Any medications should be used strictly as prescribed by the doctor and after a thorough study of the instructions. Gordox medication is no exception. A detailed description will be provided below.
The composition of the drug and the form of release
Gordox medicine is presented in the form of a solution for injection. It is an inhibitor of fibrinolysis, the main active ingredient of which is aprotinin. As auxiliary elements, benzyl alcohol, sodium chloride, and also purified water are used.
Gordoks solution cannot be used for self-medication and is dispensed in pharmacies only by prescription. 10 ml are packaged in transparent ampoules, which are in a cardboard box. Less commonly, the drug is presented in the form of a concentrate for the preparation of a solution and has the form of a powder.
Indications
The drug "Gordox" can be prescribed only to adult patients. Most often it is used during coronary artery bypass grafting as a prophylaxis of blood loss. In addition, the medicine can be prescribed for various forms of pancreatitis - acute and chronic. Often, a medication is used in surgery when there is a need for treatment of the pancreas. Gordoks solution can be used during diagnostic tests for the prevention of pancreatic enzymatic autolysis.
Any surgical intervention is characterized by severe blood loss. The most dangerous in this regard are surgical operations on the prostate gland and lungs, since they are highly likely to cause bleeding. Blood loss due to hyperfibrinolysis can be controlled using the drug Gordoks. It is prescribed for serious injuries of the skin (burns, cuts, allergic reactions).
Gordoks solution can be prescribed to pregnant women in the last trimester. The medicine helps to protect a woman in labor from serious blood loss. In addition, the risk of amniotic fluid embolism is significantly reduced.
The drug can be used as an adjunct in burns, toxic or traumatic shock. Apply it with angioneurotic tissue edema. Often, the drug is prescribed after surgery as a prophylaxis of embolism and bleeding in the lungs. In case of polytrauma, the Gordox solution in ampoules helps to avoid
fat embolism. Especially often it is prescribed for fractures of the bones of the skull and lower extremities.
Who is not prescribed Gordox medication?
The medicine has practically no contraindications. Due to the lack of a sufficient number of studies, medication is not prescribed for minors. The safety of the use of funds by children has not been established to date. In rare cases, sensitivity to individual components of the drug may occur. In the event of individual intolerance, the Gordox solution is immediately canceled.
During pregnancy, the medication is not contraindicated. But it should be used only as directed by the doctor. The medicine can only be used if the potential benefit to the mother significantly exceeds the harm to the fetus. Women in labor who have taken the Gordox medicine leave reviews mostly positive. The medicine helps to avoid large blood loss during ruptures.
The use of the drug during lactation has not been studied. Theoretically, the medicine is absolutely safe if it is ingested by breast milk. The fact is that the Gordoks product does not have bioavailability when used internally.
special instructions
Aprotinin, which is the main active component of the drug, can cause serious allergic reactions. With primary use, side effects almost never occur. With caution, you should use the medication repeatedly. And before using the Gordoks solution, the instructions for use should be studied first. In rare cases, anaphylactic reactions may occur. Therefore, in a hospital, before the introduction of the main dosage of the drug, a sample is administered, which is 1 ml. The doctor monitors the patient's response for 10 minutes. If no side effects are observed, the main norm of the drug “Gordoks” is introduced.
In rare cases, the patient may not respond to the trial dosage. And with the introduction of a therapeutic dose, serious allergic reactions are observed. In the event of any phenomena that significantly worsen the patient’s well-being, the use of the Gordoks medicine immediately ceases.
When using the drug, it should be remembered that benzyl alcohol is included in its composition. Based on this, the drug "Gordox" should be prescribed with caution. The dosage of benzyl alcohol per day is calculated based on the patient's body weight (90 mg per 1 kg of body weight).
The Gordoks solution tends to settle at the bottom of the storage tank. If the shelf life of the product has not yet expired, but a precipitate has already formed, it is better not to use the drug. Before starting therapy, the medication must be subjected to a thorough visual examination.
The medicine is not contraindicated for use in the elderly. In rare cases, a dose adjustment is necessary. With caution, a medication is prescribed for patients with hepatic and renal failure.
Gordoks does not affect the driving or other complex mechanisms. But it should be noted that the medication is prescribed most often in severe cases when the patient is in the hospital. Therefore, the need to drive a car is initially absent.
Dosage
Gordox medication is administered only intravenously. This is most often done using dropper systems. The drug is administered slowly at 5-10 ml per minute. Only the main veins are used, through which other medicines should not come. Due to the fact that patients often develop anaphylactic or allergic reactions, a test injection is made 10 minutes before the main dose. Its volume is 1 ml. The doctor carefully monitors the main indicators of the patient. Therapy can be continued if no adverse reactions occur.
The initial dosage for the treatment of an adult patient is 100-200 ml. The medicine is administered gradually over a period of 10-15 minutes. Further, the dosage can be increased by another 200 ml. To ensure normal dilution of the drug, increasing the dosage is recommended only during the recirculation period. The total volume of the drug during the entire course of treatment should not exceed 700 ml.
In case of side effects, the dosage of the drug can be adjusted. To a lesser extent, the drug is used in patients older than 60 years. Cases of overdose have not been identified previously.
Side effects
In patients who first use the drug "Gordoks", side effects occur quite rarely. Serious allergic reactions can develop with repeated use of the medicine. The most dangerous for patients is anaphylactic shock. But such a side effect occurs only in 1% of cases. With any changes in well-being, a doctor's consultation is required. Most often, side effects develop with repeated use of the Gordox medication within 6 months. Before using the medicine, a test dose is required.
Allergic reactions are most often manifested by disorders of the cardiovascular system. The patient may accelerate heart rate, increase blood pressure. From the gastrointestinal tract, unpleasant symptoms such as nausea, diarrhea, and vomiting can be observed. Less commonly, skin rashes and itching may appear. There may be disorders of the respiratory system, which manifest themselves in the form of asthma or bronchospasm. With any manifestations of hypersensitivity, aprotinin-based drugs are immediately canceled. The patient should be given immediate care. The stories are familiar with deaths due to the use of the drug in patients with a tendency to allergic reactions.
In some cases, disorders of the urinary system can be observed. Renal function may be impaired . Renal failure rarely develops. The decision to stop using the drug is made only by the doctor. If side effects are not significant, therapy continues. Only the dosage can be adjusted.
Interaction with other drugs
In conjunction with other medicines, the drug Gordox should be used with caution. Instructions for use describe the means with which it is not recommended to use the solution at all. Drugs based on alteplase, urokinase, streptokinase together with aprotinin should not be taken. The problem is that the activity of all of the above components will be significantly reduced. This means that treatment will not give the desired result.
Gordox is fully compatible with glucose and hydroxyethylated starch only. Use the medicine with other drugs is only after consulting a doctor.
Terms and conditions of storage
Absolutely unpretentious is the medicine "Gordreks". The instruction says that it must be stored at a temperature not exceeding 30 degrees in a dry dark place. Leaving the solution in the refrigerator is not necessary. But the drug is still worth hiding from children. Any medication is potentially dangerous for a little man. The ideal place to store the Gordox solution is the farthest shelf in the cabinet.
The medication has a fairly long shelf life, which has 60 months from the date of release. It is worth noting that the medicine is dispensed with a prescription. Rarely, there are times when the solution is not completely consumed during treatment.
Gordoks. Analogues of the drug
Sometimes it is not always possible to find a drug with that name in pharmacies. But there are drugs that have the same pharmacological effect, and also have a similar composition. If it is not possible to use the Gordox solution for pancreatitis, you can use the drug Trasilol. This medicine is also made on the basis of aprotinin. The medicine is used not only for pancreatitis. It is prescribed for operations or diagnostic tests on the pancreas. In addition, the medication allows you to stop post-traumatic as well as postoperative bleeding.
The medicine is not prescribed for underage patients, as well as for people with a tendency to develop allergic reactions. Use the drug with caution in elderly patients, as well as in women during the period of gestation. Adverse reactions during the initial use of the solution "Trasilol" occur quite rarely. If there is a need to use the drug again within 6 months, there is a risk of anaphylactic reactions. To avoid any side effects, a test dose is administered before starting therapy.
The drug "Trasilol" is dispensed in pharmacies with a prescription, as is the drug "Gordoks." Application is possible only as directed by a doctor. All aprotinin-based medicines can only be used in a hospital setting.
Less commonly, you can find a medicine called "Aprotex", which has completely similar properties.
The cost of the drug and reviews about it
For patients who are in a difficult postoperative period, the drug “Gordoks” significantly improves their well-being. Reviews show that the medication helps to stop bleeding faster. As a result, blood pressure is normalized. Negative reviews about the medication can be heard only from those patients who are hypersensitive to aprotinin. Serious allergic reactions may occur that require drug withdrawal. But this does not mean at all that the Gordoks remedy is not effective. Instructions for use states that before starting therapy, a test injection should be performed.
Effective, according to doctors, with pancreatitis is Gordoks solution. Analogs for the treatment of the disease can also be used. But they are most often more expensive. Gordox can not be called a cheap drug either. Its cost in some pharmacies is about 10,000 rubles. And this is just one pack per 10 ml. The maximum dosage may be 700 ml per course. It is easy to calculate how much the treatment will cost. This is perhaps the biggest minus that pushes patients away from the drug. But in some cases you do not have to choose. The use of Gordox is vital.
Acceptance of any medications should be agreed with your doctor. Before using the Gordoks product, the instructions for use should be studied carefully. Negative reviews arise only for those who are self-medicating. After all, the solution may be incompatible with certain medications. Such treatment will not only not give positive results, but may also be hazardous to health.