How should I use the drug "Reosorbilact"? Instructions and indications for the use of the mentioned funds will be presented a little below. We will also tell you about the form in which this medication is released, what is its cost, whether it has analogues, side effects and contraindications.
Release form, description, packaging and composition of the drug
In what form is a drug such as Reosorbilact released? The instructions accompanying this drug state that it goes on sale in the form of a colorless as well as a clear solution for infusion.
The active substances of this medicine are: sodium lactate, magnesium chloride, sorbitol, calcium chloride, sodium chloride and potassium chloride. Also, such an auxiliary component as distilled water is also part of this medication.
The drug is sold in glass bottles, which are placed in cardboard packaging.
Pharmacodynamics
What is the medicine "Reosorbilact"? The instruction informs that it is a plasma substitute. It has anti-shock, rheological, alkalizing and detoxifying effects. The main pharmacologically active elements of this drug are sodium lactate and sorbitol.
Entering the liver, the last component is first converted to fructose, and then sequentially to glucose and glycogen. It should also be noted that one part of sorbitol is consumed by the body for energy needs, and the other is stored as glycogen.
An isotonic solution of this substance has a disaggregant effect. It improves perfusion and tissue microcirculation.
Unlike bicarbonate solution, the correction of acidosis (metabolic) with sodium lactate is much slower, as it is included in the metabolism. In this case, sharp fluctuations in pH does not occur. The action of the substance is manifested approximately 25-30 minutes after administration.
What other properties does the medicine “Reosorbilact” have? The instruction states that calcium chloride, which is part of the drug, is able to eliminate the deficiency of calcium ions, which are essential for contracting smooth and skeletal muscles, blood coagulation, transmission of nerve impulses, myocardial function and bone formation.
It should also be noted that the substance in question lowers the permeability of the vascular walls and cells, prevents the development of inflammatory processes, significantly enhances phagocytosis, and also increases the resistance of the human body to various infections.
Sodium chloride is a kind of plasma substitute. It exhibits rehydration and detoxification properties. The drug eliminates the deficit of chlorine and sodium ions, which occurs in various pathological conditions.
Potassium chloride is able to restore electrolyte and water balance. It exhibits a negative batmo- and chronotropic effect, and in high doses, a negative dromo- and inotropic diuretic effect (moderate severity).
The component under consideration is directly involved in the processes of nerve impulses. It increases the content of acetylcholine, and also contributes to the excitation of the sympathetic part of the autonomic system. Also, the component under consideration improves the processes of skeletal muscle contraction during myasthenia gravis and muscular dystrophy.
Pharmacokinetic properties
Is Reosorbilact absorbed? The instruction (the price of the solution is presented a little further) states that sorbitol is quickly included in the general metabolism of the body. Approximately 80-90% of the active substance is utilized in the liver. In the same organ, sorbitol accumulates in the form of glycogen.
It should also be noted that 5% of the drug is deposited in the heart muscle, brain tissue and skeletal muscle. About 7-12% of the drug is excreted in the urine.
After the drug is introduced into the vascular bed of sodium, lactate immediately begins to interact with water and carbon dioxide, forming sodium bicarbonate. This process leads to an increase in the alkaline reserve of blood.
Only ½ of the injected sodium lactate is active. As for the other half, it is not metabolized and excreted along with urine.
Indications
In what cases is the drug "Reosorbilact" prescribed? Instructions for use (the price of this tool is not very high) includes the following indications:
- sepsis;
- traumatic, operational, hemolytic, toxic and burn shock, acute blood loss, burn disease;
- to improve the blood flow of capillaries (with a preventive purpose);
- infectious diseases, which are accompanied by exacerbation of chronic hepatitis and intoxication;
- Raynaud's disease;
- to improve venous and arterial circulation with a preventive purpose;
- treatment of thrombophlebitis, thrombosis and endarteritis;
- in the postoperative period;
- for preoperative preparation.
Contraindications
What abnormalities should not be used with the Reosorbilact medication (200, 400 ml)? According to the instructions, the following conditions are contraindications for the drug in question:
- alkalosis;
- if a large amount of fluid is contraindicated for the patient (for example, with thromboembolism, cerebral hemorrhage, cardiovascular decompensation, grade 3 arterial hypertension);
- hypersensitivity to drug substances.
It should also be noted that the medication under consideration is prescribed with special care to patients with impaired liver function, hemorrhagic colitis and peptic ulcer.
Dosage of the drug and methods of its use
In case of burn, traumatic, hemolytic and postoperative shocks, the Reosorbilact dropper is prescribed once in a volume of 600-1000 ml.
In chronic hepatitis, the dose of the drug is 400 ml.
In acute blood loss, the drug is prescribed for 1500-1800 ml.
After surgery, as well as in the preoperative period, the drug is administered dropwise in a volume of 400 ml. The procedure is carried out daily for 4-5 days.
With thrombobliterative deviations of blood vessels, the medication is prescribed at the rate of 8-10 ml per kg of patient weight. The drug is administered drip every other day. The duration of therapy is up to 10 infusions.
For children under six years of age, the drug in question is recommended to be used in a dosage of 10 ml per kg of body weight. Children from 6 to 12 years of age are prescribed the drug in half dose for adults.
Side effects
Does the drug “Reosorbilact” cause side effects? Analogs and the tool itself are almost never the cause of unwanted effects. However, in some cases, patients may still experience alkalosis and allergic reactions in the form of itching and skin rash.
Features of the drug
The drug in question should be used only as directed by the doctor. Moreover, the solution must be administered only under the control of indicators of blood electrolytes and the acid-base state of the body, as well as liver function.
With extreme caution, this medication is prescribed for patients with calculous cholecystitis.
Terms, methods and conditions of storage
The medication in question belongs to list B. This drug should only be stored in a dark place, dry and out of the reach of children. The storage temperature of the drug is from 5 ° to 26 ° C. Shelf life is two years. After the specified period, the use of medication is prohibited.
The drug "Reosorbilact": price and analogues
Synonyms and analogues of the drug "Reosorbilact" are sold in all pharmacies. Among the most common and effective agents, the following drugs can be distinguished: Sorbilact, Potassium chloride, Potassium chloride buffus, Calcium chloride, Consol, Kormagnesin, Custodiol, Magnesium sulfate.
How much does the Reosorbilact drug solution cost? The price of this tool in pharmacies may vary for various reasons. However, on average, such a drug costs about 200 rubles (200 ml).
Drug Reviews
According to patients' reviews, the Reosorbilact drug solution effectively treats acute blood loss, sepsis, burn diseases, infectious diseases, and also eliminates the shock condition. Another advantage of this drug is that it almost never causes side effects. Although in some cases it nevertheless causes allergic reactions.