Vein diseases are a problem for both men and women. They can cause not only disability, but also death. Therefore, such problems necessarily require high-quality therapy. One of the tools that is used today in the treatment of diseases of the vascular system is Detralex. Instructions for use, analogues, reviews of this medicine will be discussed below.
Why are vein diseases scary?
The human circulatory system is very extensive, because the blood supplies nutrients to every cell of the body, and helps to remove spent and unnecessary components from all organs from the body. From the heart, oxygen-enriched blood travels through the arteries. But Vienna is a transport system of already used biological fluid, which is sent to the liver for cleaning.
On the way back, unnecessary substances and toxins impede the blood flow, which is supported by weaker mechanisms of the venous valves, the work of certain muscle groups, and mechanically by activating the vessels of the foot during running and walking. Therefore, a sedentary lifestyle, factors affecting the forced narrowing of the lumen of blood vessels, for example, smoking and alcohol, stress, eating large amounts of fatty foods and dishes, some pathologies of the body lead to disruption of venous blood flow and its stagnation.
This causes the appearance of cholesterol plaques, blood clots, the toxic effects of accumulated waste products, which the blood cannot fully remove for disposal. Treatment and prevention of such pathological conditions of veins may include the use of the Detralex group of drugs. Instructions, reviews, analogues are considered in the article, which gives full knowledge about the work of these medicines.
What works in the drug?
Violation of the transport function of the veins becomes the cause of serious health problems. And before you find out the method of application for the Detralex drug, you need to find out what its work is based on. The manufacturer of the drug, the pharmaceutical corporation Les Laboratoires Servier, indicates that it contains a complex compound: a purified micronized flavonoid fraction consisting of diosmin and flavonoids converted to hesperidin. Flavonoids are organic compounds of plant origin related to the aromatic series.
Diosmin as a plant component is found in a shrub or grass of Dubrovnik, but in medicine semi-synthetic diosmin is used. In its functionality, it corresponds to another flavonoid - hesperidin, which is contained in large quantities in the peel of the fruits of citrus trees. The drug itself, under the trade name "Detralex", contains 5 organic components-flavonoids: diosmin, diosmethine, hesperidin, isoroifolin and larin. Their synergistic effect allows to obtain significant results in the prevention and treatment of venous diseases.
Pharmaceutical affiliation
As the instructions for use indicate for the Detralex 1000 drug, it belongs to the pharmacological group of angioprotectors and microcirculation correctors in combinations. This is a fairly extensive community of drugs that work in the cardiovascular system. They are diverse both in their origin and in principle of action.
If we talk about their properties in general, they have an antispasmodic effect on the vascular wall, causing vasodilation, normalize blood microcirculation and blood flow. Also, these substances are able to actively influence the metabolic processes that occur in the walls of blood vessels, help the body remove excess fluid, which removes puffiness. All this information contains the instructions for use for the Detralex preparation. Reviews of experts confirm the effectiveness of the tool.
In what pharmaceutical forms is the drug available?
Under the trade name "Detralex" several pharmaceutical forms of drugs are combined:
- Detralex 1000 tablets, the method of use of which is specified in the instructions enclosed in each package of the drug containing 18, 30 or 60 tablets;
- Detralex suspension in a 10 mg sachet, put in 15 or 30 pieces in one cardboard box along with instructions for use;
- Detragel gel, which can be purchased in an aluminum tube of 40 mg.
The manufacturer of the Detralex line, the French pharmaceutical company Laboratory of Servier Industry, in each product annotation called Detralex indicates that the amount of active ingredient in the tablets is 1,000 mg, and 1,000 mg is also contained in one sachet. But in 1 gram of gel contains 100 IU of the active complex component, consisting of sodium heparin, escin and phospholipids. In addition, each form of the drug in its composition has auxiliary components that give the drug the claimed pharmaceutical form.
How does the active component work?
Vascular diseases cause many health problems and well-being. After all, the correct work of the blood flow in many respects ensures the quality work of each cell. In order to ensure uninterrupted blood transportation, in some cases it is necessary to resort to the help of special medicines, one of which is Detralex. The method of application of each type of drug with this name allows you to most effectively use its medicinal properties.
Interacting with norepinephrine - a hormone-neurotransmitter, diosmin enhances its vasoconstrictor effect. This process increases the tone of the veins, which reduces the venous capacity, the extensibility of these vessels and, as a result, stagnation. Venous blood flow, which is enhanced by the work of the drug with bioflavonoids of Dubrovnik and citrus, discharges hyperpressure in the veins, which is especially noticeable in patients suffering from chronic venous insufficiency.
As it is known about the Detralex drug from the instructions for use and reviews of professionals, the active component promotes the activation of lymphatic drainage by increasing the frequency of contractions of the lymph nodes, as well as increasing the total number of functional capillaries of the lymphatic system. At the same time, the drug reduces the diameter of the lymphatic capillaries, thereby lowering introlymphatic pressure. Having the ability to work at the level of microcirculation, diosmin and hesperidin reduce the permeability of small blood vessels, while at the same time increasing their resistance.
Such a functional of the drug provides a protective effect against damage, which affects the microcirculation of blood flow and lymph flow. Tablets and suspension significantly reduce the expression of endothelial adhesion molecules, i.e., pulling them to each other, which inhibits adhesion, as well as the migration and activation of leukocytes at the capillary level. All this causes a decrease in the release of inflammatory mediators, mainly prostaglandins and free oxygen radicals.
The pathway of the drug in the body
One of the commonly prescribed drugs to normalize venous blood flow is Detralex. The method of use will depend on the form of release of the drug, because one name combines 3 types of the drug. A complex of semisynthetic bioflavonoids works in them, and heparin and aescin in the gel. The manufacturer determined the optimal amount of active complex to achieve the claimed effect - 1,000 mg per day.
This amount corresponds to the pharmaceutical form in 1 unit, be it a tablet or a sachet. The drug enters the bloodstream from the gastrointestinal tract, where, reaching the veins, it begins its work. The half-life of substances is about 11 hours. Passing through the liver, bioflavonoids are actively metabolized to phenolic acids. In unchanged form with urine, about 14% of the taken amount of the drug comes out of the body. Basically, the drug is excreted in feces.
The manufacturer of the drug has provided several pharmaceutical forms for more effective work of the Detralex drug. The method of administration and dose required by the patient are prescribed by a specialist. He also recommends the duration of use and other drugs to obtain adequate therapy results.
In what cases is the medicine used?
Describes in which cases the drug "Detralex 1000" is prescribed, instructions for use. Violations of the functional veins lead to many health problems. The drug is recommended for use in the treatment of the following diseases and conditions:
- hemorrhoids;
- venous insufficiency;
- lymphatic edema.
The drug helps to solve the problems of impaired venous-lymphatic blood flow: severity and pain in the legs.
When the drug can not be used?
Instructions describe how the preparation for veins works for all forms of Detralex release. Reviews of experts are advisory in nature, mentioning that treatment should be prescribed for medical reasons. Despite the fact that the drug as an active component includes a complex of bioflavonoids, it has its contraindications.
This is a special sensitivity to components, both active and auxiliary. Also, the Detralex line of drugs cannot be used in therapy for women who are breast-feeding a baby, since no clinical trials have been conducted.
Unwanted action
The use of Detralex is popular in the field of problems with the vascular system in general and with venous blood flow in particular. In drugs in the form of tablets or suspensions, bioflavonoids work. But the drug can not be used without consulting a specialist. This line of drugs can have the following undesirable effects on the body:
- headache;
- abdominal pain;
- dizziness;
- diarrhea;
- dyspepsia;
- itching
- colitis;
- hives;
- general malaise;
- angioedema;
- swelling of the lips, eyelids, face;
- vomiting
- rash;
- nausea.
All these side effects with the action of the drug were manifested in extremely rare cases. Patients are advised to inform their doctor about any changes in their well-being during treatment with Detralex.
How to take the medicine?
For venotonics "Detralex", the application depends on the pharmacological form, because the manufacturer has provided several possibilities for using the drug. So, tablets containing 1,000 mg of the active ingredient should be taken 1 time per day, preferably in the morning during breakfast. Potential buyers should remember that Detralex 500 is not available in pharmacies.
The way of using the tablets implies such a dosage only if it is difficult for a person to swallow a 1,000 mg tablet whole, then it can be divided into two halves and swallowed separately. For the treatment of venous-lymphatic insufficiency, the drug is available in packs of 30 and 60 tablets. The course of treatment of such diseases can be quite long - up to 12 months, so the purchase of a large package of the drug will be more beneficial from the material side.
The manufacturer produces Detralex tablets for the treatment of hemorrhoidal problems. The method of use for hemorrhoids of such a drug implies the following treatment regimen: in the first 4 days of illness, take 1 tablet in the morning, at lunch and in the evening during meals. Then another 3 days take 2 tablets per day - morning and evening. The course of treatment is fully provided by one pack of 18 tablets.
Sachet suspension is a novelty in the line of products under the brand name Detralex. This form of the drug with the active component has the same composition of bioflavonoids as tablets, but the liquid consistency implies the use in a place convenient for the patient, because the suspension can not be washed down with water, and it is convenient to take the sachet on the road, for work. If hemorrhoids treatment is necessary, then sachets are also used in 3 pieces per day (morning, afternoon and evening) in the first 4 days of therapy, in the next three days the dosage is reduced to 2 sachets - 1 in the morning and 1 in the evening.
The drug in the form of an external agent "Detragel" is applied only in a thin layer, without rubbing, especially with thrombophlebitis. No compress is used on top, but compression stockings or bandages can be worn. Apply the gel 2-3 times a day for 15 days. If there is no improvement, the doctor should choose other methods of treatment. A long course of use of this drug is possible only on the recommendation of a specialist and under his regular monitoring of the course of the disease.
Overdose
For each pharmaceutical form of Detralex, the application has its own strict recommendations, therefore, taking more of the drug than it should be possible only consciously. But such a step will not make the treatment faster or better. It was a convenient form of medication that allows you to clearly control the regimen and dosage, which caused the lack of information about an overdose. But if this happened, then the patient must be urgently taken to a medical institution to provide qualified care.
Reviews of specialists and patients
Venotonics and venoprotectors are necessary means of preventing diseases of the vascular system. In addition to the instructions for use developed by the manufacturer, a lot of important information is given about the Detralex product line. Analogues of the drug also help to find the opinion of specialists and patients. A drug based on bioflavonoids, diosmin and hesperidin receives a variety of reviews from patients taking these drugs.
There are grateful responses indicating that the tablets and gel helped get rid of the symptoms of venous blood flow disorders, such as heaviness and pain in the legs, painful and uncomfortable sensations with hemorrhoids. But all those who left positive opinions about the medicine note that they took it several times a year. There are responses and extremely negative when people write about the meaningless use of pills, which had no effect, but only indicate regret about wasted funds.
By the way, high cost as a huge minus is noted in most responses. For specialists, the instruction for use is the recommendation for the appointment of the drug "Detralex". Analogues of this drug work in one direction, regardless of the form of release, whether it is a tablet, ointment or suppository.
The Detralex line allows you to treat venous problems both internally and externally. This is a great merit of the drug manufacturers. Doctors consider Detralex an effective treatment for venous and lymphatic stasis. They also note a small number of contraindications to the appointment of tablets, suspensions or gel, as well as a rare manifestation of undesirable effects.
Are there any similar drugs?
All significant information is told about the Detralex preparation. Its analogs should be included in the group of venotonics and venoprotectors. If the drug works on an identical substance, then it is called identical. For the Detralex drug, it will be such drugs as Venolife, Stimulven, Detravenol. In them, the purified component is the purified flavonoid fraction, which contains diosmin and other flavonoids in terms of hesperidin.
But in pharmacies you can buy drugs that work on diosmin, for example, Phlebodia, Phlebofa, Venolek, and Vazoket. What medicine to use in treatment, a specialist will tell, given the existing problem of the vascular system and general health.
How to buy and how to store medicine?
Drugs that help eliminate venous and lymphatic currents can be purchased at any pharmacy, including the Detralex drug. The method of application is determined by the form of release, but the storage conditions for tablets, suspensions and gel will be the same. Medicines should be kept at room temperature not exceeding 25 0 C, without access to sunlight. In the pharmacy, any drug from the Detralex venotonic and venoprotector line can be purchased on demand without presenting a prescription from a doctor.
Discomfort, pain, heaviness arising in the legs are possible signs of varicose veins. This condition should be taken very seriously, visit a specialist, undergo a quality examination. If a violation of the lymph and blood flow system is established, the doctor may recommend Detralex therapy.