An excellent drug for combating parasites and microbes that live in the human body is the medicine Combiflox. The medication has a wide range of effects. Most often it is used in the presence of mixed infectious pathologies that are bacterial in nature. But for some reason, some patients cannot resort to the help of the original remedy. Naturally, they have a lot of questions. What analogs can I take? Combiflox and its substitutes are equally effective? Let's get it right.
Brief description of the drug "Combiflox"
The drug is an excellent antimicrobial and antiprotozoal agent with antibacterial activity. A combination medicine is prescribed for a variety of infectious diseases.
Its wide range of effects is dictated by the components that make up the drug:
- Ornidazole This substance has antimicrobial and antiprotozoal effects. The component is a 5-nitroimidazole derivative. The substance, entering the human body, has an effect on the DNA of pathogenic microorganisms. As a result, bacteria die. The ingredient actively fights many microorganisms. But it remains insensitive to aerobic.
- Ofloxacin. An antimicrobial substance that is part of the fluoroquinolone group. Its mechanism of action is associated with an effect on DNA gyrase (bacterial enzyme). The component provides destabilization of DNA chains. Such an effect leads to the death of bacteria. The substance has a pronounced bactericidal effect.
The drug is produced in the form of tablets, top coated with a film coating.
Indications for appointment
What is Combiflox medicine from? The medication instruction recommends taking tablets with:
- Mixed bacterial infections provoked by susceptible microorganisms.
- Infectious and inflammatory diseases of the peritoneum, kidneys (pyelonephritis), bile ducts.
- Disorders of the reproductive system and pelvic organs (endometritis, oophoritis, salpingitis, cervicitis, parametritis, colpitis, orchitis, prostatitis, epididymitis).
- Infectious diseases of the urinary tract (urethritis, cystitis).
Contraindications
Before using this drug in therapy, it is necessary to carefully study the limitations of treatment.
"Combiflox" tablets - instructions for use prohibit use by people in the following conditions and pathologies:
- individual hypersensitivity;
- epilepsy;
- age less than 18 years;
- reduced convulsive threshold (triggered by a head injury, strokes, inflammation of the central nervous system);
- pregnancy;
- tendon damage during fluoroquinol therapy;
- lactation period.
special instructions
With high caution, the drug is prescribed to patients suffering from:
- atherosclerosis;
- cerebrovascular accidents;
- renal failure;
- liver diseases;
- organic pathologies of the central nervous system (multiple sclerosis);
- predisposition to convulsive manifestations;
- myasthenia gravis;
- diabetes mellitus;
- heart ailments (heart attack, heart failure, bradycardia);
- various mental disorders in history;
- alcoholism.
Side effects
The medicine can become a source of numerous unpleasant reactions. That is why this medication should be prescribed exclusively by a doctor who will monitor the treatment process. So, what reactions can patients using Combiflox tablets face?
The instruction warns of the possible occurrence of the following side effects:
- Digestive system. Gastralgia, nausea, and vomiting may occur. Sometimes appetite decreases, diarrhea or constipation appears. Patients may experience abdominal pain, flatulence, hepatitis, cholestatic jaundice, pseudomembranous colitis. Many complain of increased dry mouth.
- Nervous system. Therapy may be accompanied by dizziness, high nervousness, insomnia, headache. Sometimes there is tremor, paresthesia or numbness of the limbs, cramps, insecurity in movements. The patient may have nightmares. Some patients manifest phobias, depression, hallucinations. Perhaps the appearance of epileptic seizures, psychotic disorders with a predisposition to suicide.
- Musculoskeletal system. The risk of developing a patient with tendosynovitis, tendonitis, arthralgia, myalgia cannot be ruled out. Sometimes during treatment, pain in the limbs, muscle weakness appear, tendon ruptures are diagnosed.
- The sensory organs. The patient may experience a violation of taste, smell. Sometimes interruptions occur with coordination or hearing. Some patients note a violation of color perception or strangeness in taste.
- The heart system. Periodically, patients suffer from tachycardia. Some note an increase or, conversely, a decrease in pressure. Possible collapse, ventricular arrhythmia. Sometimes there is an extension of the QT interval.
- Allergy. Treatment may be accompanied by the appearance of urticaria, itching, unpleasant skin rash. In some cases, there is the development of allergic pneumonitis, nephritis, angioedema, fever, bronchospasm, eosinophilia. Exudative erythema, epidermal toxic necrolysis, anaphylactic shock, photosensitivity, vasculitis can appear. Women may experience increased itching in the genital area.
- Hematopoietic organs. During therapy, sometimes the development of leukopenia, anemia. Some are faced with thrombocytopenia, agranulocytosis.
- Urinary system. Sometimes patients complain of impaired renal function, dysuria, urinary retention. During treatment, urea concentration may increase, and kidney failure may develop.
In addition to the above unpleasant manifestations, the appearance of:
- intestinal dysbiosis;
- superinfection;
- hypoglycemia;
- vaginitis;
- chest pain
- fatigue;
- nosebleeds;
- intense thirst;
- pharyngitis;
- rhinitis;
- dry cough.
The best analogues
What drugs can replace the original product? The following analogues exist on the pharmacological market: Combiflox
":
- Ashof (solution);
- Danzil (drops);
- Gyro (tablets);
- "Zanocin" (solution, tablets);
- "Dazolik" (tablets);
- Zoflox (solution, tablets);
- "Ornidazole" (tablets);
- Lornizole (pills);
- Ornion (tablets);
- Oflo (pills);
- Ornisid (tablets);
- Ofloxabol (solution);
- Ofloks (tablets);
- “Ofloxacin” (tablets, solution, ointment);
- "Tarivide" (solution);
- "Taricin" (tablets);
- Tiberal (pills);
- "Phloxal" (drops, ointment);
- Uniflox (drops).
The list of drugs that can become an alternative to the original medication is quite extensive. However, you should not choose Combiflox analogues on your own. Before replacing a medication, it is necessary to consult a doctor to avoid the occurrence of extremely negative reactions.
What else can replace the original medicine?
Do you need to find an analogue as close as possible to the medication? Combiflox tablets can be replaced with drugs: Ofloxacin (200 mg) and Ornidazole (500 mg). These drugs are the active ingredients of the original remedy.
These drugs must be taken together. Sometimes they are advised to separate in time. In order to correctly draw up a therapy regimen (if these Combiflox analogues are selected), it is necessary to consult with your doctor.
Patient opinion
How do people respond to treatment with Combiflox? Patient reviews indicate that some unpleasant reactions do appear during therapy. Most often, sick nausea, dizziness. Often patients indicate the appearance of mental disorders, worsening mood.
Doctors explain the occurrence of such reactions by the high concentration of the two strongest antibiotics. At the same time, doctors are in no hurry to prescribe such a strong medication to the patient. As practice shows, the medicine “Combiflox” is resorted to only in situations where the undertaken long-term treatment did not provide positive results.
Can analogues become an effective alternative to the original medication? Unfortunately, in most cases, no. For example, the drug Ofloxacin affects only part of the pathogenic microflora. Therefore, with some diseases, the medicine may be ineffective. This feature is also characteristic of the medicine "Ornidazole".
Conclusion
Only in the right combination, the active substances ofloxacin and ornidazole can effectively save the body from developing serious pathologies. That is why, despite the many negative symptoms that occur during therapy with Combiflox, patients indicate that the original medication really helps.