Dosage form of the drug "Dexamethasone"
The instructions include abbreviated information on dosage forms. The drug is available in the form of eye drops, that is, a whitish suspension. Resuspendable sediment may be present.
Structure:
Active substance
- Dexamethasone - 1 mg (in 1 ml of suspension)
Excipients:
- Sodium chloride
- Dinarium phosphate dodecahydrate
- Hypromellose
- Polysorbate
- Citric Acid Monohydrate
- Benzalkonium chloride
- Disodium edetate dihydrate
- Purified water
In addition, the release of the drug in other dosage forms is possible.
Pharmacological action of the drug "Dexamethasone"
The instruction says that the medicine belongs to corticosteroids, while suppressing the functions of tissue macrophages and lymphocytes, which the drug also limits in its ability to migrate to the area of inflammation. The drug disrupts the possibility of macrophages to phagocytosis, and in addition the formation of interleukin 1.
It has a vasoectonic effect, being in close proximity to the vessels. Suppresses the uptake of glucose by fat cells, thereby activating lipolysis. But, due to an increase in the amount of insulin, lipogenesis is stimulated, which can lead to the accumulation of fat.
Indications for the use of the drug "Dexamethasone"
The use of the drug inside with the following diseases:
- Acute and subacute thyroid
- Addison-Birmer Disease
- Progressive ophthalmopathy (due to hypothyroidism)
- Hypothyroidism
- Rheumatoid arthritis
- Bronchial asthma
- Autoimmune Anemia
- Hypoplasia and aplasia in the blood
- Thrombocytopenia
- Congenital adrenogenital syndrome
- Serum sickness
- Agranulocytosis
- Pemphigus
- Acute erythroderma
- Malignant tumors
- Cerebral edema
For parenteral administration of the drug:
- Radiation damage to the brain
- Cerebral edema
- Encephalitis
- Brain hemorrhage
- Meningitis
- Asthmatic status
- Shock of various origins
- Dermatosis
- Bronchospasm
- Quincke's edema
- Acute Anaphylaxis for Medicines
- Pyrogenic reactions
- Serum transfusion
- Thrombocytopenia
- Hemolytic anemia
- Agranulocytosis
- Lymphoblastic leukemia
- Infectious diseases
- Spicy croup
- Adrenal cortex insufficiency
- Osteoarthrosis
- Arthritis
- Compression Neuropathy
- Tenovaginitis
- Bursitis
- Styloiditis
- Epicondylitis
- Periarthritis of the shoulder blade
For use in ophthalmology:
- Keratitis
- Conjunctivitis
- Irit
- Keratoconjunctivitis
- Blepharoconjunctivitis
- Iridocyclitis
- Episiscleritis
- Blepharitis
- Sclerite
- Sympathetic Ophthalmia
Side effects of the drug "Dexamethasone"
The instruction includes data on side effects regarding various body systems and other dosage forms of the drug "Dexamethasone" - tablets. The instruction is presented in shortened form.
Possible side effects from the use of the drug from the endocrine system:
- Itsenko-Cushing's Syndrome
- In children, delayed sexual development
- Diabetes
- Decreased glucose tolerance
- Inhibition of adrenal function
On the part of the body's metabolism:
- Hypocalcemia
- Excretion of calcium ions
- Negative Nitrogen Balance
- Hypernatremia
- Increased sweating
- Weight gain
- Hypokalemia
From the side of the central nervous system:
- Euphoria
- Disorientation
- Delirium
- Depression
- Manic-depressive syndrome
- Hallucinations
- Increased intracranial pressure
- Insomnia
- Nervousness
- Anxiety
- Vertigo
- Dizziness
- Cramps
- Headache
From the CCC:
- Bradycardia
- Arrhythmia
- Chronic heart failure
- Hypercoagulation
- Increase in blood pressure
- Thrombosis
From the gastrointestinal tract:
- Vomiting
- Nausea
- Stomach ulcer
- Erosive Esophagitis
- Gastrointestinal Perforation
- GI bleeding
- Impaired appetite
- Hiccups
- flatulence
Contraindications for the use of the drug "Dexamethasone"
The instruction does not include exhaustive data on the contraindications of the drug, for more detailed information, you should contact the official source. The main contraindication for administration is sensitivity to dexamethasone. In addition, contraindications associated with infectious diseases, inflammations, etc. are possible.