"Andipal" refers to the category of combined medications that have a vasodilator, antispasmodic and analgesic effect.
As an antispasmodic, the drug is used for spasms of blood vessels in the brain and peripheral. Reducing OPSS, acting on arterioles. This medication reduces blood pressure, normalizes collateral circulation. The complex of antispasmodics of the myotropic group (papaverine hydrochloride and dibazole) with analgin increases the analgesic effect in migraines and headaches. The presence of phenobarbital in the drug promotes the development of a sedative effect and enhances the effects of other components.
In the article, we consider the instructions for use with Andipalau, contraindications and side effects.
Composition and form of release
This drug is produced in the form of white tablets with a slight yellowish tinge. They are flat cylindrical in shape, with a notch and a chamfer. The composition of the medicine includes the main active elements:
- Sodium metamizole.
- Bendazole
- Phenobarbital.
- Papaverine hydrochloride.
As additional substances in the production of this product, potato starch, talc, stearic acid, calcium stearate are used.
Contraindications to Andipal should be strictly observed. One of them is the patient's hypersensitivity to any of the listed substances.
10 tablets are packaged in blisters. Each cardboard pack can contain 1 or 2 blisters.
Contraindications to Andipal and side effects are described in detail in the instructions.
Pharmacological properties
This is a combination drug. The combination of the components of the composition leads to a mutual strengthening of their pharmacological effects.
Metamizole sodium is represented by a pyrazolone derivative, which has an antipyretic and analgesic effect.
Bendazole (dibazole) is a vasodilating substance with a vasodilating property, it stimulates the functional qualities of the spinal cord, has a direct antispasmodic effect on the smooth muscles of various organs and blood vessels, and facilitates synaptic transmission processes in the spinal cord.
Papaverine hydrochloride is an antispasmodic substance that has hypotensive properties, relaxes and reduces the tone of the smooth muscles of blood vessels and internal organs.
Phenobarbital, in small doses, has a sedative effect and enhances the properties of other structural components of the drug.
Before talking about contraindications of Andipal tablets, we will describe in what cases they are prescribed.
Indications
This medication is prescribed to patients in the following cases:
- Pain (moderate or weak) during spasm of the smooth muscles of internal organs: biliary, renal or intestinal colic, biliary dyskinesia, algodismenorrhea, postcholecystectomy, bladder and ureter spasms.
- Vascular spasms in the brain, migraine.
- As an additional drug for pain after surgery and invasive diagnostic procedures.
The main indication for the use of Andipal is high blood pressure.
If we talk about professional symptoms, then it is often observed in intellectual workers, teachers. In addition, drivers often suffer from hypertension.
Contraindications to Andipal must be considered before appointment.
In the case of driving, it is recommended to observe the dosage of the medication and in no case to exceed them, since there is a likelihood of an adverse reaction in the form of a decrease in the speed of reactions.
If high blood pressure is a consequence of fatigue or work, then this tool will quickly help normalize the condition and well-being.
Contraindications to Andipal
The medicine is not used for such pathological conditions:
- High sensitivity to the substances which are a part.
- Inhibition of hematopoiesis in the bone marrow.
- Severe renal / hepatic insufficiency.
- Age less than 18 years.
- Glucose-6-phosphate dehydrogenase deficiency.
- Tachycardia, arrhythmia.
- Pregnancy, lactation.
- Severe angina pectoris.
- Chronic decompensated heart failure.
- Angle-closure glaucoma.
- Intestinal obstruction.
- Hyperplasia of the prostate gland.
A doctor with these pathologies should choose another drug.
Use in pregnant women
Are there any contraindications to Andipal during pregnancy? This is an effective drug, the use of which allows you to eliminate the unpleasant and painful symptoms of migraine, as well as manifestations of mild forms of hypertensive conditions during the expectation of a child. However, this drug should not be taken. Pregnancy is one of the contraindications to this drug, especially in the first trimester, when all the organs of the child are formed.
Dosing and Administration
The medication is taken orally. Adult patients are prescribed 1 tablet 2-3 times a day. The duration of a therapeutic course without consulting a specialist should not be more than 1 week.
If contraindications are not observed, Andipal tablets can provoke negative reactions of the body.
Side effects of the drug
This pharmacological drug can provoke the occurrence of the following adverse reactions of the body:
- Digestive system: constipation, nausea.
- Allergic reactions.
- Prolonged use causes agranulocytosis, leukopenia, impaired liver and kidney function.
- CNS: decreased speed of psychomotor reactions, increased drowsiness.
Special recommendations
Contraindications to the use of "Andipal" we have described. It is also important to follow the instructions and be careful with prolonged use.
When using this medication for more than 7 days, it is necessary to monitor the functional state of the liver and the clinical picture of peripheral blood. In the absence of a positive therapeutic effect within 3 days, it is recommended to stop taking the drug and consult a specialist. During the treatment period, it is necessary to limit classes to potentially dangerous types of activities that require a high concentration of attention and speed of reactions, or to completely eliminate them.
For patients under the age of 18, the medication should be taken only on the recommendation of a doctor.
Drug interaction
Acceptance of the Andipal drug in combination with nitrates (Nitrosorbide, Nitroglycerin, Sustak, etc.), beta-blockers (Metoprolol, Anaprilin, Talalinol, etc.), calcium channel blockers (Corinfar, Nifedipine, etc.), diuretics (Hypothiazide, Furosemide, etc.), ganglion blockers (Pentamine), myotropic antispasmodics (Eufillin, Dipyridamole) enhances the hypotensive effect of these medical funds.
The use of the medication in question with other non-narcotic analgesics can provoke a mutual increase in toxic effects.
The simultaneous use of the Andipal drug with adsorbents, as well as with enveloping and astringent agents, reduces the level of absorption of the drug in the digestive tract.
Analogs
There are a lot of drugs identical to the Andipal remedy in the modern pharmaceutical market. These are combined analgesics that differ in composition, but to one degree or another have the same effects: anti-inflammatory, analgesic, antispasmodic, antipyretic. The analogues of the drug include:
- "Spazmalgon" is a medication that is a combination of a non-steroidal anti-inflammatory substance, an M-anticholinergic antispasmodic and an antispasmodic. According to the principle of action, this drug belongs to the category of analgesics with a pronounced antispasmodic property.
- "Took" - a combined medication from the group of non-narcotic analgesics and antispasmodics. Its therapeutic effect is provided by 3 active elements: metamizole sodium (it has an antipyretic and analgesic effect due to the blockade of the production of anti-inflammatory prostaglandins), fenpiverinia bromide (blocks M-cholinergic receptors, as a result of which muscle tone is reduced and its spasm is eliminated), pitophenone hydrochloride (affects smooth muscle tone muscles of hollow organs, leading to a decrease in the severity of spasm).
- "Maksigan" is a combined drug with analgesic and antispasmodic effect. The composition of this medication contains substances that have analgesic, antipyretic, anti-inflammatory, myotropic and relaxing properties. The combination of all components of the drug leads to a mutual increase in their pharmacological effect, which is expressed in pain relief, lowering temperature and blood pressure.
- "Revalgin" is a complex analgesic and antispasmodic medical device, the principle of action of which is based on the properties of its active elements. Pitophenone is an antispasmodic with a bright myotropic property similar to papaverine. Helps to reduce tone and eliminate spasms in the smooth muscle layer of internal organs, provides an analgesic effect in spastic pain. Another active substance is fenpiverinium bromide. It is an anticholinergic, which helps to relax the walls of blood vessels and organs. Metamizole sodium is a substance that is a non-steroidal anti-inflammatory compound. It provides analgesic, antipyretic and anti-inflammatory effects, inhibits the production of cytokines, which leads to a pronounced decrease in the intensity of the inflammatory process. The active elements of this medication complement each other, enhancing the therapeutic effect.
We learn what people think about contraindications to Andipal and side effects.
Reviews
The medication in question is a fairly popular remedy. It effectively reduces high blood pressure, as evidenced by the numerous reviews of patients. Doctors note that the antihypertensive property of Andipal is due to its ability to relax the vascular walls, which leads to a decrease in pressure, that is, it is already a secondary effect of the drug.
This can be understood by the indications for the use of Andipal.
In the reviews, patients note that the medicine is an indispensable antispasmodic. Many people have it in their home medicine cabinet. People use it for headaches and abdominal pains, for cholecystitis, pancreatitis, colitis, etc. It is also known about the high effectiveness of this medication for pain in the kidneys caused by the release of stones. Analgesic well removes discomfort in the area of the ureters and bladder.
As a rule, this medication is well tolerated by patients. In the reviews, they indicate that the medicine rarely provokes side effects. The most common negative phenomenon with it is the symptoms of dyspepsia. Some patients showed slight dizziness and weakness, as well as a short-term digestive disturbance. As an advantage of the drug, people note its low cost. You can buy Andipal at any pharmacy by paying about 50 rubles for 10 tablets.
We examined the main contraindications to Andipal and the instructions for the drug.