"Cerucal" is a drug that blocks dopamine receptors and allows you to weaken the sensitivity of the visceral nerves, which transmit impulses from the pylorus and duodenum to the vomiting center. The drug through the hypothalamus and the parasympathetic division of the nervous system regulates and coordinates the effect on the tone and activity of the gastrointestinal tract. It tones the intestines and stomach, helps to accelerate the emptying of the stomach, reduces the intensity of hyperacid stasis, prevents pyloric and esophageal reflux, activates intestinal motility. Reviews about "Cerucal" and instructions for use indicate that the drug is well tolerated by patients and does not adversely affect other organs. Next, we consider the indications for use, side effects and the treatment regimen.
Composition and form of release
The drug "Cerucal" is produced in tablet form and as a solution for injection. The solution can be administered intramuscularly or intravenously.
The instructions for use of Cerucal indicate that the active ingredient in its composition is metoclopramide in various dosages. In one tablet of the active substance - 10 mg, and in solution its concentration is 5 mg per 1 ml. The solution is packaged in 2 ml ampoules, so each of them contains 10 mg of the active component. Also in the composition of the drug there are additional substances:
- potato starch;
- lactose;
- gelatin;
- silica;
- magnesium stearate.
Cerucal tablets are white, round, flat in cardboard boxes, each containing 50 tablets. The solution for injection is presented in the form of a colorless liquid, in 2 ml ampoules, packed in cardboard boxes of 10 pieces. What form of drug to choose for therapy is determined by the doctor, taking into account the patient's condition and the severity of symptoms.
Therapeutic action "Cerucal"
What helps Tserukal? Instructions for use tell us that it has an antiemetic and anti-alicot effect. This effect is achieved by suppressing these reflexes at the central nervous system. All other effects of the drug are considered derived from the main ones.
The therapeutic effect of the drug is due to its penetration into the blood and brain, due to which dopamine and serotonin receptors are blocked in every organ and tissues of the human body. Due to the blocking of receptors located in the brain, its special zone, called the vomiting center, stops working, so irritants from the digestive and respiratory organs are not processed, which means that the gag reflex is not observed. And since the emetic center is also responsible for hiccups, hiccups and vomiting pass as a result.
In addition, due to the effect of the drug "Cerucal" (indicated in the instructions for use) on dopamine and serotonin receptors in the digestive system, the drug also has other therapeutic effects:
- Reduces contractile activity of the esophagus, which allows you to expand the lumen and facilitate the passage of food.
- Increases the tone of the sphincter of the esophagus.
- Accelerates the transition of food from the stomach to the duodenum, reducing the feeling of heaviness and discomfort.
- It increases the speed of food movement through the intestines, stimulating peristalsis, while not causing diarrhea.
- It normalizes the release of bile in response to the ingestion of food into the intestines.
- It normalizes the contraction of the gallbladder, eliminating its dyskinesia.
When should I take Tserukal?
The instructions for use of "Cerucal" noted that the drug must be taken in such cases:
- With attacks of nausea and vomiting, hiccups, regardless of what it provoked.
- With hypotension and atony of the gastrointestinal tract.
- Diabetic gastroparesis.
- Paresis of the stomach, especially in patients with diabetes.
- Flatulence, reflux esophagitis, biliary dyskinesia, functional pyloric stenosis.
- Duodenal sounding, which helps to accelerate the emptying of the stomach and the rapid movement of food through the small intestine.
- To enhance peristalsis during X-ray examinations of the stomach and intestines using a contrast medium.
- In the acute period of peptic ulcer of the stomach and duodenum as part of complex treatment.
The doctor should prescribe the drug.
Scheme of taking "Cerucal" in tablets
The dosage regimen for Cerucal medication for adults (indicated in the instructions for use) is selected by the attending physician. The standard scheme involves taking the medicine 1 tablet 3 times a day.
Cerucal tablets are taken on an empty stomach half an hour before meals. Drink the drug with plenty of water. The course of treatment is prescribed by the doctor, but according to the standard scheme, it can be from 1 to 2 months, depending on the diagnosis and the complexity of the course of the disease. In the most difficult cases, the course of therapy can be delayed up to 6 months.
Taking the drug is allowed for children from the age of two. The treatment regimen looks like this:
- From 2 to 14 years old for children with vomiting, the instructions for use of Cerucal recommends using a dosage of 0.1 mg per 1 kg of body weight, the daily amount should not be more than 0.5 mg of active substance per 1 kg of body weight. In the presence of kidney pathologies, the dosage is selected individually by the attending physician.
- Starting from the age of 14, the dosage can be increased to 10 mg, taken 3 times a day. The full course of treatment is from 4 weeks to one and a half months. Depending on the condition, the doctor may shorten the duration of therapy or increase it.
Scheme of using "Cerucal" in solution
Instructions for use "Cerucal" in ampoules says that the solution is administered intramuscularly and intravenously. Adults are recommended a dosage of 10 mg three times a day.
The medicine should be injected into the vein at a slow pace, about 15 minutes. It is allowed to enter the substance with a dosage of 0.5 mg per 1 kg of weight, but then the administration of the drug should last an hour.
Doctors do not recommend administering Cerucal in conjunction with other medications. Be sure to inform the attending doctor about the drugs that are currently being taken so that he eliminates the likelihood of side effects.
Side effects
The reviews and instructions for use with the Cerucal tablets state that they can cause unwanted manifestations on the part of various body systems:
- from the side of the heart and blood vessels there is an increase in blood pressure or its decrease, a violation of the heart rhythm;
- from the endocrine system, a menstrual cycle in women, gynecomastia or galactorrhea can occur;
- they can observe allergic reactions in the form of itching, hives and rashes on the skin;
- from the intestines and stomach, patients complain of dry mouth, constipation or diarrhea;
- from hemopoiesis, agranulocytosis is observed.
The central system suffers the most from side effects, headaches, dizziness, anxiety, drowsiness, depressive conditions, muscle cramps on the face, tinnitus and parkinsonism can be observed.
Instructions for use with Cerucal for children warns that increasing the dose can lead to an overdose. It is possible to identify its manifestations by the following symptoms:
- irritability appears;
- confusion of consciousness;
- heart rhythm is disturbed;
- jumps blood pressure;
- there may be cramps.
But as the reviews of patients who take the drug say, mild symptoms quickly disappear on their own without any treatment in a day, you just have to cancel the drug or replace it with a milder analogue in action. In more severe situations, symptomatic treatment will be required.
Contraindications to the reception of "Tserukal"
Instructions for use "Cerucal" says that the drug can not be used in such cases:
- with pheochromocytoma, since there is a risk of developing a hypertensive crisis, which causes the release of catecholamines;
- with prolactin-dependent neoplasm;
- with mechanical bowel obstruction;
- with bleeding in the stomach or intestines;
- with epilepsy;
- with glaucoma;
- during the first three months of pregnancy;
- during breastfeeding;
- children under the age of 2 years.
"Cerucal" is prescribed with caution to patients with impaired liver function, with arterial hypertension, hypersensitivity to procaine and children under the age of 14 years. In patients with impaired renal function, the drug is prescribed in a lower dose. Due to the fact that the drug contains sodium sulfite, it is not recommended to take it to patients with bronchial asthma and hypersensitivity to sulfite.
Cerucal during pregnancy
Doctors categorically prohibit the use of Cerucal injections and tablets (the instructions for use also warn about this) for women in the first trimester of pregnancy. In the second and third trimester, the drug is prescribed only if it is vital.
You can not use the medicine while breastfeeding. If you can’t do without it, then the woman should stop breastfeeding for the duration of therapy. Otherwise, the components of the drug can adversely affect the health of the baby.
Interaction with other drugs
If you are already taking any medications, before you start treatment with Cerucal, you need to know whether they are compatible with each other or not, so as not to harm your health.
For both children and adults, the instructions for the use of Cerucal tablets indicate that taking the drug with other drugs reduces its absorption rate. It accelerates the absorption of any antibiotics, as well as Ethanol and Paracetamol.
If you take it with anticholinergics, then the effect of the latter will be significantly reduced.
It is strictly forbidden to take "Cerucal" together with sedatives and antipsychotics.
It is very dangerous to combine the drug with alcoholic beverages.
Cerucal alters the effects of MAO inhibitors and drugs for depression.
The drug in the form of a solution accelerates the breakdown of vitamin B1 in the blood.
If the patient is taking other medications, then before starting treatment with Cerucal, he must definitely tell this to his doctor.
special instructions
The drug "Cerucal" in tablets is better for children not to be given if they are not yet 6 years old and the body weight has not reached 20 kg. For babies from 2 years of age, you can use the injection. But therapy should be carried out only in a hospital.
"Cerucal" is incompatible with alcohol, some potent drugs.
With prolonged intake of medication, you need to refrain from driving a car, controlling complex machinery.
In the first trimester of pregnancy, taking a drug to stop vomiting with toxicosis is prohibited. Its use can have a negative effect on the development of the fetus, provoke severe, and sometimes irreversible processes.
Analogues of the drug
If suddenly, for some reason, the patient can not take "Cerucal" with vomiting, (the instructions for use indicate possible causes), then the doctor selects an analog that has the same effect, but will be safer for the patient. Among analogues, it is especially possible to distinguish:
- "Metoclopramide";
- Brulium
- Domidon
- "Gastropom";
- Domperidone
- Motilium;
It should be remembered that side effects can cause not only tablets and injections of "Cerucal", instructions for use with analogues should also be carefully studied.
Reviews and price of the drug "Cerucal"
The drug "Cerucal" can be bought at any pharmacy without any restrictions. Its cost is small, the drug is available to every buyer, even a person with a minimum income. Packaging of ampoules is sold at 250-280 rubles, and 50 tablets cost approximately 140 rubles.
Already, many patients were able to test the effect of the drug on themselves and were satisfied with its therapeutic properties. Patients and doctors speak of the drug as the best and fastest drug that helps get rid of vomiting, hiccups and other unpleasant symptoms associated with malfunctions of the stomach and intestines.
Doctors say that the product is safe for health, easy to use and most importantly precisely acts on the cause. If you take the drug regularly, then after a day the abdominal discomfort disappears. Many medical professionals consider it to be the best tool that can effectively cope with vomiting, hiccups and many other symptoms.
Everyone can face an unpleasant symptom in the form of nausea and vomiting, it is important to have an effective drug at hand that will help get rid of it. To increase the therapeutic effect, it is necessary to strictly follow the attached instructions and be sure to inform the doctor about the side effects that have appeared.