Gastrointestinal ulcers arise for various reasons. However, such diseases are always treated the same way. Along with proper nutrition, taking enzyme preparations and inhibitors of H + -K + -ATPase, doctors must include antiulcer drugs in the treatment regimen. One of these medicines is Novobismol. The price of this medicine, its properties, indications, methods of use, analogues and contraindications will be considered in this article.
Description, composition, shape and packaging
What does the Novobismol preparation contain? Instructions for use report that the active substance of this medication is bismuth tripotassium dicitrate. As auxiliary components, potassium polyacrylate, corn starch, povidone K 30, magnesium stearate and macrogol 6000 are used.
On sale round biconvex cream-white tablets without any odor come in contour cells placed in cardboard boxes.
Pharmacology of the drug
What are Novobismol tablets? Instructions for use indicate that it is an antiulcer drug with bactericidal activity against Helicobacter pylori. It has an astringent and anti-inflammatory effect.
In the acidic environment of the stomach, the drug forms insoluble bismuth citrate and oxychloride, as well as chelating compounds in the form of a protective film on the surface of erosion and ulcers.
Increasing the formation of mucus, the synthesis of prostaglandin E and the secretion of bicarbonate, the drug in question activates cytoprotective mechanisms, increases the resistance of the gastrointestinal mucosa to the effects of hydrochloric acid, pepsin, enzymes and bile acids. It also accumulates epidermal growth factor in the defect zone, reduces the activity of pepsinogen and pepsin.
Pharmacokinetics
What kinetic properties are inherent in Novobismol tablets? Instructions for use (the price of the medicine is indicated below) states that bismuth tripotassium dicitrate is almost not absorbed from the digestive tract. Although in some cases, a small amount of this substance can still enter the systemic circulation.
The medication is excreted mainly with feces. A small portion of the bismuth entering the plasma is excreted via the kidneys.
Indications
What diseases does the drug Novobismol treat? Reviews of experts say that this medicine is effective for peptic ulcer of the gastrointestinal tract in the acute phase (including those associated with Helicobacter pylori).
Also, the medication in question is prescribed for chronic gastritis and gastroduodenitis in the acute phase, irritable bowel syndrome, which occurs mainly with signs of diarrhea, functional dyspepsia, not associated with organic gastrointestinal diseases.
Contraindications
What conditions of the patient are forbidden to use the drug "Novobismol"? Instructions for use suggest that this drug should not be prescribed for severe renal impairment, during breastfeeding, with increased sensitivity to bismuth tripotassium dicitrate and during pregnancy.
Dosage and route of administration
How should I use the drug "Novobismol"? Instructions for use informs that this tool is prescribed not only for adults, but also for small patients, starting from 4 years.
Tablets are taken orally 2-4 times a day exactly 30 minutes before eating. The dosage of the medicine is selected individually. As a rule, it depends on the age of the patient.
The course of treatment with this drug is 4-8 weeks. In the next 8 weeks, it is strictly forbidden to take drugs that also contain bismuth.
To eliminate Helicobacter Pylori tablets "Novobismol" it is advisable to use in combination with antibacterial drugs with anti-Helicobacter pylori activity.
Side effects
Does the drug "Novobismol" have side effects? Reviews of patients say that after taking these pills, they often have undesirable effects. From the digestive tract, the patient develops transient effects such as nausea, frequent stools, vomiting, or constipation. Dermatological reactions in the form of skin rash and itching may also occur.
With prolonged use, especially at high dosages, the patient may develop encephalopathy from the central nervous system, which is associated with the accumulation of bismuth in the central nervous system.
Co-administration of the drug with food
When combining the drug with other drugs, as well as with food and liquids, including antacids, milk, fruits and fruit juices, the effectiveness of bismuth tripotassium dicitrate can change for the worse. Therefore, tablets should be taken strictly half an hour before a meal, liquid or other drugs.
Special recommendations
It is strictly forbidden to take the drug "Novobismol" for more than 2 consecutive months.
During therapy, it is highly recommended not to exceed the recommended daily dosages for adults and young children.
At the end of the course of treatment, the concentration of the active component in the blood plasma usually does not exceed 5-60 ΞΌg / l, and intoxication is observed only at 100 ΞΌg / l or more.
Against the background of the use of the agent in question, stool is stained in a dark color. In rare cases, a slight darkening of the tongue is noted.
The drug "Novobismol": analogues and cost
Structural analogues of this tool are: βDe Nolβ and βVentrisolβ. Similar drugs in the pharmacological group include: Ankrusal, Alsural, Venter, Kaopektat, Rebamipid Macleods, etc.
How much is the drug "Novobismol"? The price of this medicine varies between 550-600 rubles for 112 tablets.
Consumer Reviews
Most patients who use the drug in question respond positively about it. They claim that this medication has contributed to the rapid elimination of peptic ulcer and complete recovery. However, some patients note that after taking this remedy, they immediately had side effects, in connection with which they were forced to stop treatment.