High blood pressure brings not only tangible discomfort to the patient, but also is life threatening. To normalize their condition, many people resort to folk remedies. However, experts note that raising low blood pressure at home is much easier than lowering high blood pressure. Therefore, they recommend the use of drugs specifically designed for these purposes.
One of the most popular and effective remedies for hypertension is a medication such as Bidop. Indications for use, analogues and consumer reviews of this drug will be discussed later. You will also learn about how to use this medicine correctly, whether it has side effects and contraindications.
Description, form of release, packaging and composition of the drug
The drug "Bidop", analogues of which are sold in all pharmacies, is available in the form of light brown tablets with yellowish inclusions and a film coating. They have a round, biconvex shape with the marking βB1β above the notch and the number β5β (β10β) below it.
The active ingredient of this tool is bisoprolol hemifumarate. As for auxiliary components, lactose monohydrate, magnesium stearate, microcrystalline cellulose, crospovidone and yellow pigment PB 22812 (13% yellow iron oxide and 87% lactose monohydrate) are used as them.
You can buy Bidop tablets, the use of which is mandatory for people with high blood pressure, in blisters and packs of cardboard, respectively.
Pharmacodynamic indicators of the drug
What is Bidop Medication? Indications for use of this drug are due to its pharmacological action. This drug is a selective Ξ²1-blocker. It does not have a sympathomimetic effect, and also does not have a membrane-stabilizing effect.
The drug in question can reduce renin activity, reduce myocardial oxygen demand and reduce its contractility.
"Bidop" is a drug that has antianginal, antiarrhythmic and hypotensive properties. Suppressing myocardial Ξ²1-adrenergic receptors (in small doses), it reduces the intracellular transport of calcium ions, reduces the synthesis of cAMP from ATP (stimulated by catecholamines), has a negative chrono-, batmo-, dromo- and inotropic effects, and also slows down the processes of conduction and excitability.
If therapeutic dosages are exceeded, the drug exhibits a Ξ²2-blocking effect.
At the very beginning of therapy (in the early days), the peripheral resistance of the vascular walls increases. After 3 days, it becomes close to the original, however, after prolonged treatment, it significantly decreases.
Drug properties
What properties are inherent in the medicine "Bidop"? The pharmacological effect of this drug is due to its composition.
The hypotensive effect of the drug is associated with a decrease in the minute volume of blood, sympathetic stimulation of the peripheral vascular walls, as well as a weakening of the renin-angiotensin system, the effect on the nervous system and the restoration of feedback, which comes in response to a decrease in pressure.
With hypertension, the therapeutic effect of the drug develops within five days. His confident action comes two months later.
What is the antianginal effect of this medicine? Description of the drug "Bidop" reports that such an action is caused by a decrease in myocardial tissue oxygen requirements. This happens by reducing the heart rate, reducing contractility, lengthening diastole and improving blood circulation. Due to the increase in diastolic pressure in the ventricles and the stretching of their muscle tissue, oxygen demand may increase.
As for the antiarrhythmic properties of the medication in question, it is due to the elimination of factors that cause arrhythmia (activation of the sympathetic system, tachycardia, arterial hypertension, increased concentration of cAMP). Also, this drug inhibits AV conduction and reduces the rate of arousal of pacemakers.
What other features are inherent in the medicine "Bidop"? Instructions for use, description, reviews of experts state that when taking medium therapeutic dosages, this tool, unlike indiscriminate Ξ²-blockers, affects organs that have Ξ²2-adrenergic receptors (pancreas, skeletal muscle, peripheral arterial muscles) much less pronounced , uterus and bronchi), as well as the exchange of carbohydrates. Moreover, the drug in question does not trap sodium ions, and the strength of its atherogenic effect is comparable to propranolol.
Kinetic parameters of the drug
What are the kinetic properties of the drug "Bidop"? Patient reviews will not answer this question. It is contained only in the instructions. According to her, after taking the medication, it is absorbed from the digestive tract by 80-90%. Eating does not affect this process.
The maximum concentration of the active component in the blood is recorded after 2-3 hours. This drug comes into contact with plasma proteins by 30-32%. It passes rather poorly through the blood-brain barrier and the placenta.
About 50% of the drug is transformed in the liver. In this case, almost inactive metabolites are formed.
The half-life of the drug reaches 12 hours. About 2% of the drug is excreted along with bile and about 98% through the kidneys.
Indications for use
"Bidop" is not only a hypotensive drug, but also an antianginal and antiarrhythmic drug. Thus, it is prescribed to eliminate arterial hypertension and to prevent attacks of exacerbation of stable angina pectoris.
Contraindications antihypertensive drugs
Now you know what a medicine like Bidop is for. Indications for use were presented above. However, the drug in question is strictly prohibited for:
- shocked;
- collapse;
- acute heart failure;
- pulmonary edema;
- sinoatrial blockade ;
- AV blockade of the second or third degree (without electrical stimulator);
- sick sinus syndrome;
- severe bradycardia;
- chronic decompensated heart failure, which requires inotropic therapy;
- Raynaud's disease ;
- arterial hypotension;
- metabolic acidosis ;
- concomitant use of MAO inhibitors (except for B-type MAO);
- cardiomegaly (without heart failure);
- bronchial asthma and severe COPD;
- changes in peripheral circulation, especially in the later stages;
- pheochromocytoma (without taking alpha-blockers);
- sensitization to drug substances or other beta-blockers;
- lactose intolerance, galactose / glucose malabsorption and lack of lactase;
- at a minor age.
Cautious appointment
Indications for the use of "Bidop" are listed in the attached instructions. It also says that with extreme caution, this drug is prescribed for diabetes mellitus, renal or hepatic insufficiency of a chronic type, myasthenia gravis, psoriasis, thyrotoxicosis, first-degree AV blockade, Prinzmetal angina pectoris, depression, an allergy in the anamnesis, a strict diet and for elderly people age.
Method of administration and dosage of medication
For what purpose is prescribed and how to use the drug "Bidop"? Indications for use, instructions for this medication are presented in this article.
Take oral tablets preferably in the morning, on an empty stomach. They can not be chewed, otherwise you will damage the film membrane.
The dosage of this tool is selected individually. To do this, be sure to consult a doctor.
So how should you take the drug "Bidop"? Indications for use, or rather, their presence - this is the most important condition for the appointment of this medication.
In order to prevent acute attacks of stable angina pectoris and in the presence of arterial hypertension, patients are given an initial dose of the drug equal to 5 mg. It is taken every day, once.
If required, the indicated amount is increased to 10 mg. In this case, the reception ratio is saved.
The maximum daily dosage of the drug "Bidop" is 20 mg.
In people with impaired renal function, as well as severe liver ailments, the highest dosage is 10 mg per day.
Correct the specified amount of medication to older persons is not required.
Unwanted effects
What adverse reactions can the Bidop medication cause? Patient reviews indicate the possible occurrence of certain unwanted effects. It:
- Dry eyes, blurred vision, decreased salivation, conjunctivitis.
- Orthostatic hypotension, AV block, a strong decrease in pressure, a decrease in myocardial contractility, sinus bradycardia, impaired myocardial tissue conduction, arrhythmia, the appearance of symptoms of heart failure (chronic), angiospasm, chest pain.
- Asthenia, weakness, fatigue, sleep disorders, confusion, myasthenia gravis, dizziness, nightmares, limb paresthesias, depression, anxiety, headaches, tremors, hallucinations, convulsions.
- Nasal congestion, difficulty breathing when taking the drug in high doses or in people with a predisposition to bronchospasm and laryngospasm.
- Nausea, hepatitis, dry oral mucous membranes, taste perversion, vomiting, liver dysfunction, constipation, hypertriglyceridemia, abdominal pain, diarrhea, hyperbilirubinemia, increased liver enzyme concentration.
- Exacerbation of psoriasis, psoriasis-like reactions, flushing of the skin, exanthema, increased sweating, alopecia.
- Hyperglycemia, hypothyroid state, hypoglycemia (in people who use insulin).
- Thrombocytopenia, agranulocytosis, leukopenia.
- Arthralgia, decreased potency, lumbalgia, weakening libido, thoracalgia, withdrawal syndrome.
- Urticaria, itching, rash.
- Bradycardia, intrauterine growth retardation.
Overdose symptoms
What side symptoms are observed when taking high doses of the drug "Bidop"? Indications for use of this tool are far from the only conditions for its use. It is very important to observe all dosages of the drug that have been recommended by your doctor. If this advice is neglected, then the patient may experience signs of an overdose such as bradycardia, ventricular extrasystole, hand cyanosis, arrhythmia, bronchospasm, AV block, dizziness, severe decrease in pressure, fainting, chronic heart failure, cramps, difficulty breathing and hypoglycemia.
To eliminate such conditions, the patient is washed the stomach, give enterosorbents and carry out symptomatic treatment.
Drug interaction
Is Bidop (drug) compatible with other products? What is this medicine used for, we found out. However, in combination with other medicines, it should be prescribed with extreme caution.
With the intravenous administration of the drug βPhenytoinβ, as well as when using funds for inhalation anesthesia, the cardiodepressive effect of βBidopaβ increases.
X-ray iodine-containing drugs for intravenous administration increase the risk of anaphylactic reactions.
Bidop often disguises signs of developing hypoglycemia. It also increases the concentration of xanthines and lidocaine in the blood.
Sympatholytics, diuretics, "Clonidine", "Nifedipine", "Hydralazine" and other antihypertensive drugs when combined with "Bidop" lead to a strong decrease in pressure.
Tetracyclic and tricyclic antidepressants, as well as ethanol, hypnotics, sedatives and antipsychotics increase CNS depression.
Special recommendations
What should a patient know before taking Bidop tablets? Reviews of doctors say that at the very beginning of treatment, patients must be careful and careful when driving.
Monitoring people who take the drug in question includes measuring your heart rate and pressure, as well as determining your blood sugar and conducting an ECG. Elderly people are required to monitor the functioning of the renal system.
Before starting treatment, it is necessary to diagnose respiratory function in patients with a burdened pulmonary history.
In the treatment of individuals with pheochromocytoma, there is a risk of developing paradoxical arterial hypertension.
In smokers, the effectiveness of beta-blockers is reduced.
If a planned surgical intervention is required, then the medication should be canceled two days before the implementation of general anesthesia.
With the development of depression, therapy must be stopped.
It is forbidden to abruptly interrupt treatment due to an increased risk of developing myocardial infarction or severe arrhythmias. The drug is canceled gradually, reducing the dose for two weeks or more.
Bidop tablets: analogues and cost
If necessary, the drug in question can be replaced by such means as Biskard, Aritel Cor, Tyrez, Aritel, Niperten, Bidop Cor, Cordinorm, Biprol, Coronal, Biol β,β Corbis β,β Bisogamma β,β Concor β,β Bisoprolol β,β Concor Kor β,β Bisomor β,β Bisoprolol-OBL β,β Bisoprolol-Teva β.
The cost of this antianginal, antiarrhythmic and antihypertensive drug is about 250-300 rubles (28 tablets).
Drug Reviews
Now you know why a medicine such as Bidop can be prescribed. Indications for use, consumer reviews about this medication are presented in the materials of this article.
Reports from patients indicate that the action of the drug in question is very effective. Bidop tablets quickly reduce blood pressure and significantly weaken all signs of coronary heart disease.
However, it should be noted that this drug very often causes side effects. They can occur on the part of any organs and systems.
It should be noted that for 20% of people with angina pectoris, this tool is ineffective. Doctors explain this by the presence of severe coronary atherosclerosis, as well as an increased diastolic volume of the left ventricle.
If there is no effect, the patient should consult a doctor to prescribe another therapy.