use of the Kutivate drug (ointment)? Instructions for the use of the medication, its analogues, indications, release forms and composition will be described in this article. From it you will learn about how much this remedy costs, what contraindications it has, whether there are side effects, etc.
Composition, release forms, description and packaging
What components does the Kutivate medicine (ointment) include? Instructions for use say that the active substance of this form of the drug is fluticasone propionate. It also includes sorbitan sesquioleate, liquid paraffin and microcrystalline wax.
Translucent and homogeneous ointment is intended for external use only. It has a white or almost white color. The drug is sold in aluminum tubes (15 g), which are in cardboard packaging.
What other form of Kutivate medicine is produced?
Cream for external use (0.05%) has a uniform and soft consistency, as well as white or almost white color. The active component of this form is also fluticasone propionate. In addition, the preparation includes excipients such as sodium phosphate, liquid paraffin, cetostearyl alcohol, isopropyl myristate, propylene glycol, ketomacrogol, imidourea, citric acid monohydrate and purified water.
The drug goes on sale in aluminum tubes (15 g), placed in cardboard boxes.
In addition to the two listed forms of medication, in pharmacies you can also find other types of Kutivate - nasal spray and aerosol for inhalation. The active substances of the mentioned preparations are the same components as in the ointment with cream. However, their purpose is somewhat different.
Pharmacological characteristics
What is Kutivate medicine? Hormonal or not this drug? According to experts, this medication is a glucocorticosteroid with a pronounced anti-inflammatory effect.
As mentioned above, all forms of the drug in question contain such an active component as fluticasone propionate. This is a glucocorticosteroid substance. When applied topically, it eliminates burning, redness and itching, and also markedly reduces the intensity of existing inflammation.
With external use, the drug has a pronounced decongestant and anti-allergic effect. In this case, there is no negative effect of the said agent on the cardiovascular, respiratory and nervous systems.
Pharmacokinetics
Is the Kutivate medicine (ointment) absorbed? Instructions for use say that when used externally, the bioavailability of fluticasone propionate is quite low. This is due to its limited absorption through the skin, as well as intense metabolism during passage through the liver.
The medication, which entered the systemic circulation after application to the skin, is inactivated quite quickly. In this regard, its systemic effect is minimal.
The main route of drug metabolism is hydrolysis to carboxylic acid. The formed metabolite has a rather weak glucocorticoid activity. The active substance of the drug does not bind to melanin and does not accumulate in the tissues.
Fluticasone propionate is excreted rather quickly, and also has a very high metabolic clearance.
Indications for use of cream and ointment
In what cases is the hormonal drug Kutiveyt prescribed (ointment)? Instructions for use inform patients that this drug is used to treat skin diseases.
Thus, the following deviations are indications for the use of the mentioned forms of medication:
- atopic dermatitis;
- eczema;
- seborrheic dermatitis ;
- psoriasis;
- erythroderma (in addition to systemic therapy);
- contact dermatitis;
- lichen planus;
- neurodermatosis, including simple lichen;
- discoid lupus erythematosus;
- insect bites.
Allergic dermatosis is allowed to be treated with cream in children older than one year. As for the ointment, this form of the drug can be prescribed to babies from 6 months.
Indications for use of nasal spray and aerosol
In what cases can a Kutivate spray be prescribed to a patient? Reviews of experts say that a nasal remedy perfectly treats allergic rhinitis. As for the aerosol, it is actively used to prevent exacerbations of bronchial asthma.
Contraindications to the use of all forms of the drug
In the presence of any deviations, is it forbidden to use the Kutivate medication (cream, ointment, spray, aerosol)? According to the instructions, all forms of the product can not be used when:
- pink eels;
- common eels;
- in children under one year for cream, up to 6 months for ointment and up to 4 years for spray;
- perioral dermatitis;
- viral and fungal infections of the skin;
- perianal and genital itching;
- hypersensitivity to the substances means.
It should also be noted that the funds under consideration should be prescribed with special care during pregnancy and during lactation.
Methods of applying ointment and cream
How should I use the external preparation "Kutivate"? The use of ointment and cream should be carried out only as prescribed by the doctor. In the treatment of chronic and acute dermatoses, the drug is applied to the affected area with a thin layer twice a day. The duration of use of the hormonal drug is two weeks.
To reduce the recurrence of a disease such as allergic dermatosis, after the therapeutic effect is achieved, the frequency of applying the ointment and cream is reduced. In this case, the drug should be used once twice a week. In this case, occlusive dressings should be excluded.
It should also be noted that the ointment and cream must be applied to all previously affected areas of the skin, as well as to those where the disease may occur.
Methods of use and dosage of spray and aerosol
How should I use the local drug โKutivateโ (the price of the drug is presented a bit further)? For adults, it is recommended to use the nasal spray in the morning at 100 mcg in each nostril, and for children under 12 years old - at 50 mcg.
As for the aerosol for inhalation, for moderate, mild and severe bronchial asthma, the drug in this form is prescribed twice a day, 250-500 ฮผg, 100-250 ฮผg and 500 ฮผg, respectively. Adolescents under 16 years of age need to use 50-100 mcg.
Overdose
The likelihood of acute overdose by the considered drugs is extremely low. But with improper use or chronic overdose in a patient, signs of hypercorticism may develop. In this case, the use of the medication should be stopped immediately. However, the drug should be discontinued gradually, under the supervision of the attending physician (in order to avoid the risk of inhibition of the adrenal cortex).
Side effects after using ointment and cream
Does Kutivate Medication have side effects ? Reviews of specialists inform that in some cases this drug really contributes to the appearance of unwanted reactions. Among them, the following can be noted:
- Local reactions: atrophic changes in the skin (hypertrichosis, thinning, vasodilation, hypopigmentation and striae), itching, burning, exacerbation of signs of dermatosis, the development of contact and allergic dermatitis, as well as secondary infections (when applying occlusive dressings).
- Systemic reactions: symptomatic hypercorticism (with prolonged use of the drug in high doses, as well as when applying the external agent to large areas of the skin). Most often, such a side effect is observed in young and young children, as well as when using occlusive dressings. Very rarely, the use of ointments and cream can provoke the development of pustular forms of psoriasis.
Side effects after using spray and aerosols
The nasal spray often causes irritation of the nasopharynx, perforation of the nasal septum, as well as a feeling of an unpleasant aftertaste and smell. As for the aerosol for inhalation, this form of the drug contributes to the appearance of candidiasis of the oral mucosa, hoarseness and the development of paradoxical bronchospasm.
special instructions
Long-term use of ointment and cream in high doses, especially if the medicine was applied to large areas of the skin (especially in children), can cause suppression of adrenal cortex function.
High absorption of the external drug in children is observed more often than in adults. Therefore, they are more susceptible to the systemic effects of the drug. In this regard, such a tool should be used in small doses, which provide a therapeutic effect.
With long external use, atrophic changes most often occur on the face. This fact should be taken into account during the treatment of such abnormalities as discoid lupus erythematosus, psoriasis and severe eczema.
When applying ointment and cream on the eyelids, it is necessary to avoid getting the medication in the eyes, as this can cause glaucoma or local irritation.
With extreme caution, an aerosol for inhalation is prescribed for pulmonary tuberculosis. In this case, treatment should not be abruptly abolished.
Nasal spray should be used at regular intervals.
The drug "Kutivate": analogues and prices
The following medicines act as analogues of the drugs under consideration: Nazarel, Fluticasone Propionate, Flixonase, Fluticasone and Flixotide.
How much does Kutivate cost? The price of different forms of the drug can vary significantly. For example, ointment can be purchased for 290 Russian rubles, and cream - for 330.
Approximately the same prices have a nasal spray and aerosol for inhalation.
Reviews about the tool
The drug "Kutivate" is a hormonal agent. This fact is very scary for the patients to whom he was appointed. However, after the first use, they note its high efficiency.
According to patients' reviews, ointment and cream quite quickly treat all types of allergic dermatosis. Also, aerosol spray can also cope well with the task.
However, it should be noted that there is such a category of people who complain about the appearance of a large number of side effects. In this case, patients are advised to cancel the use of the drug and use a safer analogue.