In the article, we will consider whether the use of Nolitsin is effective for cystitis.
It is a drug with an antibacterial effect, which is part of the group of fluoroquinolones. The drug is used in the field of urology and nephrology in order to conduct the treatment of various diseases of an infectious-inflammatory nature. "Nolicin" is active against staphylococci, Klebsiella, Escherichia coli, Chlamydia, Salmonella, enterobacteria, Neisseria, hemophilic and dysenteric sticks. However, anaerobic bacteria and streptococci are resistant to the drug. "Nolicin" with cystitis is prescribed very often.
Release form
The drug is in the form of tablets, each of which contains 400 mg of the active ingredient. Pills are packaged in blisters of 10 and 20 pieces in one package.
Structure
The active substance of the drug is norfloxacin. The excipients of Nolitsin include the following components:
- Povidone.
- Sodium carboxymethyl starch.
- Colloidal anhydrous silica.
- Purified water.
- Magnesium stearate.
- Microcrystalline cellulose.
Pills for cystitis "Nolitsin" are available in a shell, which includes:
- Talc.
- Hypromellose.
- Titanium dioxide.
- Propylene glycol.
- Dye E110.
The properties
The instruction "Nolitsin" with cystitis is very detailed.
It is an antimicrobial drug. The highest concentration of active substance occurs when taking the drug in the urine. The active component of norfloxacin is included in the quinolone group. It is active against aerobic gram-negative bacteria, including strains of certain gram-positive microorganisms. Norfloxacin inhibits the bacterial DNA gyrase enzyme at the cellular level, which leads to a halt in its production and death of the harmful microorganism. In addition, norfloxacin interacts with some DNA constituents at the moment of chain cleavage, thereby preventing supercoiling and disrupting DNA production.
It should be borne in mind that it is possible to develop cross-resistance between several quinolones.
Is the appointment of "Nolitsin" with cystitis justified?
Indications
The instructions say that the drug is prescribed in the treatment of pathologies of an infectious and inflammatory nature, the appearance of which is provoked by pathogens that are sensitive to norfloxacin. The drug is prescribed in the following cases:
- Gonorrhea of the lower urogenital organs, proceeding without complications.
- An acute or chronic form of the pathology of the kidneys and urinary tract of an infectious nature, namely urethritis, pyelonephritis, cystitis. "Nolicin" with these ailments helps pretty quickly.
- Gastroenteritis, expressed in the inflammatory process of the mucous membrane of the digestive system. These are bacterial diseases such as shigellosis and salmonellosis.
- Infectious diseases localized in the pelvic organs and genitals, such as bacterial-type prostatitis in chronic form, cervicitis, endometritis, orchitis, epididymitis, etc.
In addition, the drug is prescribed as a prophylaxis of diarrhea during travel, sepsis in patients suffering from agranulocytosis, a recurring form of urinary tract pathology of infectious origin.
Contraindications
Is it always possible to use "Nolitsin" for cystitis in women?
The drug is taken only in accordance with the doctor’s prescriptions, since self-treatment can lead to undesirable reactions from the body and worsen the patient's condition. Before you start taking the drug, you need to carefully read the instructions, as there are a number of restrictions for taking. "Nolitsin" is contraindicated in patients with diseases and conditions such as:
- Gestational period and with breastfeeding.
- Sensitivity of an allergic nature to the components of the drug or norfloxacin.
- Kidney or liver failure.
- The age is up to eighteen years due to the lack of clinical trials proving the safety of the drug for children.
How to take "Nolitsin" with cystitis, not everyone knows.
Caution must be exercised when taking the drug in the following situations:
- Circulatory disturbance of the brain.
- Epileptic state.
- Deposits on the walls of the vessels of the brain of an atherosclerotic nature.
- Intolerance to acetylsalicylic acid.
Instruction manual
The instruction contains information that "Nolitsin" with cystitis is taken on an empty stomach or at least one hour before and two hours after a meal. The tablet should be washed down with a sufficient amount of water.
The standard treatment regimen is taking 1 tablet twice a day. The duration of therapy depends on the nature of the disease and ranges from one week to 14 days. In some cases, treatment may be prolonged. Consider the dosage regimen for various diseases:
- Gonorrhea without complications - a single dose of 2-3 tablets or one tablet twice a day for three days to a week.
- Bacterial prostatitis in chronic form - one tablet twice a day, the duration of treatment is from a month to a half. Sometimes even more.
- Gastroenteritis of bacterial origin - one tablet twice a day for five days.
- Cystitis in acute form without complications - one tablet twice a day for up to five days.
- Prevention of sepsis in the treatment of neutropenia - one tablet twice a day for two months.
- Prevention of uncomplicated diseases of the urinary tract of infectious origin in a recurring form with frequent exacerbations - 200 mg once a day at night. It is taken up to six months to several years.
- Prevention of diarrhea - 400 mg a day before the planned trip, as well as during the trip and a few days after its completion, but no more than three weeks.
With renal dysfunction, if KK more than 20 ml / min. no dosage adjustment is required. If the QC values are below 20 ml / min., As well as hemodialysis patients, half the standard dosage of “Nolitsin” is prescribed twice a day or a full dose once.
Side effects
Unwanted reactions while taking "Nolitsin" can appear in various systems and organs:
- The hematopoietic system - leukopenia, hematocrit, eosinophilia.
- Cardiovascular system - arrhythmia, vasculitis, low blood pressure, tachycardia.
- The system of muscles and bones - arthralgia, tendon ruptures, tendonitis.
- An allergic reaction - swelling, itching, urticaria, Steven-Johnson syndrome.
- Nervous system - a condition of fainting, headache, sleep disturbance, dizziness, hallucinations. In elderly patients, a feeling of fear, irritability, fatigue, drowsiness, anxiety, depression, and tinnitus are also possible.
- Digestive system: loss of appetite, vomiting, nausea, pain in the abdomen, bitterness in the mouth, diarrhea, pseudomembranous enterocolitis, increased liver transaminase activity.
- Urinary system - albuminuria, glomerulonephritis, polyuria, crystalluria, dysuria, increased creatinine and urea in blood plasma, urethral bleeding.
- Others - candidiasis.
If the dosage prescribed by the doctor is exceeded, an overdose of Nolicin may occur, which manifests itself as follows:
- Drowsiness.
- Intense vomiting.
- Dizziness.
- Cold sweat.
When such signs appear, dehydration treatment should be carried out with gastric lavage and forced diuresis. An antidote for this drug has not yet been developed.
Special recommendations
Before taking "Nolitsin", you must carefully read the instructions for use. There are a number of special instructions, namely:
1. During the treatment with "Nolitsin" you need to avoid sunbathing, as well as strictly observe the drinking regime with the control of diuresis.
2. The drug should be replaced urgently if there are tendon pains or symptoms of tendovaginitis. When taking norfloxacin, intense physical activity must be avoided.
3. At the time of treatment, an increase in the prothrombin index is possible. If there is a need for surgical intervention, it is necessary to control the indicators of blood coagulation.
4. In case of intolerance to acetylsalicylic acid, the risk of developing an allergic reaction, which can lead to spasm of the bronchi, should be taken into account.
Interaction with other drugs
It is important to consider the interaction of norfloxacin with the active substances of other drugs:
1. The effect of taking nitrofurans when combined with norfloxacin is reduced.
2. With simultaneous administration with drugs that have an anticonvulsant effect, the development of epileptic seizures is possible. In combination with GCS, norfloxacin may increase the risk of tendon rupture or tendonitis. The effect of taking hypoglycemic drugs when combined with norfloxacin increases.
3. The therapeutic effect of cyclosporine and warfarin is enhanced while taking with norfloxacin. In some cases, this combination led to an increase in serum creatinine concentration.
4. Antacids, which include magnesium and aluminum hydroxide, as well as zinc, iron and sucralfate reduce the effect of norfloxacin. Between them there should be a break of at least two hours.
5. Norfloxacin and theophylline require constant monitoring of the concentration of the latter in blood plasma. Norfloxacin dosage adjustment may be required.
6. With the simultaneous administration of "Nolitsin" with drugs that have an antihypertensive effect, a sharp decrease in blood pressure may occur. Thus, the simultaneous use of norfloxacin with barbiturates and drugs for general anesthesia requires monitoring of the cardiovascular system.
Consider the reviews of "Nolitsin" with cystitis.
Reviews
According to reviews, this drug is very effective for cystitis. Symptoms of pathology are already on the third day of admission. Most often, it is well tolerated. But women still note some side effects - nausea, abdominal pain, the development of candidiasis. But if you follow the instructions for use, then such reactions of the body can be minimized.
Reviews of "Nolitsin" with cystitis in women, we reviewed.