"Propitsil": reviews, indications and contraindications, purpose, form of release, particularities of administration, dosage and composition

In the article, we consider the instructions for use and reviews of "Propitsil".

This medication, being a modern drug, shows a high degree of effectiveness in the treatment of a number of pathological conditions of the thyroid gland. The drug is able to actively inhibit the process of excessive production of thyroid hormones, as well as reduce their negative effects on the background of symptoms of toxic goiter, autoimmune thyroiditis and hyperthyroidism.

"Propitsil" is often prescribed as a preparatory stage before surgery on the thyroid gland. The drug is considered potent, it has a powerful antithyroid effect on the body and requires the appointment of a doctor, as well as a clear schedule of administration and duration of the course. An important step in the treatment with “Propitsil” is the regular monitoring of clinical blood parameters, as well as checking the balance of hormones in the body. Such control will help to avoid intoxication of the body against an overdose.

The instructions attached to the drug contain detailed information about its properties, composition, adverse reactions, indications and contraindications. Reviews about the "propitsil" are found in large numbers.

Structure

Propylthiouracil acts as an active component. This substance is an antithyroid drug, the concentration of which in one tablet is 50 mg. In addition, the composition of the tablets is supplemented with auxiliary components, including two varieties of corn starch, lactose monohydrate, magnesium stearate, povidone, colloidal silicon dioxide.

The properties

Propylthiouracil acts on the body as an inhibitor of an enzyme called thyroid peroxidase. Thus, it is possible to prevent the conversion of ionized iodine and its transition into the active phase. In addition, the active component of the drug prevents the conversion of peripheral tetraiodothyronine to a hormone known as triiodothyronine.

"Propitsil" has a pronounced thyrostatic effect. During treatment with the drug, the intensity of the manifestation decreases, or the symptoms of thyrotoxicosis completely disappear. In some cases, the size of the thyroid gland may increase as a response to exposure to propylthiouracil.

The active component of the drug is absorbed in the digestive tract, excretion of metabolites occurs during the day. The drug is almost completely excreted in the urine unchanged.

The drug is in the form of tablets for oral administration of white color. Available in packs of 20, 50 and 100 tablets.

Each pack has instructions for use with Propitsil. Price and reviews will be presented at the end of the article.

Indications

Preparations based on propylthiouracil as an active component are prescribed for the treatment of the following pathological processes in the endocrine system:

1. Thyroid adenoma, provoked by intoxication.
2. Diffuse nodular goiter due to intoxication.

“Propitsil” is included in the preparatory phase before the following medical procedures:

1. Radioiodine therapy.
2. Thyroid resection - both partial and complete.
   

Contraindications

The drug is not prescribed for a number of reasons, including the following pathological processes:

1. Hepatitis.
2. Leukopenia
3. Hypersensitivity to the components that make up the drug.
4. Decreased thyroid function.
5. Severe liver failure.
6. Agranulocytosis.
7. Severe damage to the renal parenchyma.
8. Lactation.
9. Pregnancy.
10. Cirrhosis of the liver.

“Propitsil” as an antithyroid drug is used under strict medical supervision, as well as with caution against the background of increased activity of transaminases or with pathological disorders in the blood. If a patient suffered severe liver damage and agranulocytosis was recorded against the background of a propicil course of therapy, then a second course of treatment with a drug based on a similar active component is prohibited.

Despite contraindications, judging by the reviews, “Propitsil” is safe during pregnancy.

During the period of bearing a child, it is allowed to take minimal dosages of the drug according to vital indicators, for example, against the background of severe thyrotoxicosis. The use of the drug during pregnancy should be appropriate for the condition of the woman, and the doctor must assess the possible risks before prescribing such potent drugs.

Instruction manual

The tablet should be swallowed whole, without chewing, washed down with a sufficient amount of water at room temperature. To maintain the thyreostatic effect of the drug during the day, the drug is taken up to four times a day at equal intervals. Reviews about the propitsil tablets are mostly positive.

If the purpose of admission is maintenance therapy, the daily dosage can be reduced up to a single dose. In childhood, the daily dosage is necessarily divided into three doses. In the newborn, the endocrinologist prescribes a drug of 5-10 micrograms per kilogram of body weight of the child.

If the balance of hormones in the body does not return to normal while taking “Propitsil”, then, on the recommendation of a doctor, it is recommended to increase the daily dosage of the drug up to two times. At the age of 6-10 years, the initial daily dosage is 50-150 mg of propylthiouracil. When the hormone balance is normalized, the amount of the drug taken is reduced to one tablet or half a day. Children over 10 years of age are prescribed a similar dosage to adults - 1.5-2 tablets (75-100 mg of the active component).

If we are talking about the treatment of severe thyrotoxicosis, as well as against the background of severe intoxication with hormones, the daily rate of the drug increases and can reach 300-600 mg. At such high concentrations, the daily rate should be divided by 4-6 times.

The course of administration of “Propitsil” and its duration directly depend on the patient’s condition, the balance of thyroid hormones, as well as the intensity of the severity of the clinical picture of the pathological process. In some cases, the duration of administration of "Propitsil" can reach several years.

Before undergoing a course of radioiodine therapy, as well as in preparation for surgery, the frequency of administration of the drug and its duration is determined individually by a specialist.

Adverse reactions

According to reviews of “Propitsil”, with strict observance of the doctor’s instructions regarding the dosage and duration of administration, the drug is well tolerated by patients and does not lead to the development of adverse reactions. However, against the background of increased sensitivity to the components of the drug, changes in the clinical indicators of blood composition are possible, namely the appearance of signs of agranulocytosis. A similar complication is associated with septic complications. Some patients report the following adverse reactions while taking Propitsil:

1. Skin rash.
2. Hives.
3. Arthralgia without severe inflammation of the joints.
4. The appearance of goiter, characteristic of patients in childhood.

Reviews of the side effects of “Propitsil” should be consulted in advance.

Such manifestations of a negative reaction to the drug as:

1. Alopecia.
2. Fever.
3. Edema on the periphery.
4. Thrombocytopenia.
5. Violations of neuromuscular connections.
6. Nausea and vomiting.
7. Periarteritis nodular type.

Overdose

With a significant excess of the dosage of the drug, the probability of proliferation of goiter, as well as thyroid tissue, increases.

Compression of structures located in the mediastinum, that is, in the esophagus and trachea, can lead to difficulty breathing and swallowing, as well as to a deterioration in the general well-being of the patient.

This is confirmed by reviews of the side effects of "Propitsil".

Do not exceed the dosage prescribed by your doctor. Even in the absence of signs of acute poisoning, regular overdoses on the background of intolerance to an individual drug can lead to such serious consequences as hyperthyroidism and goiter. These manifestations are accompanied by negative symptoms of varying severity.

Below are reviews of Propitsil.

Drug cost

As for the cost, it directly depends on the number of tablets in one package. The price category of propylthiouracil-based drugs is considered high and averages 600 rubles for 20 tablets and 970 rubles for 100 tablets in one package.

Reviews

"Propitsil" is considered a potent drug. Some patients who have undergone treatment with this drug note a marked improvement in their condition.

What other reviews about "Propitsil" are found?

The disadvantage of the drug is the need for constant monitoring of clinical blood counts. However, this is a prerequisite for the treatment of the thyroid gland. The advantages of the drug include the possibility of prescribing to children with hyperthyroidism, starting from birth.

The cost of the propitsil treatment course can be quite high, since in some conditions the drug must be taken over a long period of time repeatedly, up to eight times a day. Sometimes treatment can last about two years or even longer, which will entail serious financial losses.

We reviewed the propitsil instructions for use and reviews.