What is and how is the drug Gloe 500 used? Instructions for use, reviews and features of the mentioned medication are described below. Also in the materials of this article you will find indications for taking this medicine and prohibitions on its use.
Drug packaging, its form, description, composition
In what form is the medicine “Glevo” made? Reviews say that this drug goes to the shelves of pharmacies in the form of tablets. They have a brick-red film sheath, round and biconvex, and a fault line on one side.
What does the medicine “Glevo” contain? Reviews of doctors report that the main substance of this medicine is levofloxacin. It also includes auxiliary ingredients such as crospovidone, microcrystalline cellulose, povidone, starch and magnesium stearate.
The composition of the tablet shell contains: dibutyl phthalate, hypromellose, titanium dioxide, macrogol, red dye (iron oxide) and talc.
On sale, the medicine "Glevo" comes in blisters that are packaged in packs of cardboard.
Drug action
What is the Gloe 500? Instructions for use, reviews state that this is an antibacterial agent belonging to the fluoroquinolone group (it has a wide spectrum of activity).
The main component of this drug (levofloxacin) is able to block DNA gyrase (that is, topoisomerase 2), as well as topoisomerase 4. In addition, this substance disrupts the cross-linking and supercoiling of DNA breaks, inhibits its synthesis, and causes morphological changes (deep) in cell membranes bacterial walls and cytoplasm.
The drug "Glevo", reviews of which are ambiguous, is active against many gram-positive aerobic microorganisms.
Kinetic Features
Where is the absorption of the drug "Glevo"? Instructions, reviews report that when you take the medicine inside, it is quickly and completely absorbed from the intestine. Eating practically does not affect the completeness and speed of absorption of the drug.
The bioavailability of this drug is 99.5%, and the maximum concentration in the blood is observed after 2 hours.
The relationship of the drug with plasma proteins is approximately 33-40%. It penetrates well into tissues and organs, especially the lungs, sputum, bronchial mucosa, polymorphonuclear leukocytes, urogenital organs and alveolar macrophages.
In the liver, a small part of the drug is oxidized or deacetylated.
The half-life of this medicine is 6-8 hours. It is excreted from the body through the kidneys.
Indications
When should I use the Glevo antibiotic? Reviews of doctors say that this remedy is effective in inflammatory and infectious diseases caused by bacteria that are sensitive to the drug. Thus, the medication in question is prescribed for infections:
- ENT organs (including acute sinusitis);
- infections (uncomplicated and complicated) of the kidneys and urinary tract (including prostatitis and acute pyelonephritis);
- respiratory tract, or rather its lower sections (including community-acquired pneumonia and exacerbations of chronic bronchitis);
- genitals;
- abdominal cavity (in combination with agents that affect the anaerobic flora);
- soft tissues and skin (including festering atheroma, furunculosis and abscesses).
Bans to use
Under what conditions should not be prescribed the antibiotic "Glevo"? Reviews indicate the following contraindications to this remedy:
- pregnancy period;
- epilepsy;
- minor age;
- damage to the tendons that arose during previous treatment with quinolones;
- breast-feeding;
- hypersensitivity to levofloxacin and other fluoroquinolones.
With extreme caution, the drug in question should be prescribed to the elderly and (due to the high probability of a decrease in kidney function), as well as with a lack of glucose-6-phosphate dehydrogenase.
Glevo tablets: instructions for use
Reviews report that this medication should be taken orally twice a day. Tablets must be swallowed in its entirety. They must not be chewed (it is advisable to drink plenty of water).
The drug can be taken before meals or between meals.
The dosage of this agent is determined by the severity and nature of the infection, as well as the sensitivity of the pathogen.
- With sinusitis, the medication is prescribed at 500 mg (once a day) for two weeks.
- With exacerbation of chronic bronchitis - 250 or 500 mg (once a day) for one week.
- With community-acquired pneumonia, 500 mg (twice a day) for two weeks.
- For uncomplicated urinary tract infections - 250 mg (once a day) for three days.
- With prostatitis - 500 mg (once a day) for one month.
- For infections of the urinary tract of a complicated nature (including pyelonephritis) - 250 mg (once a day) for 10 days.
- In infections of soft tissues and skin - 250-500 mg (twice a day) for two weeks.
- In case of infections of the abdominal cavity - 500 mg (once a day) for two weeks (in combination with antibacterial agents acting on the anaerobic flora).
With impaired liver function, a special selection of doses is not required, since the metabolism of levofloxacin in the liver occurs to a small extent.
For older people, changing the dosage regimen is not required, except for low QC.
Treatment with this drug should be continued for about 48-78 hours after eradication and normalization of body temperature.
If you skip taking the medication, you should take the pill as soon as possible. Further, it is required to continue the use of the drug according to the prescribed scheme.
Side effects
What are the negative effects of the drug "Glevo 500"? Reviews indicate the following reactions:
- nausea, decreased blood pressure, vomiting, vascular collapse, diarrhea, hypoglycemia, indigestion;
- arthralgia, decreased appetite, muscle weakness, abdominal pain, impaired vision and hearing;
- pseudomembranous enterocolitis, interstitial nephritis, increased liver transaminase activity , rhabdomyolysis;
- hyperbilirubinemia, worsening of smell, tactile and taste and sensitivity, hepatitis, tendonitis, dysbiosis;
- myalgia, tachycardia, acute renal failure, urticaria, atrial fibrillation;
- headache, hypercreatininemia, dizziness, hemolytic anemia, weakness, agranulocytosis;
- drowsiness, swelling of the skin and mucous membranes, insomnia, anaphylactic shock, tremor, vasculitis, anxiety, neutropenia, paresthesia;
- allergic pneumonitis, fear, suffocation, hallucinations, exacerbation of porphyria, confusion, pancytopenia;
- depression, thrombocytopenia, motor disorders, persistent fever, epileptic seizures, tendon rupture;
- leukopenia, pruritus and flushing of the skin, asthenia, exudative malignant erythema, eosinophilia;
- toxic epidermal necrolysis, bronchospasm, development of superinfection, hemorrhage, photosensitivity.
Analogs and cost
The price of this tool is about 170-250 rubles. In some cases, this drug is replaced with drugs such as Levolet, Zolev, Toxof, Lebel, Levofloxacin, Levobax, Levoflox, Levobact, Levotor, Levokilz, Levostad, Levoksa, Levomak, Levoksimed.
Antibiotic "Glevo": reviews of patients and doctors
Consumer reviews about the drug "Glevo" are ambiguous. They can be divided into 2 groups: one part is pleased with the effect of the drug, as it helps to cope with infectious diseases with minimal side effects, and the other considers the medication to be ineffective.
As for doctors, their opinion boils down to the fact that the drug "Glevo" is a strong antibiotic, which can be taken only after consulting a doctor. By the way, most experts, together with the drug in question, recommend taking probiotics so as not to disturb the intestinal microflora.