"Neuromidine" is a drug that acts on smooth muscles, increasing its contractile properties and normalizing the functioning of the nervous system. In addition, this medicine leads to a stable state of contacts between muscles and nerves, helps to improve the quality of memory and stops the progression of pathologies due to impaired cognitive functions.
The drug is prescribed during the recovery period after a stroke in the brain, with lesions of the roots of the spinal cord, muscle weakness, impaired motor activity, as well as in pathological processes or in the absence of peristalsis of the gastrointestinal tract.
In the article, we consider the instructions for "Neuromidinum" and patient reviews about this drug. We also provide information about analogues of this medical product.
Structure
According to the instructions, "Neuromidine" is produced in several forms:
1. A solution intended for subcutaneous or intramuscular injection. It is a clear and colorless liquid in ampoules. One package contains 10 ampoules of 1 ml.
2. Tablets for oral administration. White, 50 pcs. in one package.
According to the instructions for use for injections of Neuromidin, the composition of the solution for injection includes ipidacrine hydrochloride as an active substance, as well as water for injection and hydrochloric acid as an auxiliary component.
The tablets contain the same active ingredient as the solution, however the additional components are different. This is potato starch, calcium stearate, lactose.
The properties
In accordance with the instructions, "Neuromidine" is an anticholinesterase agent that has a stimulating effect on the transmission of neuromuscular impulses and enhances the degree of contractility of smooth muscles. The active component of the drug helps to normalize the conductivity of nerve impulses sent by the nervous system on the periphery, and also boosts the central nervous system.
The drug has the following properties: analgesic and antiarrhythmic effect, increased ability to memorize and learn. The tool practically does not have a systemic effect on the body, therefore it has no toxic, carcinogenic, teratogenic and mutagenic properties. The active components of the drug are rapidly absorbed and reach a maximum concentration in the blood one hour after administration.
Tablet indications
As the instruction informs us, "Neuromidine" in tablet form is prescribed for the following diseases and conditions:
1. Cognitive impairment.
2. Disorders of the vestibular type.
3. The period of rehabilitation after damage to the central nervous system of the organic type, when there are impaired motor function.
4. Intestinal atony of various origins.
5. Diseases of the nervous system on the periphery.
6. Polyradiculopathy and polyneuropathy.
7. Myasthenic syndrome and myasthenia gravis.
8. Paresis and paralysis of the bulbar type.
9. The lag of the child on physical and mental indicators.
Indications for injection
The drug in this form is prescribed for the same symptoms as the tablets. In addition, it is used in the following conditions:
1. Mononeuropathy.
2. Weak development of labor.
3. Disturbances in the central nervous system.
Thus, the drug eliminates some problems of the nervous system, as well as improve memory.
The instruction to "Neuromidinum" is very detailed.
Contraindications
The drug is not prescribed for the following diseases and conditions:
- Bradycardia
- The period of breastfeeding.
- Gestational period.
- Epilepsy.
- Bronchial asthma.
- Children under 18 years old.
- Gastrointestinal ulcer during exacerbation.
- Angina pectoris.
- Obstruction of the intestines and urinary tract.
- Violation of the functioning of the vestibular apparatus.
- Hypersensitivity to the components that make up the drug.
- Pathologies of the antipsychotic extrapyramidal type.
This is confirmed by the instructions for use of "Neuromidine".
Special conditions
With caution, the drug is taken for hypothyroidism, diseases of the respiratory system and lactose intolerance (in case of taking the drug orally).
The ban on taking the drug during pregnancy is due to the fact that the active component is able to provoke an increase in uterine tone. The restriction on the use of the drug in the lactation period is due to the fact that ipidacrine is able to pass into breast milk.
Instructions for use "Neuromidine"
According to the instructions for use, the dosage and duration of treatment should be determined by the doctor, who must take into account the severity of the disease and the individual characteristics of the patient. However, there is a standard therapeutic regimen.
For pathologies of the peripheral nervous system, the following dosages are used:
1. Polyneuropathy and polyradiculopathy of various origins suggest taking 0.5-1 tablets up to three times a day. Treatment should last at least one month. A second course of admission can be carried out after a break of several months.
2. Myasthenic crises, disorders of neuromuscular conduction are treated by injection of the drug in 1-2 ml. instruction
As indicated by the instructions for "Neuromidine", injections of this drug should be given in a short course, after which the transition to the tablet form is carried out. The multiplicity of taking the tablets increases up to five times a day.
Instructions for tablets "Neuromidine" must be strictly observed.
Dosing schedule
For pathologies of the central nervous system, the following dosage scheme is used:
1. Paresis and bulbar paralysis, as well as in the rehabilitation period after damage to the central nervous system of the organic type caused by injuries or disorders in the functioning of blood vessels, are treated by taking 0.5-1 tablets up to three times a day. The duration of admission is one to two weeks.
2. With intestinal atony, as well as for preventive purposes, 1 tablet is taken 2-3 times a day. The course and its duration are prescribed by the doctor.
The maximum daily dose should not exceed 200 mg. ipidacrine. You can not increase the dosage when skipping one tablet, you should strictly follow the doctor’s prescriptions and the instructions contained in the instructions.
Adverse Reactions and Overdose
According to the instructions for use and reviews, "Neuromidine" is able to cause unwanted reactions caused by activation of m-cholinergic receptors. This condition is accompanied by the following symptoms:
1. Enhanced secretion of the bronchi.
2. Diarrhea.
3. Bradycardia.
4. Heartbeat.
5. Convulsive syndrome.
6. Increased salivation.
7. Jaundice syndrome.
8. Increased sweating.
9. Soreness in the abdomen.
If the drug is prescribed in higher dosages, this may be accompanied by such adverse reactions: vomiting, headache, drowsiness, allergic reaction, weakness, pain in the sternum, dizziness.
Against the background of taking a high amount of “Neuromidin”, not only side effects, but also some complications may occur. So, an overdose of drugs can lead to a decrease in appetite, accelerate intestinal motility, excessive urination and diarrhea.
Exceeding the dosage several times can lead to such serious complications: violation of the heart muscle, arrhythmia, loss of coordination, confusion, convulsive syndrome. In especially severe cases, the patient may fall into a coma. In case of an overdose of Neuromidinum, symptomatic treatment is performed. The most commonly prescribed are Metacin or Atropine.
Special recommendations
Alcohol intake during treatment with Neuromidine is strictly prohibited. Ethanol is able to aggravate adverse reactions to the drug. You should also refrain from performing dangerous or requiring special concentration of work, as well as from driving vehicles. This is due to the fact that the drug negatively affects the speed of psychomotor reactions.
Drug interaction
It should be taken into account the compatibility of Neuromidin with other drugs, namely:
1. The drug may be prescribed in combination with drugs of the nootropic series.
2. The sedative effect of drugs that depress the nervous system is enhanced by the effects of ipidacrine.
3. The risk of bradycardia increases if beta-blockers were taken before treatment with the drug.
4. In combination with cholinesterase inhibitors and m-cholinomimetic drugs, the effectiveness of Neuromidin is enhanced, and adverse reactions to it may be aggravated.
5. With myasthenia gravis increases the likelihood of a cholinergic crisis.
6. Ipidacrine reduces the detrimental effect on the neuromuscular transmission of aminoglycosides, local anesthetics and potassium chloride.
Analogs
Similar drugs are those that have identical active components, as well as those that have the same therapeutic effect. The most common analogues of Neuromidin are considered Axamon and Amiridin.
We will not consider the instructions for analogues of "Neuromidine" in detail.
Indications for taking "Axamon" are almost identical to "Neuromidine." It is used for polyneuritis and polyradiculopathies, Alzheimer's disease and myasthenia gravis. In addition, the drug is prescribed when a woman has a weak labor activity. "Axamon" should not be given to children under 18 years of age. The dosage of the drug is prescribed taking into account the nature of the disease and its severity, but cannot exceed 200 mg of the active substance per day. Adverse reactions and signs of overdose are also similar to "Neuromidinum".
Amiridine is also virtually identical to the original drug. However, it can be prescribed not only for organic, but also for functional disorders of the nervous system. Such disorders are accompanied by a decrease in memory and ability to concentrate, disorientation and lability of emotions. In addition, Amiridin is prescribed for encephalopathy of traumatic or vascular origin, in case of impaired blood circulation of the brain after receiving an injury, as well as for cerebral dysfunction, which proceeds against the background of a decrease in children's learning ability.
This is noted in the instructions for use with the analogue of "Neuromidine".
Any similar drug can be used only after consulting a doctor, since even a similar drug may have its own characteristics of taking and contraindications.
Reviews
The comments of those who took "Neuromidine" are quite diverse. Reviews range from enthusiastic to sharply negative. Many who took the drug to eliminate myasthenia gravis were unsatisfied, since Neuromidin did not have any therapeutic effect.
There are many reviews of people who have undergone one course of treatment with the drug or are taking it on a regular basis. Some reviews say that there was no effect after the course of treatment, and after the drug was discontinued, no deterioration was noted. Parents of children born with a genetic pathology accompanied by muscle weakness also express the opinion that the drug is ineffective. But the drug is not allowed to be used to treat children, so the pediatrician is at risk by prescribing it.
There are also positive reviews. They talk about improving memory and the ability to learn and analyze. A similar effect is achieved a few days after the start of taking the pills. It is noted that the drug affects the heart, therefore, indicators of this organ should be monitored. Injections also gained a lot of positive feedback, especially from those who have problems with the gastrointestinal tract.
Experts emphasize that the medication is not a panacea for all diseases of the nervous system. Any treatment should use an integrated approach.
We reviewed the medication "Neuromidine" instructions, analogues and reviews.