Currently, pharmaceutical companies offer consumers an extensive selection of a variety of immunomodulating medications. A special place among them is the drug "Galavit". It is produced by a domestic manufacturer and has been used in many medical fields for the past 15 years. The most noteworthy candles are “Galavit”, which are widely used in the field of gynecology. Detailed information will be provided about them.
Rectal suppositories “Galavit” belong to the group of immunomodulators. Leave from pharmacies without a prescription from a doctor.
In Russian pharmacies, the average cost of the drug fluctuates at 850 rubles.
Structure
The drug is available in three forms:
- In tablets, in the composition with sodium aminodihydrophthalazinedione 25 mg, as well as excipients such as lactose, talc, starch, calcium stearate, sorbitol, racementol.
- In powder for the manufacture of a solution with 50 or 100 mg of the active substance in the composition.
- In the form of rectal suppositories, with the active substance 50 or 100 mg in the composition.
The instruction for the Galavit candles is very detailed.
Pharmacological effects
After the introduction of the Galavit suppository into the rectum, rapid absorption of the active component into the systemic circulation is observed. The active substance freely penetrates into all functional tissues of the body. The drug has a local effect:
- Antibody formation is normalized, T-cell immunity is activated.
- Indirectly affects the secretion of endogenous interferons, which are able to engage in the fight against foreign antigens.
- Reversibly blocks the production of inflammatory markers (tumor necrosis, cytokines, etc.).
- The phagocytic activity of macrophages and neutrophils increases - the ability of immunity cells to capture and destroy pathogen cells is significantly increased.
The use of Galavit candles in gynecology is very popular.
The above effects are valid for about 70 hours after using suppositories. The bioavailability of the drug is average, is 61%. Metabolites are excreted mainly by the kidneys.
Indications for use
Candles "Galavit" can be used both for prevention and for the purpose of pathogenetic therapy of the following diseases and conditions:
- Traumatic osteomyelitis.
- Inflammatory pathologies of the gastrointestinal tract, including ulcerative lesions of the duodenum, stomach, ulcerative colitis with a nonspecific course, Crohn's disease.
- Diseases of the inflammatory nature of the urogenital sphere, including urethritis, pyelonephritis, prostatitis, pyelitis.
- Diseases of the inflammatory nature of the genitourinary sphere, including vaginitis, salpingitis and others.
- Intestinal infections, including foodborne toxicosis, dysentery, salmonellosis and other diseases that are accompanied by diarrhea.
- Decreased sexual function due to microcirculation disorders.
- Diseases of an infectious nature, including those having a different etymology of sepsis, purulent meningitis, erysipelas, hepatitis.
- Bronchopulmonary infections, including pneumonia, bronchitis, obstructive bronchitis, bronchial asthma.
- Immunodeficiency conditions. It can be used to correct immunity in cancer patients receiving chemotherapy and radiation therapy.
- A variety of vascular disorders, including endarteritis and its complications, ischemic angiopathy of various organs, diabetic angiopathy.
- Chronic inflammation, including adnexitis, endometritis, rheumatoid arthritis, scleroderma, various etymologies of liver damage.
- Prevention of complications that can develop after surgery.
Contraindications
Galavit suppositories are strictly contraindicated for patients who have individual sensitivity to the components that make up the suppositories. Also for women during pregnancy and during breastfeeding.
It is important to note that “Galavit” is contraindicated throughout the entire period of pregnancy, and not only in certain trimesters. However, rectal suppositories can be prescribed to a pregnant woman when the benefit to the mother outweighs the possible risk to the baby.
Instructions for candles "Galavit"
Suppositories are for rectal administration. Previously, the candle must be removed from the contour packaging, and then inserted into the rectum. It is recommended to empty the intestines before the introduction of the suppository. The duration of the use of Galavit suppositories, as well as the required dosage, should be selected individually by the attending physician, taking into account the nature of the disease, its duration and severity.
"Galavit" with a dosage of 50 mg is intended for use in children aged 6-12 years:
- In order to increase physical performance, take 1 rectal suppository every other day. Duration - 5 pcs.
- Therapy of peptic ulcer of the duodenum and stomach during the period of exacerbation involves the use of “Galavit” in the amount of two suppositories once a day for the first two days, and subsequently every three days for one candle. The course of therapy includes the use of up to 25 rectal suppositories. The chronic period of the disease - one suppository once 5 days, followed by 1 rectal suppository per day every three days. The duration of therapy is 20 pcs.
- For the treatment of infectious bowel diseases accompanied by diarrhea, two suppositories should be used once, and then one suppository each. twice a day until symptoms are stopped. The course can be continued using one supper. every three days. The course of therapy is 20 rectal suppositories.
- Chronic herpes diseases suggest 5 days to use one supper. per day, then every other day - 1 rectal suppository. Course - 15 rectal suppositories.
- The initial dosage for viral hepatitis is once two supp., Then twice a day, one supp. until the moment intoxication and inflammation are stopped. Continue the course until 20 suppositories are used, one every three days.
- Therapy for diseases associated with HPV involves the use of one suppository. 5 days, then 1 rectal suppository every other day. Duration - 15 supp.
- For the treatment of stenic conditions, somatoform and neurotic disorders, one pc is prescribed. within five days, in the subsequent - on 1 rectal suppository every other day. Duration of admission - 15 pcs.
- For surgical diseases of a purulent nature, including burn injuries, chronic osteomyelitis, recurrent furunculosis, gangrenous appendicitis, purulent pleurisy, it is assumed to take one supp. 5 days, in the next 10 days every other day - one supper.
- In the treatment of periodontal diseases and oral mucous membranes, Galavit is recommended, one supper each. for five days, then one supp. every three days. The course of therapy involves taking 15 pcs.
- Prevention and treatment of urogenital infections with bacterial and viral etymology involves the use of one suppository twice a day, followed by 1 rectal suppository every other day. The course of treatment, depending on the severity of the disease, may include taking 10-15 rectal suppositories.
- Therapy and prevention of preoperative and postoperative surgical complications involves the administration of one supp. For five days, then after the operation, one supp. every other day, then - one supper. every three days. The course includes the use of 20 sections.
- Therapy of frequent diseases of ENT organs with viral and bacterial etymology, for example, frequent acute respiratory viral infections, bronchitis, pneumonia, chronic tonsillitis, chronic otitis media, chronic adenitis, involves the use of one supper. for five days, and subsequently for ten days - one rectal suppository every other day.
- For the prevention of acute respiratory viral infections, one suppository should be used within five days.
"Galavit" with a dosage of 100 mg is intended for use in adolescents over 12 years old, in adult patients:
- In order to improve performance, it is recommended that every other day one supp., Then every three days, one supp. The course is 15-20 rectal suppositories.
- With erysipelas, chronic furunculosis - 5 days, 1 rectal suppository, and then every other day - one supper. Course - 20 rectal suppositories.
- An acute period of duodenal ulcer and stomach ulcer: during the first two days, 2 supp., And then every three days, 1 rectal suppository. The course is 15-25 rectal suppositories. Chronic period - the first five days, 1 supp., Then every three days, 1 rectal suppository. Course - 20 rectal suppositories.
- Intestinal infections with diarrhea syndrome in the acute period - once 2 pcs., Then twice a day for 1 supp. Until the symptoms disappear. The course of treatment can be continued using every three days for 1 rectal suppository. The course is 20-25 candles.
- Viral hepatitis - once 2 suppositories, then twice a day - 1 supp. Before stopping symptoms. The course can be continued using 1 supp. every three days.
- HPV - the first 5 days for 1 rectal suppository, and then every other day - 1 suppository. Course - 20 rectal suppositories.
- Relapsing herpes diseases - the first five days, 1 suppository, then every other day - 1 suppository. Course - 15 pcs.
- Salpingoophoritis, acute period of endometritis - during the first two days, once a day for 2 supp., Then every three days - 1 rectal suppository. Chronic period - the first five days, 1 rectal suppository once, then every three days - 1 supper. Duration - 20 supp.
- Acute purulent diseases affecting the pelvic organs - once 2 supp., Then for 3 days, 1 supp., Then every other day 1 supp. Course - 10 supp. The chronic period - the first five days, 1 supper, then every three days - 1 candle.
- Rehabilitation after surgery for resection of uterine fibroids - 5 days for 1 rectal suppository, then every other day - 1 rectal suppository. Course - 15 supp.
- Prevention and treatment of surgical complications - the first five days once in a dose of 1 supp, after the operation - every other day in a dose of 1 supp. for 10 days, then every three days - 1 supp. Course - 20 supp.
- Asthenic conditions, somatoform and neurotic disorders, behavioral, mental, post-withdrawal disorders against alcohol or drug addiction - 5 days for 1 rectal suppository, then every three days - 1 supp. Course - 15-20 pieces.
- Periodontal disease, inflammation of the mucous membranes of the throat and mouth - 5 days for 1 rectal suppository, then every three days for 1 pc. Duration - 15 supp.
- Urogenital infections, including chlamydial urethritis and prostatitis, Trichomonas urethritis - twice 1 supp. on the first day, then every other day, 1 rectal suppository. Course - up to 15 pcs.
This confirms the instructions for use for the Galavit candles.
Side effects
“Galavit” very rarely provokes the occurrence of side effects, in about 0.1% of cases. If these happen, they are manifested in the form of allergic reactions of the skin and mucous membranes - urticaria, rash, redness, itching. If there is any side effect due to the use of Galavit, you should immediately contact your doctor.
There are currently no data on overdose of Galavit suppositories. Nevertheless, the recommended dosage should not be exceeded in order to avoid the development of side effects.
Let us consider in more detail the instructions for the Galavit candles in gynecology.
Gynecology
This medication is often used in complex therapy:
- exacerbations of genital herpes;
- urogenital diseases in which nonspecific, trichomonas, as well as chlamydial etiology;
- purulent or inflammatory lesions in the pelvis;
- after gynecological surgery to prevent complications and speedy recovery.
Interaction with other medicines
Parallel therapy with drugs that have an antibacterial effect, reduces the dosage of the latter.
During the course of Galavit therapy, the use of alcoholic beverages is not prohibited, but do not abuse them. So it is told in the instruction for application to the Galavit candles.
Other interactions of “Galavita” with other medicines are not currently registered.
Analogs
At the moment, “Galavit” has no analogues in the active component. If there is a need, then it is possible to replace the Galavit suppositories with a different pharmacological form of the same drug. Galavit is also produced by the manufacturer in the form of injectable solutions and tablets. It is important to remember that replacing with Galavit suppositories should be done only after consulting a doctor.
There are drugs that have a similar therapeutic effect. Among them: Cycloferon, Lavomax, Amiksin, Anaferon, Immunoflazid, Groprinosin, Immunomax, Echinacea Forte, Immunal, Immunofan, Wobenzym, Ribomunil ”,“ Imudon ”,“ Cordyceps ”,“ Timalin ”,“ Sellsept ”,“ IRS 19 ”,“ Ekhinokor ”,“ Estifan ”,“ Ergoferon ”,“ Flogenzim ”,“ Exalb ”,“ Timusamine ”,“ Tubosan ”,“ Timogen ”,“ Taktevin ”,“ Splenin ”,“ Ruzam ”,“ Profetal ”,“ Neovastet ”,“ Mielopid ”,“ Imiquimod ”,“ Deoxinat ”,“ Gepon ”,“ Bestim ”,“ Arpeflu ”, "Tamerit."
Many people need to choose an analogue cheaper than Galavit candles. "Estifan" today is considered one of the most beneficial substitutes for the drug we describe. He has the same pharmaceutical group, but as part of it contains a different active substance (estifan 200 mg).
How much and how is it stored?
Galavit in the form of candles is recommended to be stored at a temperature of less than 12 degrees Celsius. Suppositories, subject to storage conditions, retain their therapeutic properties for 2 years. It is strictly forbidden to use the medication after its expiration date has expired.
The cost of "Galavita"
The average retail price of Galavit in the form of suppositories is at the level of 850-950 rubles per package. It contains 10 suppositories.
Reviews of candles "Galavit"
In gynecology, they are used very often.
On the network there are very diverse reviews about "Galavit" in the form of suppositories. Many patients attending drug forums are often unable to formulate a clear opinion. For the most part, this is due to the fact that Galavit suppositories are used in most cases during complex therapy. Therefore, it is impossible to assert with full confidence that the necessary effect in the treatment was achieved thanks to this particular drug.
However, other patients report that this particular drug contributed to their faster and more effective treatment.
Doctors, in turn, are also ambiguous about the use of Galavit suppositories in gynecology. Some argue that the drug is a very effective immunomodulator that allows you to activate the functioning of the immune system. Others are skeptical of the drug. This is due to the fact that each patient is unique, and therapy for him should be selected individually, taking into account all the characteristics of the body. That is, Galavit can be highly effective for one patient and at the same time ineffective for another.
A distinctive feature of Galavit is that it completely lacks side effects, which patients who used it are pleased to note. Be that as it may, when choosing an immunomodulator should not rely on reviews on the Internet. The drug should be prescribed only by a competent specialist who will take into account all the nuances of the patient's history, especially his body and the course of the disease.
We examined the Galavit candles for instructions on the use in gynecology and not only.