In recent years, many new drugs have appeared that help in the treatment of brain lesions and disorders. Among these funds and “Cerebrolysin” - a nootropic drug, presented in the form of a solution for injection. The solution has neurotrophic properties, so Cerebrolysin is administered intravenously for strokes, dementia, depression, and hearing loss. The complex action drug has a positive effect on the state of the nerve tissue of the brain. The effect of the solution can be compared with the natural process of neuron growth.
Composition and form of release
What does the detailed instruction for Cerebrolysin say? Intravenously, the drug can be administered due to its properties. The medicine is presented in the form of a clear amber-colored liquid. Its main substance is a cerebrolysin concentrate - a complex of peptides obtained from the pig’s brain. 1 ml of the solution contains 215.2 mg of the main component.
In addition, it contains additional substances: sodium hydroxide and water for injection.
The drug is sold in ampoules of 1, 2, 5, 10 and 20 ml of Cerebrolysin. The drug can be administered intravenously, regardless of the volume of the vials. Also release the drug in 30 ml vials.
Properties of the solution "Cerebrolysin"
The solution "Cerebrolysin" is considered a stimulant of neurometabolic processes. The main component - deproteinized hydrolyzate obtained from the brain of pigs - activates the processes of differentiation of cells, improves the state of the cells of the nervous system and stimulates the protective mechanism.
Animal studies have shown that the biologically active peptides and amino acids contained in the drug positively affect neuronal and synaptic plasticity, which ultimately improves brain function.
After research on models with cerebral cerebral ischemia, it was possible to establish that after the use of “Cerebrolysin” intravenously it is possible:
- reduce the consequences of a heart attack;
- prevent the extensive development of edema;
- normalize microcirculation;
- stabilize neurological and cognitive impairment;
- increase survival rate.
After research on models with Alzheimer's disease, it was possible to prove that the drug has a direct effect on neurons, helps to increase the number of molecules that are responsible for transporting glucose through the blood-brain barrier, and as a result, critical energy deficiency is compensated.
After analyzing the encephalograms of healthy people and patients with vascular dementia, it was possible to establish that after the administration of “Cerebrolysin” intravenously (the instructions for use confirm this):
- increased neuronal activity;
- cerebral function improves;
- the ability to independently service and perform everyday tasks increases, as a result of which the patient does not need additional help.
The injection solution has neurotrophic activity, which ultimately helps to reduce or even completely stop neurodegenerative processes.
During the studies, it was possible to find out that with the introduction of Cerebrolysin, antibodies are not formed intravenously and the anaphylactic reaction does not develop. It does not affect the immune system, does not stimulate histamine receptors and erythrocyte hemagglutination.
Due to the fact that the proteolytic peptide fraction obtained from the pig’s brain includes short peptides similar to those produced by the human body, an accurate pharmacokinetic analysis is not possible.
When is Cerebrolysin used?
According to the instructions for use of Cerebrolysin, it becomes intravenous that the drug is recommended for use in psychiatric and neurological disorders, as well as psychoherontological and neuropediatric diseases, which are accompanied by intellectual and cognitive impairment:
- antidepressant resistant depression;
- injuries affecting the brain and back;
- dementia;
- vascular and senile dementia;
- stroke;
- Alzheimer's disease;
- mental retardation of children;
- chronic cerebrovascular insufficiency;
- hyperactivity of children;
- attention deficit.
Many experts have long been using the drug to treat many diseases. And many of them know exactly the answer to the question, which is better: “Cerebrolysin” intravenously or intramuscularly? Of course, intravenous injections give a faster and more stable result.
How to enter "Cerebrolysin"?
During the preparation of the solution for injection, it is necessary to strictly adhere to the instructions. The effectiveness of treatment depends on the correct method of administration and dose.
In the first days of use, it is recommended to do 2-3 injections per week, and then gradually it is necessary to switch to daily injections. Therapy is best done in courses of 10 or 20 days until the patient is fully recovered or his condition changes dramatically.
During the administration of Cerebrolysin, it is recommended to take 5-10 ml of the solution in a pure form intravenously by stream. If it is necessary to administer large doses, then prepare a solution for slow infusion, and immediately apply after preparation. With intramuscular injection, a solution of 5 ml or more is administered.
After dilution, the drug is active for no more than a day, but if stored in a dark place at room temperature. But in order for the medicine to give the maximum effect, it is better to introduce it immediately after preparation.
Do I need to breed Cerebrolysin? The drug is administered intravenously only in a diluted state. To get a volume of 100 ml, it is diluted with:
- 5% glucose solution;
- NaCl;
- ringer's solution.
They collect the product just before they make the injection.
How to administer the drug intravenously and in what doses?
To neutralize the negative consequences that often occur after an injury to the spinal cord and brain, it is necessary to undergo treatment with Cerebrolysin. Instructions for the use of injections intravenously for adults will tell in detail how to administer the drug and at what dosage.
Apply the drug parenterally. The dosage and course of treatment is selected individually for each patient, depending on the nature and severity of the disease. The patient's age and associated pathologies are also taken into account. You can enter the drug once in 50 ml, but still experts prefer to prescribe a course of injections. The course of treatment can be 10-20 days.
In acute conditions, such as ischemic stroke, traumatic brain injury, complications after neurosurgical operations, the drug is administered in 10-50 ml.
For brain injuries and a residual period of stroke, the dosage is selected depending on the severity of the condition and is 5-50 ml.
For depression and psycho-organic syndrome, a drug of 5-30 ml is administered.
For patients with Alzheimer's disease and dementia of vascular origin, the dose can be from 5 to 30 ml per day.
In the treatment of children with injuries of the spinal cord and brain, the dose is calculated depending on body weight - 0.1-0.2 ml / kg.
To increase the effectiveness of treatment, some patients are recommended to undergo repeated courses. There may be several and all in order to significantly improve the patient's condition. After completing the first course, the frequency of injections can be reduced to 2-3 times a week.
“Cerebrolysin” is administered parenterally in the form of intramuscular injections of 5 ml or intravenous 10. If the dosage is increased more than 10 ml, then it is better to administer the drug by slow intravenous infusion, pre-dilute with standard solutions. The duration of maintenance can be from 15 to 60 minutes.
Side effects
In most patients, after passing the course of injections with Cerebrolysin, no adverse effects are observed intravenously or intramuscularly, but in rare cases, negative reactions still occur. Among them:
- depressive states;
- causeless pain in the chest;
- dizziness;
- drowsiness;
- loss of appetite.
In addition, some patients complain of other side effects:
- fast fatiguability;
- dyspnea;
- hypertension
- hyperventilation syndrome of the lungs.
Symptoms may be much less common:
- chills;
- high level of convulsive activity;
- dyspepsia;
- angioedema;
- seizures of epilepsy;
- allergic manifestations;
- bowel disorders;
- discomfort in the neck, back, arms and legs.
Instructions for use for injections of "Cerebrolysin" intravenously for adults tells that the drug can be used to treat elderly patients. That is why undesirable manifestations in elderly people may not be related to the course of treatment.
Most of the side effects develop due to pathological changes in the body, which has been proven by numerous studies. Many reactions are equally often manifested both during the injection of the drug, and with the introduction of a placebo. These include: tremors, lethargy, pressure surges, shortness of breath, indigestion.
When is the drug contraindicated?
If Cerebrolysin is prescribed (intravenous injections) - instructions for use, reviews confirm this - it is not recommended for people with special sensitivity to the components that make up it. Experts do not recommend administering the drug to patients with severe impairment of renal failure or epilepsy.
Cases of overdose during treatment with Cerebrolysin injections were not detected.
The use of "Cerebrolysin" in the treatment of children
Young children, like adults, get brain injuries that require proper treatment. They can happen during childbirth (such injuries are called perinatal), or during a fall on something solid. Traumatic brain injuries are considered quite serious and can lead to irreversible consequences if treatment is not started in a timely manner.
Traumatic brain injuries can result in the death of cells in the brain, which ultimately provokes the development of mental retardation, a slowdown in physical and mental development, distracted attention and hyperactivity. In order to save the child from such consequences, it is necessary to undergo therapy with Cerebrolysin injections intravenously, the instructions for use describe in detail how and when to apply. The drug helps the brain to restore its functions faster.
Due to the fact that the drug has such functions as neuroprotective, metabolic and neuroplastic regulation, we can say for sure that it restores nerve cells and protects against free radicals. That is why this tool can be considered the best in the treatment of childhood head injuries. It is necessary for the treatment of children with impaired blood flow in brain tissues, which lead to developmental delay.
But you can’t only prescribe an injection course on your own, only the doctor should do this and choose the right dosage in each individual case.
Interaction with other drugs
Before starting therapy, it is important to read the instructions, because it contains the main warning - the introduction of "Cerebrolysin" intravenously and intramuscularly in the same syringe with other means is unacceptable.
Also, the drug is allowed to be simultaneously administered into the body with vitamins and stimulants of cardiac blood flow. But here only in one syringe two medicines are not mixed.
You can not mix in one solution "Cerebrolysin" and balanced solutions of amino acids.
The tool is incompatible with solutions in which the pH is in the range of 5.0-8.0 or with those in which lipids are included.
If “Cerebrolysin”, antidepressants or MAO inhibitors are used at the same time, this combination enhances the effect of each of the drugs. In these cases, it is simply necessary to reduce the dosage.
"Cerebrolysin" is incompatible with drugs that have an effect on the level of hydrogen index.
special instructions
Before you enter "Cerebrolysin" intravenously or intramuscularly, it is necessary to find out in the instructions about its interaction with other drugs.
You can use only a clear solution without sediment and other impurities. After opening the vial, use it immediately, do not store after opening.
If the drug is administered too quickly, then fever, sweating and dizziness may be felt, which is why this should be done as slowly as possible.
During pregnancy, it is not recommended to use "Cerebrolysin", but if suddenly there is no other alternative, then its introduction is allowed, but only under the constant supervision of a doctor. During breastfeeding for the duration of therapy, it is better to temporarily suspend feeding.
Analogs
If Cerebrolysin injections are administered intravenously or intramuscularly, they help to solve many serious problems affecting the back and brain. But the drug is not suitable for all patients, so you have to look for an analogue. In pharmacies, you can find substitutes for the drug, which are also available in the form of a solution in ampoules or vials. According to experts, good substitutes can be considered:
1. “Nootropil” is another drug that is part of the group of nootropics, which regulates metabolic processes, normalizes blood flow in the brain. This drug has sedative and psychostimulating properties. The active component of the drug is piracetam, often used in psychiatry, narcology and neurology. The medicine is available in the form of tablets, injection and capsules. This drug is not recommended for hemorrhagic stroke.
2. "Cerebrocurin." This drug, based on peptide modulators, helps improve brain function. During therapy, a nootropic and anabolic effect is manifested. This unique tool helps to form a specific protection of liver cells from negative effects. The drug is recommended for use in motor aphasia, neurotic syndrome. Available in the form of a solution for injection. This tool is widely used by ophthalmologists. It is not recommended for the treatment of women during the period of bearing a child and breastfeeding.
3. "Cerebrolysate" is another effective agent with a nootropic effect. Thanks to the use of the drug, the metabolism inside the brain cells improves, their resistance to hypoxia increases, and the neurological deficit is significantly reduced. The main substance of the drug is cattle brain hydrolyzate. It is recommended to use in the treatment of neuropathy, cerebral ischemia, cerebral palsy. Available in the form of a solution for injection. After application, an increase in the bioelectroactivity of the brain is observed. During treatment, the patient may have an increase in blood pressure.
Only an expert should select an analogue, taking into account the peculiarities of the course of the patient’s illness and related ailments.
Which is better: Cerebrolysin, Actovegin, Mexidol or Cortexin?
The instruction recommends the use of “Cerebrolysin” intravenously and intramuscularly for patients with dementia, with developmental delay in children, as well as to eliminate the symptoms of a stroke.
Cortexin is a good analogue of Cerebrolysin, but only the drug is presented in the form of a powder, from which a solution for injection is prepared. Consists of peptides that have been extracted from the brain of cattle.
Actovegin is considered a biogenic stimulant, which is actively used during the treatment of ischemic stroke, in case of blood flow disorders in the brain. The preparation contains an extract from the blood of young cows. The tool is actively used in the CIS countries, but in America and Europe it is prohibited.
"Mexidol" is actively used to treat acute and chronic forms of cerebral circulation, during major changes caused by atherosclerosis, for the treatment of vegetative-vascular dystonia. The drug has antioxidant and antihypoxic effects.
Despite the fact that, by their properties, all these drugs can be used in the treatment of diseases associated with impaired brain functionality, they cannot be used without the recommendation of a specialist. "Cerebrolysin" intravenously will bring the maximum effect only if the dose is correctly selected and the treatment course is fully sustained.
Reviews of patients and specialists
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