Choline alfoscerate is an active drug component that is found in many medical products. You will learn about the properties of this substance, why it is indicated, and which preparations are included in the materials of this article.
Where is choline alfoscerate contained?
Instructions for the use of those medicines that include the presented component are available in each package along with the medicine.
The most famous and widely used medicines with such an active substance are the following drugs:
- "Gleazer."
- "Gliatilin."
- Cerepro.
- "Glycerylphosphorylcholine hydrate."
- "Cereton".
- Cholitilin, etc.
Existing Release Forms
Preparations with such an active substance as choline alfoscerate, reviews of which are more positive, are available in the form of capsules and injectable solutions. As a rule, they go on sale in cardboard packaging or in small plastic jars.
pharmachologic effect
Choline alfoscerate stimulates central cholinergic receptors. Entering the human body, such an active substance breaks down into choline and glycerophosphate.
The presented drug component provides a complete formation of phosphatidylcholine. In addition, it significantly improves the plasticity and function of receptors, neuronal membranes, and also activates cerebral blood flow, stimulating cholinergic neurotransmission, nervous system metabolism, and the reticular formation.
It should also be noted that choline alfoscerate significantly improves concentration, the ability to remember and further reproduce information, significantly improves mood, mental activity, and also eliminates negative emotions, including apathy, and optimizes cognitive reactions.
In case of traumatic brain injuries, this substance normalizes blood flow in the affected area and the bioelectric activity of the brain. In addition, this component of drugs helps to suppress neurological symptoms.
Pharmacokinetics
After oral administration, the absorption of this component is about 88%. Choline alfoscerate passes quite easily through the blood-brain barrier. It should also be noted that this substance accumulates in the brain, lungs and liver. Its level in the central nervous system reaches approximately 45% of the content in blood plasma.
About 86% of choline alfoscerate is excreted through the lungs in the form of carbon dioxide, and the rest through the kidneys and intestines (approximately 14%). This substance does not have teratogenic and mutagenic effects, and also does not affect the human reproductive system .
Indications for use
Why is choline alfoscerate prescribed to the patient? Analogues of such a tool and the drug itself are used for:
- acute period of traumatic brain injury;
- discirculatory encephalopathy;
- dementia (Alzheimer's type, senile or mixed forms);
- Huntington's chorea ;
- during the recovery period of ischemic stroke;
- memory impairment;
- functional disorders of the central nervous system;
- confusion of consciousness;
- decreased initiative, concentration and motivation;
- disorientation;
- senile pseudomelancholy.
Choline alfoscerate: instructions
Take medications (capsules) that contain such an active substance, should be inside just before the meal. As a rule, such drugs are prescribed by doctors in one or another dosage, depending on the existing disease. But, according to the attached instructions, choline alfoscerate must be taken three times a day at 400 mg. The duration of such therapy is usually about 4-6 months.
If the patient has an acute condition, then the presented component is slowly administered intravenously or intramuscularly. In this case, the dosage of the injection solution is 1 g per day.
If, after using the drug, the patient develops severe nausea, it is advisable to reduce the dose by 1.5 or 2 times.
Contraindications
Using drugs that contain the presented component is not recommended for hypersensitivity to it. In addition, choline alfoscerate is strictly forbidden to use by pregnant women and nursing mothers.
Feasible side effects
According to reviews, medicines with the active substance choline alfoscerate almost never cause any side effects. However, occasionally patients may experience a strong or moderate feeling of nausea. As mentioned above, in such cases, you should either reduce the dosage, or completely stop taking the drug.
Drug overdose
If the medicinal substance of choline alfoscerate is uncontrolled, an overdose may occur in the patient. As a rule, the patient in such situations feels a strong feeling of nausea, which ends with vomiting, and allergic reactions (rash, itching of the skin, etc.) can also occur.
Drug interaction
To date, no interaction of this substance with other medicinal components has been identified.
The price of drugs
The cost of drugs that contain the active substance of choline alfoscerate varies significantly. Consider the price category of each drug in more detail:
- The medication "Gleazer." For three ampoules of this drug you will have to pay about 260-270 Russian rubles.
- The drug "Gliatilin." The price of 14 capsules of such a medicine is about 740-760 rubles. If you need to purchase the medicine in ampoules, then for three pieces you will be asked about 570 rubles.
- The medicine "Cerepro". Such a drug in capsules is sold for 500 rubles (14 units). If the drug is required in ampoules, then for three pieces you will have to pay about 400 rubles.
- Means "Tsereton". Ampoules of such a drug can be purchased for 280-300 rubles (3 pieces).
- Medication "Cholitilin." This tool (ampoules) is sold in pharmacy chains for 370-380 rubles (3 jokes).