"Polyoxidonium", 12 mg: release form, indications for use, instructions, composition, storage conditions

"Polyoxidonium" (12 mg) - a drug belonging to the pharmacotherapeutic group of immunomodulating agents. Such medicines are used in cases where it is required to help the body in the fight against pathogens. Treatment with the drug is carried out according to certain schemes. Consider them, as well as indications, contraindications and some other nuances associated with Polyoxidonium (12 mg).

Active ingredient and dosage forms

In this preparation, the main substance is azoximer bromide. The component is characterized by immunomodulatory, detoxifying, antioxidant and moderate anti-inflammatory effects.

"Polyoxidonium" in a dosage of 12 mg is available in two dosage forms. There are tablets for oral and sublingual administration and suppositories (suppositories), which can be used both rectally and vaginally. There are no other dosage forms available in a dosage of 12 mg.

Additional Information. Are there other dosages? In pharmacies, you can see 6 mg suppositories. This dosage form is specially formulated for children. A lyophilisate is also available, from which a solution for injection and topical application is prepared. Its dosage is also not 12 mg. "Polyoxidonium" in the form of a lyophilisate contains either 3 mg or 6 mg of active ingredient.

List of optional components

"Polyoxidonium" contains not only azoximer bromide, but also a number of excipients. The tablets contain lactose monohydrate, potato starch, mannitol, povidone, stearic acid. The list of excipients that make up the suppositories includes cocoa butter, mannitol, as well as povidone.

Pharmacodynamics of the drug

The main substance "Polyoxidonium" has a complex effect on the human body:

1. The immunomodulatory effect is to restore the functions of the immune system. This is necessary for various diseases (for example, for secondary immunodeficiency conditions provoked by infections, the appearance of cancer cells, injuries, postoperative complications, etc.).
2. The detoxifying effect of the drug is manifested in the removal of toxins, salts of heavy metals. When taking "Polyoxidonium" the human body is cleansed of those substances that it does not need and cause harm.
3. The antioxidant effect of the main substance of the drug is the inhibition of lipid peroxidation (LPO). What is it for? Lipid peroxidation can lead to negative consequences. The increase in lipid peroxidation products causes damage to proteins and lipids of biomembranes, a change in the structure of macromolecules, and a violation of the integrity of cells and intracellular organelles.
4. The anti-inflammatory effect of azoximer bromide is to reduce the inflammatory response due to the normal synthesis of pro- and anti-inflammatory cytokines.

Polyoxidonium (12 mg) is characterized by good tolerance. Azoximer bromide does not have a carcinogenic, mutagenic or embryotoxic effect. Allergic reactions are possible with the use of suppositories. At the same time, practice shows that undesirable effects are a rare phenomenon. Only a small proportion of people experience vaginal itching, itching of the perianal zone, swelling and redness of the skin. No side effects have been reported in the tablets.

Pharmacokinetics

Azoximer bromide quickly penetrates the mucous membranes and is distributed throughout the body. The maximum concentration of the active ingredient after taking the pill is reached after 3 hours, and after applying the suppository - after 1 hour.

Azoximer bromide in the body breaks down to low molecular weight oligomers. They are excreted mainly by the kidneys. A small proportion of oligomers (about 3%) falls into feces. The drug has no cumulative effect.

Indications for use "Polyoxidonium", 12 mg

Tablets. The tablet form of the drug is prescribed for adults and children over the age of 3 years. "Polyoxidonium" helps to cope with acute and chronic (during an exacerbation) infectious and inflammatory diseases of the oropharynx, upper and lower respiratory tract, paranasal sinuses, inner and middle ear. Also, the medicine is effective in the treatment of allergic diseases complicated by a recurring infection (bacteria, fungi or viruses). For all of the above indications, Polyoxidonium is used as part of complex therapy.

The drug is allowed to be used for preventive purposes. Monotherapy with 12 mg Polyoxidonium tablets prevents:

• exacerbation of chronic diseases of the oropharynx, upper and lower respiratory tract, paranasal sinuses, inner and middle ear;
• the development of herpetic infection in the lips or nose;
• the development of secondary immunodeficiency states due to the influence of negative factors on the body, due to aging.

Suppositories. "Polyoxidonium", produced in the form of suppositories of 12 mg, is suitable for the treatment and prevention of various infectious and inflammatory diseases in adults. In cases where the use of the drug for medicinal purposes is required, suppositories are prescribed in combination with other medicines. The list of indications is quite extensive:

• acute or exacerbated infectious and inflammatory diseases of different localization and etiology;
• various forms of tuberculosis;
• inflammatory diseases of the urogenital tract (prostatitis, pyelonephritis, cystitis, bacterial vaginosis, endomyometritis, etc.);
• Allergic diseases complicated by infection (bacterial, fungal or viral);
• oncological diseases ("Polyoxidonium" in cancer reduces the negative effects of chemo and radiation therapy);
• rheumatoid arthritis, proceeding against the background of prolonged use of immunosuppressants and complicated by any infection;
• burns and ulcers on the body, fractures (the active substance of the drug activates the recovery processes in the body).

Prevention with 12 mg Polyoxidonium suppositories can be carried out in order to prevent adults from developing acute respiratory infections, herpetic infections of the urogenital tract, and secondary immunodeficiency states. Also, the drug helps to prevent exacerbation of chronic infections. For prevention purposes, it is sufficient to use only Polyoxidonium suppositories without additional medications.

List of contraindications

At first glance, it may seem that Polyoxidonium is useful and safe. It strengthens the immune system and does not worsen well-being with side effects. However, Polyoxidonium is still a cure. In some cases, it cannot be used.

Pills and suppositories have several common contraindications:

• hypersensitivity to the components contained in the composition;
• the period of pregnancy and breastfeeding;
• acute renal failure.

Additionally, tablets are prohibited from treating and preventing rare hereditary lactose intolerance, lactase deficiency, glucose-galactose malabsorption syndrome. Also, this dosage form is not used in children under 3 years of age. Suppositories also have one additional contraindication. "Polyoxidonium" with 12 mg of active ingredient in this dosage form is not intended for use in childhood. For children, as mentioned above, special suppositories with 6 mg of azoximer bromide are released.

Caution in the use of "Polyoxidonium" must be observed in case of renal failure occurring in a chronic form. In this pathological condition, you must first consult a doctor. Specialists, as a rule, recommend that patients with chronic renal failure not to use tablets and suppositories more than 2 times a week.

Schemes for the use of tablets for medicinal purposes

For the tablet form, several application schemes are provided. You can find them in the table.

Therapeutic use of suppositories

Candles "Polyoxidonium" with 12 mg of active substance for any disease are used in the same doses. Vaginal administration of suppositories is indicated in the presence of any gynecological problems. The daily dose is 1 suppository. It is inserted into the vagina before bedtime. Rectal suppositories are also used 1 time per day after bowel cleansing.

Candlelight treatment may not be carried out every day. Features of therapy depend on the disease. With gynecological ailments, exacerbated infectious and inflammatory diseases that occur in a chronic form, treatment is carried out in two stages. The first stage is the first three days. During this period, suppositories are required to be administered daily. In the second stage, candles are applied every other day. In total, 10 suppositories should be spent during the treatment period.

Daily use of candles "Polyoxidonium" 12 mg is required:

1. In the presence of injuries, ulcers, burns, fractures (to activate recovery processes in the body), acute infectious processes. The course of treatment in such cases is 10 days.
2. With exacerbated urological diseases. The duration of use of suppositories is 10 days.
3. With allergic diseases that occur with infectious exacerbations. The duration of treatment is 10 days.

Special treatment regimens are provided for patients with the following diagnoses:

1. Pulmonary tuberculosis. For the first three days, suppositories are used daily, and then treatment is carried out every other day. The course includes 20 suppositories of 12 mg each. After treatment, maintenance therapy may be carried out for 2-3 months. Its essence is the use of suppositories 6 mg twice a week.
2. Oncological diseases. “Polyoxidonium” (12 mg) begins to be applied before chemo- and radiation therapy in 2-3 days. Suppositories are administered daily for 1 pc. After this, it is required to apply candles not daily. The scheme is twice a week, and the course is up to 20 suppositories.
3. Rheumatoid arthritis. With this diagnosis, suppositories are used every other day. The course of treatment involves the use of 10 candles.

The use of the drug for preventive purposes

The tablet form of release of Polyoxidonium (12 mg) is used sublingually for the prevention of various diseases. For adults, as a rule, 1 tablet per day is sufficient. Duration of use - 10 days. More frequent use of the drug (1 tablet twice a day) is necessary for the prevention of recurrent herpes, manifested in the lips and nose.

Pills can also be given to children for prevention. Application features can be seen in the table.

Certain schemes have been established for the use of suppositories for preventive purposes:

1. Suppositories with 12 mg of the active substance can help adults prevent the development of influenza and SARS. To do this, you need to enter the medicine daily (1 pc.) For 10 days.
2. In order to prevent exacerbations of various chronic diseases, urogenital herpes suppositories are used every other day. In total, the medicine should be administered 10 times.
3. Prevention of secondary immunodeficiencies provoked by aging is effective when using the drug 2 times a week. The course includes 10 suppositories. Such prophylaxis can be carried out 2 or 3 times a year.

Terms of purchase and storage

The medicine is over-the-counter, that is, it is freely sold in pharmacies. After buying it, it is important to pay attention to compliance with storage conditions. "Polyoxidonium" (12 mg) should be in a place where moisture does not get. Recommended storage temperature:

• for tablets - 2–25 degrees;
• for suppositories - 2-15 degrees.

The shelf life of Polyoxidonium is 2 years from the date of manufacture.

Reviews of immunologists about "Polyoxidonium"

Too many doctors give a positive assessment of "Polyoxidonium." According to experts, this drug is a pretty good immunomodulator. When used in complex therapy, it helps the body cope with emerging diseases faster. Another positive side of the drug is the ability to use "Polyoxidonium" for the prevention of ailments. The disadvantages of many doctors include only the price of the medication. On average, a package with tablets (10 pcs.) Costs 750 rubles, and a package with suppositories (10 pcs.) - 1,050 rubles.

There are also negative reviews of immunologists about Polyoxidonium. Specialists negatively related to the drug, claim that its clinical effectiveness is not proven. A few more negative opinions: this medicine was created only for making money by the manufacturer; the medicine is produced in Russia, in other countries no one knows about the existence of such a "miracle cure" that allows you to effectively deal with a wide range of ailments, ranging from influenza to bacterial vaginosis.

What can replace "Polyoxidonium"

If "Polyoxidonium" for some reason does not fit (for example, caused an allergy), then you can find a replacement. The group of immunomodulatory drugs combines many drugs. However, choosing something yourself is not recommended. Each immunomodulator has its own list of indications.

For example, you can cite "Lycopid" (the active substance is glucosaminylmuramyl dipeptide). This medication is available in pill form. It is used in complex therapy for treatment in adults and children from 3 years of age with chronic infections of the respiratory tract, herpes infections, acute and chronic purulent-inflammatory diseases of soft tissues and skin. Prevention "Likopidom" can only be carried out by adults in order to prevent the development of diseases of the respiratory tract, ENT organs.

Still can be attributed to analogues of "Polyoxidonium" (12 mg) candles "Genferon". This drug is a combined remedy, because it contains 3 active substances - interferon alpha, taurine, benzocaine. The first component has antimicrobial, antiviral and immunomodulatory effects. Taurine accelerates tissue regeneration processes, helps relieve inflammation, and benzocaine is a local anesthetic. This analogue of suppositories “Polyoxidonium” (12 mg) is used in the treatment of infectious and inflammatory diseases of the urogenital tract.

In conclusion, it is worth noting that Polyoxidonium has been on the pharmaceutical market for several years. If you study the reviews, you can understand that so many people have experienced the effect of this drug on themselves and were satisfied with its effectiveness. For all, the treatment was different - tablets, suppositories in accordance with the instructions for use, injections. "Polyoxidonium" with 12 mg, with 6 mg, and also with 3 mg of the active substance helped people quickly cope with existing ailments, strengthen immunity to prevent the occurrence of various diseases in the future.