"Polyoxidonium" (6 or 12 mg) is an immunomodulatory agent. The medication is available in tablet form, in the form of suppositories and powder for the preparation of an injectively injected solution. The tool is intended to increase the resistance of the human body to infections - local, systemic. A key mechanism of effectiveness is a direct effect on phagocytes and killers. Taking the medication allows you to activate the generation of antibodies in the patient's body.
Technical information
On sale there are suppositories "Polyoxidonium". There are two dosage options: 6 mg in one candle and twice as much. Suppositories are intended for rectal, vaginal use. Made in the form of a torpedo, painted in a light shade of yellow. If you sniff, you can feel the faint aroma of cocoa butter. A high-quality product is uniform, if cut, you can see the air rod or the indentation in the form of a funnel - but there may not be such ones. Both options are considered normal. Each candle contains 6 or 12 mg of azoximer bromide. As additional ingredients used are cocoa butter, povidone, mannitol.
On sale there are bottles with "Polyoxidonium" (6 mg, 3 mg, 12 mg). Inside the container is the powder used to prepare the liquid. In this form, the drug is used locally or injected. Powder is a porous mass that has a slight shade of yellow. In addition to the main ingredient, povidone and mannitol are present in the powder. Bottles are made of special glass.
Finally, there is a tablet form. In this embodiment, there is only one dosage - 12 mg of the active ingredient in one capsule. The tablets are white or light yellow. Instances are made in round, flattened cylinders. Chamfer, risk, inscription: βONβ are provided.
Pharmacology
As can be learned from the instructions for use of "Polyoxidonium" (suppositories, tablets, powder), the drug belongs to the class of immunomodulators. The main active ingredient is known for its complex effect. It modulates the immune system, relieves the body of toxic substances, stops the activity of inflammatory foci, has an antioxidant effect. Azoximer bromide increases the resistance of the human body to infectious agents - with local invasion, systemic infection. Under its influence, immune reactions are stabilized in case of insufficiency of immunity of the secondary form, if this is due to infection, burns, trauma. Often, the drug is prescribed for a weakened immune system against a background of malignant disease and complications caused by surgery, the use of chemotherapeutic drugs. Sometimes "Polyoxidonium" is prescribed if a person is faced with a weak immune activity due to the use of steroid, cytostatic drugs.
Instructions for the use of "Polyoxidonium" (suppositories and other forms) indicate a key mechanism for the effectiveness of the drug - the effect on phagocytes, natural killer cells. The drug stimulates the generation of antibodies. Azoximeric bromide activates the production of alpha, gamma interferons. This explains the antiviral reliable effect of the medication. Due to this quality, the tool can be used to prevent SARS, influenza.
Pharmacological features
In the accompanying candles, tablets, ampoules, instructions for the use of "Polyoxidonium" (6 mg, 3 or 12 mg), the presence of the qualities of an antioxidant and detoxifier is specified. These features of the azoximeric compound are due to its specific structure, high molecular qualities, while not correlating with the activity of immunity mechanisms. The active ingredient inhibits soluble poisonous compounds, microscopic particles, cleanses the body of toxins. The tool helps to get rid of metal salts, inhibits peroxidic fat oxidation. Due to its qualities as an antioxidant, chelator, antiradical, and membrane stabilizer, this drug gains a strong anti-inflammatory effect.
It is recommended to use, following the instructions for use, Polyoxidonium (6 mg and other release options), if it is necessary to draw up a comprehensive therapeutic course against a background of cancer. The introduction of the drug in question into such a program reduces the toxic effect of radiation treatment and chemotherapy. For most patients, a standard program without correction is available due to infectious complications and severe side effects. The latter include colitis, cystitis, inhibition of bone marrow activity, stable profuse loose stools, and vomiting.
Pharmacology and effects on immunity
If you turn to the accompanying documentation describing the pharmacological characteristics of the tablets, powder, suppositories "Polyoxidonium" (6 mg and other options), you can find out that the drug shows a reliable effect in the secondary state of weak immunity. The use of the medication improves the result of the use of antibiotics, glucocorticosteroids, bronchodilators. The use of the pharmaceutical product in question helps to reduce the duration of the main treatment and in general to reduce the volumes of the main drugs received by the human body aimed at combating the disease. The duration of remission is increasing.
As noted in the documents accompanying the tablets, lyophilisate, Polyoxidonium suppository (6 mg and other volumes), the active ingredient of this drug is very well perceived by the human body. Not revealed the ability to provoke mutations. There is no teratogenic effect for the embryo. The manufacturer indicates a lack of carcinogenic qualities and the ability to provoke allergies. The drug does not have mito-, antigenic features, a polyclonal effect.
Kinetics: maximum concentration
Using candles, tablets, putting injections "Polyoxidonium" (6 mg, 3 or 12 mg), the patient provides the intake of azoximeric bromide. With rectal administration, the substance is characterized by a high level of bioavailability - more than 70%. The maximum concentration in serum is achievable in about an hour. The duration of the half distribution is estimated at 30 minutes. There is no cumulative effect.
When using powder for solution preparation and injective administration, the drug on average reaches its maximum concentration in the circulatory system after 40 minutes. The bioavailability when introduced into muscle tissue exceeds 90%. The active compound is soon distributed over organic tissues, seeps through the blood-brain, blood-brain barriers.
If the patient receives Polyoxidonium tablets (6 mg not, only 12 mg, but the children are prescribed half a capsule at a time), the active ingredient is absorbed during passage of the gastrointestinal tract. Bioavailability is estimated to exceed 70%. The maximum concentration in serum is observed approximately three hours after administration. The kinetics of the drug is linear, corresponds to the received volume.
Kinetics: Duration of Excretion
Using powder for injections, suppositories, Polyoxidonium tablets (6 mg and other options), the patient receives azoximer bromide. A substance in the human body undergoes hydrolysis. The products of this reaction are oligomers derived mainly by the renal system. The elimination half-life is estimated at an average of 36.2 hours.
When will it help?
Prescribe suppositories, tablet form, injections "Polyoxidonium" (6 mg and other doses), if the patient has a weak immunity. The tool is used as an element of a comprehensive treatment. Prescription of the drug for children over six months of age is allowed. For the tablet form, the minimum age limit is three years, and for suppositories - six years. Consider the indications for the appointment of different forms separately.
Tablets
In this embodiment, "Polyoxidonium" is prescribed for the treatment and prevention of acute chronic respiratory diseases. The tool is used at the stage of remission and during relapse. As an element of a comprehensive treatment, Polyoxidonium tablets are prescribed for the acute form, relapse of a chronic infection, inflammation of the oropharynx, sinuses of the nose, respiratory tract (all zones), ear (middle, inner). "Polyoxidonium" is an element of the complex therapy of allergic diseases, the complication of which is the invasion of the fungus, bacteria, virus. This is possible with hay fever, in case of asthma.
"Polyoxidonium" for monotherapy in tablet form is used to prevent a recurrent herpes infection localized in the nose, labial. The drug prevents exacerbation of chronic sinus infections in the nose, respiratory tract, ear, oropharynx. Pills act as a reliable prevention of secondary immunity deficiency due to aging or external aggressive factors.
Suppositories
Polyoxidonium suppositories (6 mg, 12 mg) approved for adults and children are used to correct immune weakness. Indications are acute infection with viruses, bacteria, fungi, a recurrent chronic infection, inflammatory foci, when standard treatment does not give the desired effect. You can use candles in the acute stage or during remission. Suppositories are prescribed for tuberculosis, inflammatory urogenital pathologies, autoimmune diseases, the complication of which is an infectious syndrome caused by prolonged use of immunosuppressants. Candles "Polyoxidonium" is used for the aggravated course of acute respiratory viral infections, acute respiratory infections, against the background of allergic diseases, weighted by fungi, viruses, bacteria. The drug is prescribed to weaken the effects of drugs toxic to the liver and kidneys, to partially or completely rehabilitate people who are seriously ill, and activate regeneration. The product is used for chemotherapy, radiation, and also after such a course.
Monotherapy with suppositories Polyoxidonium (6 mg, 12 mg) is indicated to prevent recurrence of herpes disease, acute respiratory infections, influenza, relapse of the activity of a chronic infectious focus. Prescribe a drug to correct a secondary lack of immunity due to age and aggressive external factors.
Lyophilisate: indications
In the form of a powder for the preparation of the injectable drug βPolyoxidoniumβ (6 mg, 3 mg, 12 mg) is used for children from six months of age. As the only treatment, the drug is used to prevent acute respiratory viral infections, influenza, complications in the form of infection after surgery. As an element of a comprehensive course, a pharmaceutical product is used for intestinal dysbiosis, atopic dermatitis with foci of suppuration, asthma, accompanied by chronic infection. The tool is used to treat acute toxic, allergic, combined reactions, weighted by bacteria, viruses, fungi. Indications are inflammatory diseases (chronicles, acute) of various localization options, if the pathogen is a bacterium, virus, fungus.
Injections are prescribed for children as an element of complex treatment in cases of recurrence-prone chronic infection, inflammation of various localization options, bacterial infection, acute viral invasion affecting the ENT system. "Polyoxidonium" is indicated for gynecological, urological, allergic pathologies, it is prescribed for malignant disease, it is used during or after the main course of treatment with radiation, chemotherapy. Polyoxidonium injections (6 mg and other forms) are recommended for the prevention of systemic infection during surgery, for the treatment of this condition. The drug activates regenerative processes. They resort to it for pulmonary tuberculosis, arthritis, weighted by viruses, bacteria, fungi, if the disease occurs against the background of prolonged use of immunosuppressants.
Sometimes you canβt
The drug can not be used with individual susceptibility to the ingredients of the drug. The medicine is prohibited against the background of acute renal failure. In case of chronic weakness of the kidneys, you should use the drug twice a week or less, carefully monitoring the condition of the body. The pharmaceutical product is not prescribed for pregnant, lactating women. A contraindication for use is the age: under six months for injections, under three years for tablets, under six years for suppositories.
Unwanted effects
No side effects have been reported for tablets. If there is a suspicion of the formation of such, you need to urgently consult a doctor.
It is known that the use of Polyoxidonium suppositories (6 mg and twice as much saturated release) may be accompanied by local reactions - skin redness, swelling and itching of the area near the anus. Vaginal itching is possible. This is due to the individual susceptibility of the ingredients of the product.
When using the injective form, soreness of the injection site, redness of the integument, and the appearance of densified zones are possible. Extremely rarely observed increase in temperature in people who received injections, up to 37.3 degrees. Occasionally, anxiety, chills that disturbed the first hour after receiving the drug were recorded. There is a danger of an allergic reaction.
Opinions and prices
If you turn to specialized resources, magazines devoted to the collection of responses, you can find a lot of reviews about "Polyoxidonium" (6 mg and other dosage options). Mostly people who used the product under the supervision of a doctor were satisfied with the result. True, many noted that for their budget it was quite difficult.
On average, the price of Polyoxidonium (6 mg and other forms) varies about a thousand rubles. Much depends on the form, the amount of active ingredient in the sample, the volume of the product in the package, the cost policy of the point of sale. However, it is unlikely to buy a pack cheaper than 800 rubles. There are practically no prices above one and a half thousand for packaging. In most cities, goods are sold for about a thousand rubles per pack of candles, ampoules or tablets.
Instructions: how to use powder?
To learn how to dilute Polyoxidonium (6 mg, 3 or 12 mg), refer to the instructions that accompany the product. If at the disposal of a person a bottle containing 6 mg of the drug, the contents are combined with 1.5-2 ml of specially purified water prepared for injective administration. Alternatively, 0.9% sodium chloride can be used. After introducing a solvent into the pharmaceutical product, the preparation is kept for about three minutes to make the product swell, then mixed by gentle rotation, avoiding shaking. The resulting solution is used for intramuscular administration.
The instruction also describes how to dilute Polyoxidonium (6 mg and other forms) for injection, if it is necessary to administer the drug dropwise. The powder from one bottle is combined with a pair of milliliters of sodium chloride solution with a concentration of 0.9%. Introducing the solvent, allow the agent to swell for three minutes, then mix by rotating. The dosage shown to the patient, observing sterility, is introduced into a packet with 0.9% sodium chloride solution, after which the procedure is started.
Prepared solution is strictly prohibited to store.
Usage: in the nose, under the tongue
For children, 3 mg of the drug is combined with 20 drops of purified water or sodium chloride (0.9%). For twice the volume of the drug, you need to use 40 drops of liquid. You can use boiled water, the heating level of which corresponds to the air temperature in the room. One drop of the finished product contains 150 ΞΌg of the active ingredient.
For adults, 6 mg of the drug is combined with 20 drops of water or sodium chloride. The prepared liquid must be used within two days. It is necessary to store it in the manufacturer's packaging, under conditions of air warming up to the compact temperature level.
Using candles: standard layout
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