The pharmaceutical preparation “Papazol” refers to the instructions for use in the clinical and pharmacological groups of antihypertensive drugs, antispasmodics and myotropic antispasmodics. Thus, this medication produces an antispasmodic, hypotensive and vasodilating effect.
The drug is available in the form of tablets (white or grayish, slight inclusions are allowed), distributed in cardboard packs of ten pieces each.
The composition of the drug is represented by papaverine (0.03 grams in each tablet) and imidazole derivative - bendazole (a similar amount - 0.03 g / tab.). The first component is able to block intracellular phosphodiesterase and creatine phosphokinase of vascular smooth muscles, cause the accumulation of cyclic adenosine monophosphate, and exert a vasodilator effect. Bendazole affects the smooth muscles of the vascular walls due to the effect on the imidazole receptors. This substance also contributes to an active reduction in blood pressure and the content of free calcium in smooth muscles.
An auxiliary component is potato starch, calcium stearate, milk sugar.
Medication "Papazol". Instructions for use and dosage recommendations
The pharmaceutical agent in question is taken orally. Adult patients are shown one or two tablets up to three times a day.
It is noted that with the parallel use of this drug and antispasmodics, sedatives, diuretics, tricyclic antidepressants, procainamide, reserpine or quinidine, an increase in the severity of the hypotensive effect is not excluded. It was also found that adsorbing, enveloping and astringent medicines lower the level of absorption in the gastrointestinal tract of the drug "Papazol".
The instruction notes that when it is used, undesirable effects such as nausea and irregular stools may occur. Also recorded is a malfunction of the central nervous system, such as dizziness. In some patients, arrhythmia, decreased myocardial contractility, AV block, allergic reactions, increased sweating were observed.
The drug “Papazol” instructs the user to use for the treatment of labile arterial hypertension, spasms of cerebral vessels and arteries (peripheral), smooth muscle spasms of internal organs (including stomach ulcers, duodenal ulcer, intestinal colic, cholecystitis, spastic colitis), residual effects polio and paralysis of the facial nerves (peripheral). The medication is used both separately and as part of a combination treatment.
The considered drug is not prescribed if the patient suffers from violations of AV conduction, epileptic syndrome, bronchial obstructive syndrome, hypersensitivity. In addition, the medication is contraindicated in children under the age of twelve.
The drug Papazol-UBF with special care (and in minimal doses) is prescribed to patients with reduced intestinal motility, traumatic brain injury, liver and / or renal failure, hypothyroidism, adrenal insufficiency, prostatic hyperplasia, as well as during the period of expectation of a child and breastfeeding (since the safety of its use during this period has not been proven, lactation is suspended during treatment).
The drug "Papazol", reviews of which are mostly positive, is suitable for use within five years from the date of manufacture.
The medicine is approved for sale without a doctor’s prescription.