The solution "Heptral" refers to hepatoprotectors with antidepressant properties. The main component of the drug is neuroprotective, restoring and antioxidant quality. The drug makes up for the deficiency of ademetionine and stimulates its natural production by the body, in particular, in the brain and liver.
The drug can be taken only after prior consultation with the treating doctor to prevent the occurrence of side effects and dangerous complications.
Features of the drug
Heptral solution refers to hepatoprotective drugs and has a complex effect. It has cholekinetic and choleretic quality. Increases the level of glutamine in the liver, as well as taurine and cysteine ​​in plasma, improving metabolic processes.
The drug has a choleretic effect, which is due to the mobility of the membranes of hepatocytes, due to the stimulation of the production of phosphatidylcholine. This allows you to normalize the functioning of bile acids and promotes their penetration into the biliary system.
In patients with liver diseases, in particular, with cholestasis, the severity of itching of the skin and changes in blood counts, including direct bilirubin, are reduced. The therapeutic effect persists for 3 months after the end of treatment.
Quite good performance is observed with hepatopathies arising from the use of drugs that have a toxic effect on the liver. The antidepressant activity of the drug does not appear immediately, but only starting from the end of the first week of therapy and stabilizes over 2 weeks. This tool has the ability to eliminate relapses of depression.
It is prescribed for osteoarthritis and reduces the severity of pain, leads to partial restoration of damaged cartilage tissue, and also increases the production of prostate glycans.
After administration of the drug, the maximum concentration of active components in the plasma is reached after about 2-6 hours. The bioavailability after injection is 95%. The highest concentration is noted in the spinal cord, and excreted by the kidneys. The half-life is approximately 1.5 hours.
Release form and composition
The drug "Heptral" is available in the form of tablets for oral administration, as well as a solution for intravenous and intramuscular administration. In 1 bottle of the drug contains 400 mg of ademetionine ion. The kit also comes with a solvent, which includes sodium hydroxide, water for injection, as well as L-lysine.
The solvent is a clear, clear liquid. It can be light yellow or unpainted. The concentrate is packaged in bottles of unpainted glass in 5 ml, solvent - 5 ml in ampoules. Both of these drugs are embedded in small cells of 5 pcs. The box contains 5 bottles and ampoules.
The principle of the drug
Heptral solution contributes to the provision of antidepressant, choleretic, antioxidant, neuroprotective effects. When using the drug, the process of purification from toxins and bile acids is enhanced. The drug improves the functioning of the gallbladder, has a hepatoprotective and choleretic effect, which persists for 12 weeks after cessation of its use.
The drug is effective in the treatment of acute depression and also helps in preventing relapse. It is effective in neurological and endogenous depressive states.
Long-term use of the drug "Heptral" increases the level of taurine and cysteine ​​in blood plasma, as well as glutamine. It normalizes metabolic processes in the liver, and also significantly improves the functioning of this organ.
In the course of the research, it was revealed that the medicinal composition has a good result in the treatment of depressive disorders. With regular use of the drug "Heptral" there is a pronounced antidepressant effect. The maximum result is noted after 5-7 days from the start of the drug.
Indications for use
According to the instructions for use, the Heptral solution is indicated for such conditions as:
- intrahepatic cholestasis;
- fatty liver disease;
- cholangitis;
- chronic hepatitis;
- toxicological damage to the liver;
- cirrhosis of the liver;
- cholecystitis;
- encephalopathy.
In addition, a medication is prescribed for symptoms of depression, as well as intrahepatic cholestasis in pregnant women.
Features of the use of the medicinal composition
Heptral solution is used for intravenous or intramuscular administration. For this, just before injection, you need to mix the contents of the vial of the drug with 1 ampoule of solvent. The finished product should be transparent with a yellowish tint without sediment. After filling in the required amount of solution in the syringe, the residue must be disposed of. As stated in the instructions, the solution "Heptral" with intravenous administration is administered very slowly. The daily dosage of Heptral is selected separately for each patient.
At the initial stage, the introduction of 5-12 mg of the drug per 1 kg of human weight is required. With intrahepatic cholestasis and depression - 400-800 mg. The course of therapy lasts 2 weeks. In the treatment of depression, therapy is carried out for 2-3 weeks.
If necessary, treatment can be continued with the drug in tablets. The dosage of maintenance therapy should not exceed 4 tablets daily for 2-4 weeks.
The drug "Heptral" can be used not only to combat liver diseases, but also to treat depression. For this, the dosage is 400-800 mg daily, that is, 1-2 bottles, which are divided into 1-2 doses.
It should be borne in mind that one of the clinical signs of cirrhosis is a state of depression, apathy and tearfulness. The treatment period is 15-20 days. If necessary, the course of therapy can be 4 weeks, but the solution is replaced with tablets.
Many are interested in how to prepare the Heptral solution and apply it correctly. The medicine is prepared immediately before use. Leaving a drug is undesirable, as it can lose its healing properties. Droppers are placed for 1-2 hours and at the same time you need to monitor the patient's well-being all the time to prevent the occurrence of side effects.
According to the instructions, the Heptral injection solution can be used as injections. To do this, remove the aluminum cap, open the medicine and solvent, cutting off the top of the ampoule and mix them until the required dosage is reached. It is important that the drug does not have undissolved particles and acquire a white or slightly yellowish tint. If the solution has impregnated impurities or the powder has not dissolved, it is strictly forbidden to use it.
After preparing the medication, the resulting composition should be drawn with a syringe. Disinfect the injection site with alcohol, inject intramuscularly into the upper part of the buttock or the outer part of the shoulder. In addition, you can use the drug for intravenous administration. It is advisable to entrust this procedure to a qualified specialist. After removing the needle, wipe the injection site again with alcohol. To prevent the formation of bruises and abscesses, the drug is recommended to be administered slowly, constantly departing from the previous puncture site by 1 cm.
Contraindications
The instruction of the Heptral solution suggests that this medicine has certain contraindications. These include such as:
- hypersensitivity to the components of the drug;
- pregnancy in 1-2 trimester;
- age up to 18 years;
- breast-feeding.
In addition, according to the instructions for use of the Heptral solution, it is strictly forbidden to use it for the treatment of people with genetic disorders of enzymes. With extreme caution, it is necessary to carry out therapy with the simultaneous administration of antidepressants, as well as drugs containing herbs.
Side effects
According to the instructions, the Heptral injection solution can provoke the occurrence of certain side effects. These include the following:
- muscle cramps and joints;
- abdominal pain, nausea, dry mouth;
- a change in the work of the heart and blood vessels;
- dizziness, sleep disturbance, severe anxiety;
- the development of infectious diseases;
- laryngeal edema.
At the injection site, itching and urticaria may occur. Tissue necrosis is also possible. In especially severe cases, anaphylactic shock is possible. This is a very dangerous condition, which is characterized by pain in the back and behind the sternum, pressure drops, narrowing of the bronchi.
Overdose
In case of an overdose of the Heptral injection solution or its prolonged and uncontrolled use, the patient may show signs of an overdose, which is characterized by an increase in adverse events.
The antidote for this drug does not exist. In case of an overdose, a person needs to take enterosorbents and consult a doctor regarding subsequent treatment.
special instructions
According to the instructions for use, the Heptral injection solution has its own rules of use, which must be taken into account. When treating with a drug, it should be borne in mind that it contains 23 mg of sodium per dosage. It is recommended to introduce the finished product very slowly.
If a lack of vitamin PP occurs in the patient’s body, a decrease in the amount of ademetionine in the blood may be observed. For this reason, doctors recommend regularly taking a general blood test, as well as checking the level of substances important for the body. The risk group also includes people with:
- liver diseases
- anemia
- during pregnancy.
In addition, this applies to people who adhere to the vegetarian system for a long time. If, according to the results of the analyzes, a deficiency of vitamins is found, then during the treatment period they need to be taken additionally.
There are many remedies and treatments for depression. Only the attending doctor can choose the most correct and adequate therapy, which will show maximum effectiveness. Patients must necessarily inform the doctor about the deterioration or improvement of well-being during the course of treatment.
Many people note a feeling of anxiety when taking Heptral. In this case, drug withdrawal is completely optional, since it is enough to adjust the dosage, and this symptom will cease to bother.
The main component of the drug is able to influence the results of immunological analysis and shows a false value. For this reason, non-immunological research methods are recommended for determining homocysteine ​​parameters.
Since the data of ongoing clinical studies indicate a restriction of the use of Heptral solution in patients with impaired renal function, they should be treated under strict medical supervision.
In the reference book of medicines or radar, the Heptral solution refers to hepatoprotectors with antidepressant effects. However, in some cases, it, on the contrary, provokes the onset of depression, which is accompanied by the appearance of thoughts of suicide. Such a depressive state may persist until the onset of a period of remission, which occurs approximately 7-14 days after the start of therapy. For this reason, patients should be monitored by relatives or health care providers.
Other diseases related to the psyche are no exception. They can also trigger the development of depression and require special attention to the patient.
The prescription of the Heptral drug in late pregnancy does not provoke any negative manifestations to either the fetus or the mother. In the first and second trimester of bearing a child, this drug can be used only according to the strict prescription of the doctor, after the ratio of all risks to the life and health of the unborn child.
If there is a need for Heptral treatment during breastfeeding, it is recommended to abandon lactation at this time.
Sometimes during the course of therapy, patients note dizziness. In this regard, doctors do not recommend the patient to drive a car or other complex mechanisms that require increased attention until the end of therapy or until the unpleasant symptoms disappear.
Doctors say that there is no difference in the treatment of elderly and young patients. To prevent the occurrence of negative manifestations, therapy should be started with a minimum dosage, and at the same time, the functioning of the kidneys, liver, and cardiac activity are taken into account. There is no reliable data on the safety of the use of Heptral in childhood.
Given the tonic qualities of this drug, it is not recommended to use it immediately before bedtime. It is also important to regularly undergo examination by a specialist in order to monitor the therapy process and, if necessary, make the necessary adjustments to achieve the best result.
The shelf life of the drug is 3 years. The final date of use is indicated on the cardboard packaging. After its completion, the use of the medicine is strictly prohibited. Heptral vials require strict adherence to the temperature conditions specified in the instructions and storage out of the reach of children. You can buy the drug only by prescription.
Drug interaction
Basically, Heptral 400 mg solution is used for treatment, which goes well with many medications. In addition, the drug significantly reduces the negative effects of other drugs on liver cells and reduces the risk of side effects during general therapy.
With extreme caution, heptral solution is prescribed to people who are already taking psychotropic substances or antidepressants.
Analogues of the drug
Many patients are interested in what is better than Heptral, since for some reason this medicine may be contraindicated for them. That is why it is important to choose the right analogues. Among the most popular drugs you need to highlight such as:
- Heptor;
- "Essential";
- "Phosphogliv";
- "Carsil."
Before using analogues, it is necessary to consult a doctor regarding the availability of indications and contraindications to prevent deterioration of well-being.
Heptral analogue of the Heptor tablets has good reviews. They are identical in their action, as they help restore and protect liver cells, and also help get rid of depression.
The drug "Heptrong" normalizes liver function, reduces the intensity of the course of inflammation and reduces the pathological activity provoked by hepatitis. Available in the form of ampoules for intramuscular administration.
The drug "Phosphogliv" is considered a good hepatoprotector made from natural plant materials. This medicine helps eliminate the unpleasant symptoms associated with impaired liver function. The drug acts especially well as maintenance therapy in the treatment of hepatitis C.
The drug "Hepadif" is a combination drug. It is prescribed for liver intoxication, fatty degeneration of this organ, cirrhosis, acute and chronic hepatitis.
The drug “Karsil Forte” has indications similar to Heptral. These include rehabilitation after acute hepatitis, as well as liver damage. It has a good result in the fight against cirrhosis and steatosis.
The medicine “Glutargin” normalizes the functioning of the liver, helps with intoxication and poisoning with toxic substances, is effective in treating alcohol intoxication of mild and moderate severity, and also helps to cope with a hangover.
The drug "Hepa-Merz" is used to restore normal liver function, as well as the treatment of viral, autoimmune, metabolic diseases. It is available in powder bags, which must be diluted with water and ampoules for intravenous administration.
A very good analogue is considered to be the "Fosfoncial". It is prescribed for fatty liver disease, which was triggered by various factors, including chronic infection and diabetes. This analogue helps well with hepatitis and cirrhosis, copes with intoxication after poisoning. Also, the drug is prescribed as an adjunct therapy for psoriasis.
Reviews
When using the Heptral drug, the instructions and reviews of doctors and patients must be studied.Some say that after the use of the medicinal composition, health is normalized, and blood counts are improved, which is clearly seen in clinical trials. Despite the fact that the drug is quite expensive, it is very effective, as it quickly improves the liver condition.
Heptral tablets, reviews from patients mostly earned positive, after their use, health, quickly improves, mood improves, weakness passes, appetite increases. The result can be seen after the first course of taking the drug.
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The drug "Heptral" is widely used to treat liver diseases, even very complex ones, and is also used as part of prophylaxis.