Unfortunately, hormonal disorders in women are observed quite often. And in such cases, doctors usually recommend drugs that can normalize hormone levels. The Prajisan remedy also belongs to this group. Instructions for use, indications and contraindications, side effects, price, reviews - all of these issues are of interest to women. So what exactly is this drug?
Composition and form of release of the drug
This medicine is available in the form of soft yellow gelatin capsules. Inside the capsule contains an oily suspension of white color. The main active substance of the drug is progesterone. In the pharmacy you can buy capsules with a dose of 100 or 200 mg of this component.
Naturally, some excipients are present in the composition, in particular, soya lecithin and peanut butter. The shell consists of a 70% non-crystallized solution of sorbitol, gelatin, purified water, glycerol and titanium dioxide. Capsules are placed in blisters of ten pieces. In one package can be 10 or 30 tablets.
In addition, this drug is also available in the form of a special vaginal gel with convenient disposable applicators. In any case, the question of how and in what form you will take the medicine is decided by the attending physician.
The main pharmacological properties
The main active substance is progesterone - the hormone of the corpus luteum, which performs many important functions. In particular, it ensures the transition of the uterine mucosa from the proliferation phase to the secretory phase. After fertilization, the hormone provides conditions for the normal development of the embryo, and also reduces the contractility of the muscles of the uterus and fallopian tubes, stimulates the development of the mammary gland.
This substance also ensures the normal development of the endometrium, increases subcutaneous fat stores, increases glucose utilization, and contributes to the accumulation of glycogen in liver tissues.
After administration, the drug is well absorbed by the walls of the digestive tract. Its maximum concentration in the blood is observed after 1 - 3 hours. Metabolic processes occur in the liver, after which the formed metabolites are almost completely excreted along with urine.
With vaginal administration of the drug, progesterone is also rapidly adsorbed and partially accumulates in the tissues of the uterus.
Indications for use
In what cases it is advisable to take the drug "Prajisan". The instruction indicates that the drug is widely used to treat secondary amenorrhea, as well as various dysfunctional uterine bleeding that arose against a background of progesterone deficiency. In addition, it is used to treat infertility, which developed against a background of luteal insufficiency.
These are far from all cases in which doctors prescribe Prajisan. Its use is quite common with substitution therapy against the background of menopause. Naturally, in this case it is used together with other hormonal drugs.
The drug "Prajisan": instructions for use
The dosage, the schedule of administration and the duration of therapy are determined only by the attending physician - doing it yourself is strictly contraindicated. In case of progesterone deficiency, as a rule, a daily dose of 200 to 300 mg is prescribed, which should be divided into two doses. In case of luteal phase insufficiency, the maximum daily dose is 400 mg of progesterone. The duration of therapy for a similar problem is 10 days.
By the way, capsules can be taken not only orally. Sometimes doctors recommend using Prajisan vaginally, dipping the capsule deep into the vagina. A similar procedure is indicated for absolute progesterone deficiency, as well as to support the luteal phase and in preparation for in vitro fertilization.
Can I use the drug during pregnancy?
Quite often, women ask whether Pragisan can be taken during pregnancy. According to the instructions, this period of a woman’s life is not a contraindication to therapy. Moreover, in some cases its use is necessary. After all, a decrease in the level of progesterone in the body in the early stages of fetal development can lead to termination of pregnancy. This medicine may help avoid this complication.
But it is worthwhile to understand that only a doctor is entitled to prescribe the Prajisan remedy during pregnancy. The specialist will also determine the most effective and safe dose of the medicine.
By the way, drugs containing progesterone are often prescribed to women during pregnancy planning.
Contraindications
Can Prajisan be used for all categories of patients? The instruction indicates that there are contraindications in this case, so be sure to read their list before starting therapy.
To begin with, it is worth saying that the medicine is not prescribed for patients who have hypersensitivity to any of its constituent components. Contraindications also include vaginal bleeding of unknown etiology, as well as malignant neoplasms of the reproductive system or mammary glands. The drug is not prescribed in the presence of porphyria, acute thrombosis, thrombophlebitis and thromboembolism. Incomplete abortion is also a contraindication.
Severe violations of the liver, including hepatitis, cholestatic jaundice, hepatic cell carcinoma, can also be complicated by hormones.
There are a number of conditional contraindications, in which therapy is possible only under the close supervision of a doctor. Their list includes depression, bronchial asthma, chronic renal failure, diabetes mellitus, epilepsy, migraines, hypertension, diseases of the cardiovascular system, hyperlipoproteinemia.
Side effects
Many patients are interested in questions about whether any complications are possible when taking Prajisan. The instruction confirms that there is a likelihood of adverse reactions. For example, after the first dose of the medicine, some patients experience drowsiness, sometimes nausea, dizziness. As a rule, such violations go away on their own or after a dose reduction. In addition, during therapy, some women noted a violation of the usual menstrual cycle, as well as tension and some soreness of the mammary glands.
Sometimes Prajisan tablets cause an allergic reaction, which most often manifests itself in the form of skin rashes and redness. Puffiness, urticaria, severe itching are less common.
More serious side effects include persistent fatigue, severe headaches, and fluid retention, and very rarely jaundice. With the introduction of the drug, vaginal irritation of the vaginal mucosa, the appearance of intermenstrual bleeding, and also abdominal pain are not excluded.
Is an overdose possible?
In fact, an overdose of this medicine is extremely rare, since progesterone is a completely natural substance for the female body. In some patients, taking too large doses causes severe drowsiness, dizziness, and menstrual irregularities. If you suspect an overdose, you should seek medical help. Sometimes, to eliminate all the inconveniences, it is enough to reduce the dose or change the method of administration (often doctors transfer patients from oral administration to vaginal administration).
Are there any drug analogues?
For one reason or another, this medicine is not suitable for all women. So what can replace the drug "Prajisan". Suppositories or vaginal capsules "Urozhestan" have almost the same composition and properties. Pretty good analogs are considered such drugs as Progesterone, Krainon, Iprozhin. The main active substance of each of these drugs is the same progesterone. In addition, these funds are also available in the form of tablets, gels, capsules, vaginal suppositories, etc.
How much is the drug?
Many women are interested in questions about how much the drug Prajisan costs. The price will depend on many factors. For example, the cost will vary depending on the city of residence, the manufacturer, the price policy of the pharmacy, the dosage and the form of release of the drug.
So how much will the Prajisan capsules cost? The price of a package of 30 tablets with a dosage of 100 mg of the active substance ranges from 280 to 350 rubles. 10 tablets with a dosage of 200 mg will cost about 250-300 rubles. A tube of vaginal gel costs about 200-250 rubles.
Reviews of patients and doctors
Of course, many women are interested in the reviews of specialists and those patients who have already undergone therapy. In fact, doctors are quite supportive of this medicine. It really helps to eliminate a lot of problems, including infertility and spontaneous abortion. In addition, there are not many contraindications. Most women were also satisfied with the treatment results. The drug rarely causes any side effects, and there are not so many contraindications to therapy. And its undoubted advantage is the relatively affordable cost that everyone can afford.