Pain is one of the physiological phenomena that accompany a person throughout life. It can be the result of bruises and injuries, spasms of muscles and blood vessels, irritation of nerve endings, and a dozen different causes. A lot of medications help a modern person fight pain. One such remedy is NEXT tablets, reviews of which in most cases are only positive.
Advertising positions the drug as one of the most effective in the fight against any kind of pain. What is its feature? How to take these pills? Instructions for use can tell about all this.
Description of the drug, composition
NEXT painkillers are a drug containing two active active ingredients at once: ibuprofen and paracetamol in the amount of 400 and 200 mg, respectively. The tablets are oval in shape and are coated with a red enteric film membrane. On one side there is a transverse risk. At the fracture of the tablet, a white or almost white core is visible. Tablets do not have a pronounced taste, but they must be taken without chewing.
In addition to the active components, the composition of the drug "Next" instructions for use and mentions excipients. These are microcrystalline cellulose, croscamellose sodium, magnesium stearate, aerosil and calcium hydrogen phosphate. These elements form the core of the NEXT tablet core. The composition of the shell includes dyes, polyethylene glycol, polysorbate, polyvinyl alcohol, titanium dioxide, hyprolose and talc.
The Next medicine is packaged in branded cardboard boxes with the logo of the manufacturer. Each box can contain 1 or 2 blister packs with 2, 6, 10, or 12 tablets.
Pharmacological properties of the drug
"Next" (tablets), the instruction refers to non-steroidal anti-inflammatory drugs. This is due to the fact that one of the active components (ibuprofen) refers to this particular group of drugs. Paracetamol, in turn, is an antipyretic analgesic. In a word, "Next" application instruction relates to combination means that can not only relieve pain of almost any origin, but also help reduce body temperature. Also, the drug has a pronounced anti-inflammatory effect.
Let us consider in more detail the pharmacological properties of each component of the drug. Paracetamol affects the synthesis of cyclooxygenase and receptor susceptibility to the effects of this compound. This active substance acts to a greater extent on the pain receptors in the central nervous system. Ibuprofen also has an inhibitory effect on cyclooxygenase by a non-selective method, due to which it has the property of regulating the synthesis of prostaglandins, that is, it effectively affects pain receptors in the peripheral parts of the body.
After taking the "Next" tablets, their effect becomes noticeable after 25-45 minutes. The half-life of the active components is 1-4 hours from the time of taking the medicine.
Indications for use
"Next" (tablets) instructions for use recommends taking as an anesthetic in the following cases:
- With a headache of various etiologies, including migraines, pain caused by excessive contraction of the muscles of the head and shoulder girdle.
- With febrile conditions caused by inflammatory diseases of an infectious and viral origin in the body.
- With spasms of smooth muscles of the internal organs, including algodismenorrhea, intestinal pain, etc.
- For back pain caused by inflammation of muscle fibers (myalgia).
- With joint pain caused by degenerative changes in the musculoskeletal system.
- With neuralgia.
- With toothache.
- With fractures, bruises and other injuries, as well as during the recovery period in the postoperative and post-traumatic period.
In situations where the pain resumes within a few days, you may need to see a doctor. Sometimes a seemingly banal or mild pain can hide a serious illness. Long-term use of the painkiller "Next" will not only smear the picture, but will inevitably lead to malfunctioning of many internal organs.
Contraindications
Instructions for use contain information about contraindications for the use of the drug "Next". Tablets should not be taken for those who have intolerance or hypersensitivity to their constituent components. In addition, there is a fairly extensive list of conditions under which the use of this drug requires caution. One of the contraindications for taking the Next medicine is children's age (up to 12 years). In addition, special attention should be paid to the weight of the patient when prescribing the drug: for individuals whose body weight has not reached 40 kg, you may need to abandon its use.
The Next drug is unsafe for newborns, therefore, nursing mothers should refuse to breast-feed while they are taking until the components of the drug are completely eliminated from the body. The third trimester of pregnancy is also a contraindication to taking these pills.
There are a number of ailments in which it is not recommended to take the drug "Next" (tablets). In this case, the instruction mentions the following diseases:
- erosive and ulcerative lesions of the gastrointestinal mucosa in the acute stage, including bleeding, gastritis, enteritis and colitis;
- severe cardiac, renal and hepatic insufficiency;
- hyperkalemia
- diseases of the hematopoietic system and circulatory system, including hemophilia and hemorrhagic diathesis;
- bronchial asthma and recurrent polyposis of the nasal cavity and sinuses, combined with intolerance to NSAIDs;
- recovery period after coronary artery bypass grafting;
- liver diseases, including alcoholic or viral hepatitis, cirrhosis;
- nephrotic syndrome;
- diabetes.
Before using the medicine, you must make sure that there are no contraindications. To do this, it’s enough to consult a doctor who can examine your medical history for any allergic reactions to medications, as well as identify diseases in which the use of this drug may be dangerous.
Information about overdose and side effects
Regarding the side effects that may appear while taking the Next drug, the instructions for use contain detailed information that you can familiarize yourself with in the table below.
Side effects | Possible reactions |
The cardiovascular system | Heart rhythm failures, in particular tachycardia, heart failure and increased blood pressure. |
Respiratory system | Bronchospasm, shortness of breath and shortness of breath, allergic rhinitis. |
Nervous system | Anxiety, depression, dizziness and headaches, insomnia or drowsiness. |
Gastrointestinal tract | Pain in the epigastric region, indigestion (diarrhea, constipation, nausea, vomiting, belching and increased gas formation), aphthous stomatitis, pancreatitis. |
Urinary organs | Polyuria, cystitis, nephrotic syndrome and renal failure. |
Hematopoietic organs | Leukopenia, anemia, thrombocytopenia and agranulocytosis. |
Sensory organs | Noises or ringing in the ears, diplopia, dry eyes, irritation. |
Skin integument | Rashes of an allergic nature, swelling, angioedema, Stevens-Jones syndrome, Lyell's syndrome. |
With prolonged use of the drug "Next" tablets can provoke the appearance of all the above adverse reactions in a more complex form. In addition, their nephrotoxic and hematotoxic effects on the body are enhanced. In this regard, it is not recommended to use this drug for longer than 3-5 days in a row.
Recommendations for the dosage of tablets "Next": instructions
According to the instructions for use, drinking Next tablets is better after eating. In this case, they do not have a pronounced effect on the mucous membranes of the digestive tract. The daily dosage for adult patients should not exceed 3 tablets (one for each dose). For children over the age of 12 years, the daily dose is slightly lower and is 2 tablets.
The duration of therapy with the use of the drug "Next" depends on whether it is taken as an anesthetic or as an antipyretic. In the first case, the duration of admission is a maximum of 3 days, in the second - no more than 5 days. If the patient needs to continue taking the Next drug, the instructions for use advise you to consult a specialist.
special instructions
When taking the medicine, it is necessary to ensure that the patient does not use other drugs that contain NSAIDs and paracetamol, as this can lead to an overdose. When extending the course of treatment with NEXT tablets, it is necessary to monitor and, if possible, monitor the peripheral blood laboratory parameters and the state of the liver and kidneys.
Within a day after taking the drug, laboratory indicators for blood glucose and uric acid may be distorted. Before taking a blood sample for analysis, tell your doctor or laboratory assistant that you have taken this medicine. Also, NEXT tablets can distort the picture in the study of blood (or plasma) on 17-corticosteroids. Before undergoing this examination, it is necessary to cancel the drug two days before the collection of materials.
Patients taking NEXT are not recommended to drink alcoholic beverages. In addition, there is a likelihood of injury due to adverse reactions from the nervous system. Therefore, during treatment with this remedy, it is worth abandoning those activities that require an increased concentration of attention and a quick reaction.
Drug interaction
Since the Next analgesic tablets contain two active components at once, the list of its drug interactions includes several more items than other, single-component drugs. Some drugs reduce the toxic effects of the components, while others enhance. It is important for each patient to know about the adverse combinations of drugs with Next tablets to avoid severe consequences for the body.
So, let's move on to the main question: with which drugs are NEXT tablets better not to take? First of all, it is worth mentioning a variety of tinctures containing ethyl alcohol. The fact is that ibuprofen in combination with alcohol is much more likely to cause erosion and ulcers in the mucosa of the gastrointestinal tract. The combination of NEXT tablets with glucocorticosteroid drugs has the same effect on the body. Paracetamol also reacts with alcohol-containing drinks and medicines. In this case, the patient may develop acute pancreatitis.
Preparations containing barbiturates and tricyclic antidepressants can not only reduce the absorption of paracetamol, but also cause severe poisoning. It is especially dangerous to take such substances in conjunction with high doses of Next tablets.
Both active substances (paracetamol and ibuprofen) affect the absorption and effectiveness of anticoagulants in a big way. Before using an anesthetic drug and drugs that reduce blood coagulation, you must consult a doctor regarding dose adjustment of drugs. The same action will be required while taking painkillers and insulin-containing drugs and vasodilators.
Storage and distribution conditions from pharmacies
NEXT tablets, the price of which is not too high, are sold over-the-counter. However, this does not mean at all that everyone can take them without exception. As mentioned above, the feasibility of using tablets is determined by the absence or presence of contraindications in the patient.
Storage of the drug should be carried out according to the rules generally accepted for all medicines. Tablets should not be exposed to direct sunlight, too high or low temperatures. An ideal storage environment is a dark, dry, ventilated room with a temperature of 17-25 degrees. It is necessary to provide that the drug is dangerous for children. In this regard, it is not recommended to leave the tablets in their access area.
The shelf life of the drug is limited to a period of two years. After this period, they should not be consumed.
How much are NEXT tablets: price
The drug can be found in almost any pharmacy. Its cost depends on how many tablets are contained in the package. For example, 6 tablets cost from 90 to 126 rubles. Larger packages cost from 145 to 180 rubles. Moreover, any contains the drug in a single dosage.
Conclusion
We talked about everything related to the drug "Next" (tablets). Instructions, price, pharmacological properties, indications for use, etc. were described in detail in this review. In conclusion, I would like to note the following: still try to see a doctor as necessary. Do not self-medicate!