The drug "Doxazosin", the price of which is from 80 rubles, has hypotensive, vasodilating activity, has an antispasmodic, lipid-lowering effect. Due to a decrease in muscle tone of blood vessels, blood pressure and overall peripheral vascular resistance decrease. Under the influence of the drug, there is a decrease in the level of HDL, total cholesterol, triglycerides, suppression of platelet aggregation and an increase in the concentration of active plasminogen in the tissues. Means "Dexazosin" (instructions for use confirms this information) helps to reduce pressure and resistance in the urethra, in the internal sphincter. After administration, the medicine is absorbed quite well. The absorption of the drug is 80-90%. When you eat, absorption slows down for an hour. The maximum concentration is reached after three hours, with evening reception - after five hours. The bioavailability of the drug is 60-70%. Metabolism occurs quite quickly in the liver cells. The drug is excreted in unchanged form with urine and in the form of metabolites through the intestine.
The drug "Doxazosin." Instructions for use. Appointment
The drug is recommended for arterial hypertension as an additional tool or as a single drug. As part of the combined treatment, the medication is prescribed with beta-blockers, thiazide diuretics, ACE inhibitors and others. Indications include benign prostatic hyperplasia (against a background of normal or high blood pressure).
Contraindications
The drug "Doxazosin" (instructions for use warns about this) is not prescribed at the age of eighteen years, during lactation, with hypersensitivity, in the antenatal period.
Adverse reactions
During therapy (especially in its initial stages), orthostatic hypotension may occur , leading in some cases to fainting. To prevent this condition, it is recommended to avoid a sharp change in body position. The drug "Doxazosin" (instructions for use indicates this) can cause dizziness, dry mouth, rhinitis, headache, arrhythmia. Based on the intake, tachycardia, drowsiness, arthralgia, chest pain, cerebrovascular disorders are observed. The undesirable consequences of therapy include fatigue, allergic reactions, angina attacks, nausea, skin rash, urinary incontinence, nosebleeds, heart attack.
Dosage regimen
The drug "Doxazosin" instructions for use in hypertension recommends starting to take once in a dose of 1 mg (at bedtime). Subsequently, the amount of medication rises to 16 mg / day. After taking the drug, you should be in a supine position for at least six to eight hours to prevent the "first dose" syndrome. If the effect is insufficient, the dosage is increased after 1-2 weeks to 2 mg. With an interval of seven to fourteen days, the amount of the drug is increased by 2 mg. Treatment of prostatic hyperplasia is carried out in a dose of 2 to 4 mg per day. The maximum dosage is eight milligrams per day.