How to use the medication "Neotrizol" (candles)? Instructions for use of the above suppositories will be presented below. Also from the materials of this article you will learn about what this drug helps from, what features are inherent in it, what patients talk about it and whether it has side effects.
Packaging, composition
Neotrizol suppositories, the instruction of which is enclosed in a cardboard box, contain such active ingredients as miconazole nitrate, ornidazole, neomycin sulfate and prednisolone. They are produced in blisters of 8 pieces.
Pharmacodynamics of the drug
What is the mechanism of action of the drug "Neotrizol"? Instructions for use states that it is an antibacterial agent that has an antifungal effect. It exhibits an active effect against gram-negative bacteria and gram-positive microorganisms, penetrates their structure and blocks protein synthesis.
Drug properties
The effectiveness of this medicine is due to its composition.
Neomycin is an antibiotic substance that belongs to the group of aminoglycosides. It actively acts against gram-negative bacteria, and is also very effective against gram-positive microorganisms.
After applying the medication, neomycin immediately penetrates the structure of bacterial cells, and then blocks the synthesis of proteins, which are essential for their survival.
Miconazole is an antifungal agent intended for topical treatment of vulvovaginal candidiasis. This element is effective in relation to Candida vulvovaginalis.
As for prednisone, it is a synthetic corticosteroids. It is used to reduce the severity of signs of various inflammations. This element is able to inhibit the production and release of inflammatory mediators. It also slows down proliferative processes and significantly reduces the likelihood of scar formation.
Pharmacokinetics
What kinetic parameters are inherent in the drug "Neotrizol"? The instruction reports that with local use of ornidazole, its concentration in the tissues of the vagina noticeably exceeds the concentration achieved with intravenous administration and oral administration.
This medication does not have a systemic effect. After the use of suppositories, neomycin penetrates the structure of the bacterial cell. This happens due to the increased production of abnormal proteins. They block the production of bacterial elements that are essential for their survival.
With topical use of the drug, its high activity is noted. Miconazole has a toxic and selective effect on yeast-like fungi of the genus Candida.
As for prednisolone, with local use it reduces the severity of signs of the inflammatory process, including hyperemia. Its systemic effects have not been recorded.
Indications for use
What is prescribed the medication "Neotrizol" (candles)? Instructions for use states that this drug is actively used to treat gynecological diseases such as:
- vaginitis of various etiologies;
- bacterial vaginosis;
- mixed infections, including anaerobic infections, trichomonads, gardnerella, yeast-like fungi, leptotrix.
For prophylactic purposes, the drug in question is used before surgery for gynecological diseases, as well as vaginal sanitation before abortion or childbirth, before and after using intrauterine contraceptives, diathermocoagulation of cervical erosion, and before intrauterine examinations.
Contraindications
What contraindications does Neotrizol have? The instruction says that there are not many prohibitions on the use of this tool. It is not prescribed only with increased patient sensitivity to drug substances.
Candles "Neotrizol": instruction
Doctors' comments about this drug report that it should be administered deep into the vagina in the amount of one candle, at night. After this procedure, the patient needs to be in a supine position for about ¼ hour (maybe a little longer).
The average duration of therapy with this drug is 8 days. During menstruation, treatment is not interrupted.
It should also be noted that after the disappearance of all symptoms of the disease, the use of vaginal tablets must be continued at the same dosage (until the entire course is completed).
If after 8 days the signs of the disease have not disappeared, then you need to contact a gynecologist. After examination and examination, a specialist can prescribe repeated therapy with the same remedy.
How to use the drug "Neotrizol" for preventive purposes? The instruction says that for the prevention of gynecological diseases, this medication is also used for 8 days.
Route of administration
How should vaginal suppositories “Neotrizol” be administered? The instruction contains the following instructions for action:
- Place the vaginal tablet in the included applicator.
- Immerse the applicator with the tablet in boiled water, the temperature of which is 30-40 degrees (for several seconds).
- Carefully guide the applicator with the tablet into the vagina (as deep as possible), lying on your back.
After the procedure is completed, the applicator is removed from the vagina, disassembled into parts and washed thoroughly in warm soapy water. Then the device is dried at room temperature, collected again and used as intended.
Side effects
Does the drug "Neotrizol" have side effects? The instruction says that this tool is not toxic. It does not cause sensitization.
The medication is fairly well tolerated by all patients. Very rarely, it can cause cramping and headaches, itching, irritation, burning, hives, and skin rashes.
It is necessary to stop using candles with hypersensitivity to their components or the occurrence of irritation.
Interaction with other medicines
Clinically significant interactions of the drug "Neotrizol" with other medicines have not been identified. Systemic absorption of prednisone must be taken into account with a pronounced local inflammatory process.
Special recommendations
When using systemic corticosteroids, constant monitoring of the patient’s condition with heart failure, osteoporosis, serious emotional disorders, tuberculosis, diabetes mellitus, myopathy, glaucoma, liver failure, gastrointestinal ulcer, epilepsy, myocardial infarction and hypothyroidism is required.
Despite the fact that the drug "Neotrizol" is used topically, its systemic absorption is possible with inflammation of the vagina.
With extreme caution, vaginal suppositories should be given to people with nonspecific colitis, severe pseudoparalytic myasthenia gravis, new intestinal anastomoses, and diverticulitis.
Pregnant women, children, and nursing mothers are not prescribed this drug.
Reviews about the drug
Most reviews of Neotrizol suppositories are positive. Patients claim that this drug contributes to the rapid treatment of various gynecological diseases. Most often it is prescribed for vaginitis and bacterial vaginosis. Also, this medication effectively treats mixed infections.
Now you know what Neotrizol vaginal tablets are. Instructions, reviews about them are described in this article. Experts do not recommend using this medication at their discretion. It must be used only as directed by the gynecologist.