The patient is familiarized with the instructions to "Fromilid UNO" (500 mg) on the recommendation of a gastroenterologist, if during the examination revealed pathologies of a microbial nature. The tool belongs to the number of antibiotics. It shows maximum effectiveness as an element of complex treatment. "Fromilide UNO" is prescribed if infections caused by mycobacteria are detected. True, to independently prescribe a remedy for yourself even with an accurate diagnosis is categorically unacceptable. "Fromilide UNO" is used according to a special therapeutic scheme, combining with other specific drugs, otherwise, instead of improving, the patient will face a deterioration.
General view
As indicated in the instructions for use, "Fromilide UNO" is one of the antimicrobial substances of semisynthetic origin. The drug belongs to the category of macrolides. Once in the human body, the active compound inhibits protein synthesis in the cells of microscopic life forms. The tool has a pronounced bacteriostatic effect, bactericidal is slightly weaker. The main compound that provides the activity of “Fromilide UNO” is called clarithromycin.
In the instructions for the use of “Fromilide UNO” (the price of the drug is currently about 300 rubles) all the names of bacteria are listed, for which the medication shows effectiveness as an element of complex therapy. These life forms include gram-positive, gram-negative species. "Fromilide UNO" shows good results in the treatment of infection with some anaerobic microorganisms. But with respect to mycobacteria that provoke tuberculosis, the drug is not used - there will be no result.
What is going on in the body?
In the instructions “Fromilida UNO” (price - about 300 rubles) describes in detail what processes are observed in the patient’s body after taking the drug, after what time period it is worth waiting for an answer, what negative reactions may be. In particular, it is indicated that clarithromycin is a substance that is perfectly absorbed through the intestinal tract. The process proceeds somewhat slower if the drug is taken at the same time as the meal. But bioavailability does not depend on whether to drink an antibiotic with food or take a pill on an empty stomach.
In the instructions for use of "Fromilide UNO" (reviews note that the drug is well tolerated) it is indicated that in a certain release the tablets belong to the group of drugs of prolonged action. If the product is of this class, it is indicated on the cardboard box. Their adsorption is somewhat slowed down in comparison with conventional tablets, while the indicators correspond to similar capsules of immediate effect. Choosing between prolonged and regular, it is necessary to consult a doctor to determine which option is most suitable for a particular case.
Features
As indicated in the instructions for use of “Fromilide UNO” 500 mg, the maximum concentration of the active compound in the patient’s body is achieved more slowly if a decision is made in favor of a prolonged release. As soon as the drug has reached the greatest amount, the kinetic processes of clarithromycin occur in exactly the same way, and it does not matter what form was used for therapy.
Instructions for use of “Fromilide UNO” 500 mg indicate that the active compound reaches a stable concentration by the third day of administration. The bioavailability of the active component is one third lower when taking the drug in a prolonged form, if the product is used on an empty stomach. Choosing just such a medication, you should take it with food to increase the effectiveness of therapy.
What's inside?
As can be seen from the instructions for use of "Fromilida UNO" 500 (the price of the drug is affordable), the active compound easily penetrates into organic fluids and tissues. In the blood serum, the concentration of clarithromycin is approximately ten times lower than in the patient’s tissues. Up to 20% of the total volume of the active substance is processed as soon as possible, which allows to obtain 14-hydroxy-clarithromycin. This substance is highly effective in relation to certain forms of microscopic life.
In the instructions to “Fromilid UNO” 500 (price reviews mainly contain opinions that the cost of the drug is affordable and justified) it is indicated that when using half a tablet for food, the time required for half-life of the active component is four hours. When using one tablet, the interval is extended to seven hours. About 20-30% of the main substance leaves the body in an unchanged form. If a suspension form is chosen, this proportion reaches 40%. Non-metabolized volumes are excreted in the urine, and others, as processed products.
Special occasion
As follows from the instructions, “Fromilide UNO” (reviews indicate that doctors also pay attention to this when prescribing therapy) in a prolonged form is not intended for the treatment of those who are diagnosed with liver and kidney failure. If creatine clearance is less than 0.5 ml per second, you should refrain from using the drug in this form. If clarithromycin is required, Fromilide UNO is prescribed in the form of an instant preparation.
When to use?
Instructions for use "Fromilida UNO" (reviews of the 500 mg form confirm the effectiveness of the medication) contains recommendations for the use of the drug if otitis media and infection of soft tissues, skin, upper and lower respiratory tracts are detected. "Fromilid UNO" is effective for acute sinusitis, is prescribed for tonsillopharyngitis. You can use the tool if the infection is provoked by mycobacteria (except in some cases).
“Fromilide UNO” also has a good therapeutic effect in a number of other pathologies that are inflammatory in nature and provoked by infection. As indicated in the instructions to "Fromilid UNO", the main criterion for choosing this particular drug is the sensitivity of the harmful pathogenic agent to clarithromycin.
How much do you need?
As follows from the instructions to "Fromilid UNO" 500 (analogues often require the same rules of admission), the tool should be used in tablet form in its entirety. No need to chew, grind the drug. To improve absorption, it is necessary to drink the medicine with a small amount of liquid. If the release of a prolonged form, it is worth using with food, this increases the effectiveness of treatment.
For minors over 12 years of age and adult patients, it is recommended to take one tablet per day, in milligrams it is 500. Fromilide UNO according to the instructions for use (and analogues listed below) should be used in a larger volume if the infectious disease is very severe. Under the supervision of the attending physician, a double dose is allowed. The duration of therapy is not less than a week, but not more than two. It is possible to adjust the duration of the course of treatment in a particular case, if the doctor sees the prerequisites for this.
Unpleasant consequences: what to prepare for?
The instructions for use of Fromilide UNO 500 (you already know the price of the drug) indicate that in a number of cases there is a possibility of side effects. Although the drug is well tolerated, in some cases a negative reaction of the body is still observed, most often from the digestive system. It is known that patients experienced a violation of the digestive tract, and stool disorder. If the diarrhea is severe, prolonged, it is necessary to consult with your doctor and cancel the antibiotic - perhaps this phenomenon is triggered by one of the forms of colitis. There is also the likelihood of stomatitis, distortion of the susceptibility of taste buds. In a very small percentage of cases, under the influence of clarithromycin, liver enzymes can become more active, there is a risk of jaundice.
In the instructions of "Fromilida UNO" there is mention of the possibility of a negative CNS response to clarithromycin - the head may hurt, dizziness, sudden and unpredictable attacks of fear are less common. Very rarely, a negative reaction is recorded from the side of the heart, the vascular system. There is a risk of an allergic reaction if the patient's body is sensitive to any of the components used in the manufacture of the composition. Medical statistics allow us to conclude that side effects, if they are observed, are only mild, this is characteristic of only a small percentage of patients. Fixing the described sensations in oneself, one should consult a doctor, perhaps a replacement with another drug will be made.
When is it impossible?
The instructions of "Fromilida UNO" indicate that the drug is not suitable for people who have had hepatitis in any form. You can not resort to this medicine for severe liver failure. The drug is not intended for the treatment of pregnant women in the first trimester. You can not use the medication for porphyria, while breast-feeding a baby, with intolerance to any of the components of the product, as well as any macrolides.
Certain restrictions are placed on the possibility of using this drug. As indicated in the instructions to “Fromilid UNO”, it does not combine with compounds based on astemizole, terfenadine, pimozide, cisapride.
Interesting position
Like many (including at the price of) analogues, Fromilide UNO (the instructions for use confirms this) is not intended for the treatment of pregnant women. In the first trimester, clarithromycin is strictly prohibited. In later periods, the doctor may occasionally advise stopping on this medication if the possible risks associated with its use are less than the obvious benefit for the patient.
During lactation, it is taken into account that the active compounds pass into breast milk. If an urgent course of therapy is required, "Fromilide UNO" is prescribed, temporarily stopping breastfeeding. Upon completion of therapy, you should check with your doctor whether it is possible to immediately return to the previous practice of feeding a child or if you need to withstand a certain time period.
Mindfulness is the key to safety
As follows from the instructions, Fromilide UNO is prescribed if the benefit exceeds the harm. We are talking about chronic diseases in which the use of this medicine is prohibited. In this case, monitoring of the patient, his health and functioning of vital organs is required. In particular, if chronic liver pathologies are detected, serum should be constantly analyzed, checking enzyme parameters. If the patient is forced to use medications processed by the liver, the concentration of active components in the blood should be checked. A dosage adjustment may be required.
The parallel use of Fromilid UNO tablets and drugs with warfarin and other medicines that have an indirect effect on blood coagulation requires a constant check of the prothrombin time period. If diarrhea while taking “Fromilide UNO” is severe and does not stop, there is a possibility of colitis in a pseudomembranous form. With such a suspicion, treatment is stopped, consult a doctor.
And if you focus?
Medical tests have shown that Fromilid UNO tablets do not interfere with driving and working in situations requiring increased concentration of attention. The tool does not affect the central nervous system of the patient, so you can not introduce additional restrictions in everyday life while taking the medicine.
Overdose
An overdose of Fromilid UNO tablets can be suspected due to diarrhea, nausea and vomiting. Sometimes the head begins to hurt, possibly a state of confused consciousness. Rinse the stomach quickly to prevent more severe consequences. There is no specific antidote, therefore symptomatic treatment is carried out. Hemodialysis does not show a qualitative change in the situation.
What to replace: other forms of release
The closest analogue is the drug Fromilide. Instructions for use "Fromilida UNO", reviews and price are similar to each other. “Fromilide” is presented on pharmacy shelves in tablets of 250, 500 mg of the active substance. Usually these are light yellowish oval capsules. You can purchase granules intended for the preparation of a suspension. This release option is needed for the treatment of minors, since it includes a flavor. The granules themselves are small, the shade varies from white to light yellow. The suspension is used orally.
You can find other antimicrobial names, the main component of which is clarithromycin. The most famous are Bacticap and Clarithromycin. The names registered in our country include Lekoklar, Romiklar and Klarbakt. In some cases, the doctor recommends stopping at Klacid or Clubax. Pilobact, Biotericin have a good reputation. It is possible to replace with some other names, if the doctor recommends stopping on them. Also on sale are such medicines that contain clarithromycin and additional substances, which makes them complex, especially useful in certain diseases.
Treat kids
"Fromilide UNO" is not intended for the treatment of children under the age of 12 years. Another limitation is related to weight - the drug is prescribed only if the child is heavier than 33 kg. But in the form of a suspension "Fromilid" can be used from six months of age. Regarding even earlier use, there is no exact information that would confirm the effectiveness and its safety for the patient, therefore the medication is not recommended for admission.
Popular analogues: "Klacid"
Although this drug is not the cheapest (for one package in pharmacies they ask up to 400 rubles), but it is considered reliable and effective. The tool is suitable for the treatment of both children and adults. The medication is also based on the semisynthetic antimicrobial compound clarithromycin. The effectiveness of taking the drug is observed with infection with staphylococcus, streptococcus, mycoplasmas, mycobacteria, gonorrhea. The tool does not help with the causative agent of tuberculosis, but it shows good efficacy against hemophilic bacillus. You can use "Klacid" with campylobacteriosis. The active compound shows good results in pathologies provoked by Helicobacter pylori.
"Klacid" is suitable for the treatment of young patients, but only under the strict supervision of a doctor. The specialist selects the appropriate dosage option, evaluating not only the age and diagnosis, but also the weight of the patient. Based on general information about the patient's condition, it is possible to choose the best form option, since Klacid is available in several versions.
When will it help?
Klacid has established itself as an effective remedy for certain forms of gastritis, skin infections and mycobacterial infection, although it is not used against tuberculosis. “Klacid” can be used for pulmonary, bronchial diseases caused by infections sensitive to the active compound. An especially effective drug will be for staphylococcus and other bacterial pathologies whose pathogens are susceptible to clarithromycin. Assign "Klacid" and diseases of the nasopharynx, nose, if an infectious nature is detected. You can also use the drug for complications provoked by such violations, if the microflora is sensitive to clarithromycin.
What's on sale?
"Klacid" is presented in tablet form. One capsule contains 250 or 500 mg of active compound. The exact amount is indicated on the carton. There is also a lyophilisate on sale. Dosage - 500 mg. The medication is intended for the preparation of a solution used parenterally. There are bottles with a preparation for suspension. Dosage - 125 mg, 500 mg. Volume - 5 ml.
How to treat children?
In the form of a suspension, "Klacid" can be used as early as six months of age. Usually the drug is taken twice daily. The doctor calculates the specific serving volumes based on the disease, age, and body weight of the patient. So, if the weight is less than 8 kg, it is necessary to take 7.5 mg of the active compound per kilogram at a time. , .
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