Recently, in our country, Indian pills for hepatitis C are becoming more widespread. According to numerous reviews, they work perfectly at a relatively affordable price. It is relatively easy to order and receive such drugs, but they should be used only after talking with the doctor. Only a doctor can say exactly how reasonable the use of these drugs in a particular case will be. So, what are the good preparations from India and how to use them?
general information
Indian hepatitis C pills help cope with a serious inflammatory liver disease. It is provoked by a specific virus. The disease occurs in acute or chronic form. On average, 20% of patients are cured; in 80%, the disease transforms into a chronic one. To reduce the risks of this outcome, you need to start timely treatment. The course of the disease is determined by the nuances of the genotype. Doctors know six genotypes, of which the first three are most often found. All of them provoke severe hepatitis. The disease is established by detecting the presence of antibodies to the virus. If these particles are found, the diagnosis is considered confirmed. To determine if the virus is active or if the person is only a carrier, one needs to analyze the blood for the presence of IgM antibodies.
Hepatitis: disease and treatment
Since the disease is relatively common, treatment regimens have been developed that provide a reliable result to one degree or another. The classic course involves the use of ribavirin, interferon-alpha. The duration of the program sometimes exceeds 70 weeks. This is determined by the genotype and nuances of the flow. There are many drawbacks to such treatment, so patients are looking for alternatives. These were Indian pills for hepatitis C. It is believed that they are highly effective, do not provoke such an abundance of negative effects. Some doctors claim that the use of Indian drugs is associated with a greater likelihood of recovery. Medicines are considered analogues of American drugs. Other statistical reports indicate a cure rate of up to an impressive 97%.
What is this about?
Doctors may recommend Indian hepatitis C tablets sold under the names:
Both drugs have a direct antiviral effect. They work in conjunction with each other. It is believed that this is one of the best treatment options, since medications directly affect the virus, killing it. After several days from the beginning of the course, the patient's condition becomes better, and the concentration of harmful microorganisms decreases seven days after the start of therapy. The duration of treatment usually varies from 12 weeks to twice as long. The exact duration is determined by the genotype of the virus and the characteristics of the state of the human body in need of treatment. You cannot use these funds on your own, since intolerance is possible. They are prescribed by a hepatologist. He thinks out a scheme suitable for the type and severity of the case.
About the nuances
As can be concluded from the experience of doctors, Indian drugs for hepatitis C show a good result even in the case of an advanced stage of the disease. The above remedies are allowed for the treatment of persons suffering from kidney disease, drug dependence. They are prescribed against a background of fibrosis, cirrhosis. Although the negative effects are inherent in the remedies, their list is narrow and the incidence is small. It is known that some complained of headaches and weakness, joint and muscle soreness. True, it should be understood that the success of treatment is possible only with a combination of these two drugs. Without each other, they do not work.
What do patients say?
According to reviews, Indian hepatitis C tablets give a reliable effect. True, the opinions are mixed. Someone noted that these funds did not help them. Most of the responses were positive, but others who used the drugs thought it was a waste of money. Before checking the effectiveness of the compounds on a specific patient, it is imperative to consult a doctor. It is also important to understand that human organisms are not identical, therefore, what suits one well is not applicable to the other. Although overall reviews of Indian hepatitis C tablets are positive, you must be aware of all the risks associated with treating the disease.
More details: Sofosbuvir
This Indian hepatitis C drug belongs to the category of prodrugs. Once in the human body, it transforms into the active molecule GS-461203, which can inhibit the RNA polymerase used by the disease virus to copy its RNA. When the patient takes the pill inside, the drug is absorbed into the digestive tract. The process takes place with absolute efficiency. In blood serum, the maximum content is recorded after 30-60 minutes. The level of entry in connection with plasma proteins is 65%. The therapeutic effect is observed immediately after the start of the course. The product is processed by the liver and excreted in half a quarter of an hour. The main route of excretion is the intestines.
When and how to take?
“Sofosbuvir” is the name of Indian hepatitis C tablets for use in identifying a chronic form of the disease. The drug is prescribed for genotypes one to four. It can be used as an element of complex treatment. This medication should not be prescribed to pregnant and lactating mothers and minors. It is necessary to remember the risk of individual intolerance. This is also a contraindication. If there are no restrictions, the drug is prescribed for oral administration once a day. A single dose is 0.4 g. The maximum daily and maximum allowable single dose is also 400 mg. Duration of admission is 12 weeks.
Possible unpleasant consequences
Indian hepatitis C tablets under consideration can cause peripheral edema and fainting. It is known that some had shortness of breath, others were worried about hypothyroidism. There is a risk of retinopathy, although the likelihood is very small. There is a risk of dyspepsia and diarrhea, as well as lymph, leuko, thrombocytopenia. The reactions of rash and hypersensitivity to ultraviolet were recorded. There is a danger of allergies.
Interaction
When treating hepatitis with Indian Sofosbuvir tablets, it must be remembered that the effectiveness of this agent decreases under the influence of Rifampicin. The effect of Sofosbuvir is potentiated with the use of Ritonavir. The combination with Indinavir may cause an increase in bilirubin in the blood. The combination with "Irinotecan" leads to a greater poisoning ability of this drug due to a slowdown in processing in the body. Warfarin is stronger, so there is a risk of bleeding, and the effectiveness of Saquinavir is falling. The absorption of tablets becomes lower when taking antacids. Hormonal contraceptives work worse if they contain estradiol. The content of Sofosbuvir in the blood serum is reduced if the patient takes H2-nystamine receptor blockers or proton pump inhibitors. Sofosbuvir potentiates the effect of Quinidine, Diltiazem. The same is observed when combined with Lidocaine, Amiodarone.
Features and Overdose
When treating hepatitis C with the Indian drug Sofosbuvir, you need to remember that it should be prescribed to people over 65 years of age only with the possibility of constant monitoring of the patient's condition. Severe renal failure requires special care. The product is included in category C on the FDA scale, which indicates the impossibility of its use when carrying and breastfeeding a child. If the need for treatment of hepatitis occurs in a man whose partner is pregnant, he should also refrain from the medication in question. There were no cases of overdose, but in such a situation the patient needs therapy based on non-appearing symptoms. The manufacturer recommends a very thorough titration of volumes of drugs that inhibit the conductivity of calcium channels, if they are prescribed to a person who needs a course of Sofosbuvir. Mandatory control ECG.
In details: Daclatasvir
If you believe the reviews, Indian hepatitis C drugs work well only in combination, that is, Sofosbuvir must be supplemented with Daclatasvir. This antiviral agent was developed by BMS and is recognized as an innovative approach to the treatment of hepatitis. Initially, the patent was filed for Ducklins. It is quite expensive, but several drugs with a similar active ingredient and at a lower price are available on the pharmacy market. The peculiarity of Daclatasvir is that it can affect the NS5A protein. This is an unstructured object, due to which the disease is difficult to treat with interferons. In fact, this protein is what makes the disease so stubbornly resists human immunity. "Daclatasvir" slows down and completely inhibits the generation of this protein, blocks the spread of the virus already in the body. Due to this, the Indian drug Daclatasvir, intended for the treatment of hepatitis C, prevents the infection of healthy cells. This effect is observed in the treatment of hepatitis C of any known genotype.
Terms of use
Indian-made drugs that help against hepatitis C, like any other medication, are prescribed by a doctor and are used only under the supervision of a doctor. Self-treatment by them is unacceptable. First, the doctor prescribes laboratory tests to confirm the diagnosis, then determines the contraindications and restrictions on admission, formulates the rules and course, develops a system of control checks. An individual approach is the key to successful treatment. Daclatasvir is intended for oral administration. The tablet is consumed whole without crushing or chewing. After administration, drink the product with a small volume of water. A medicine is used once a day. You need to develop a schedule for taking pills and adhere to a stable time. Daclatasvir is used with meals or immediately after.
Dates and Doses
The Indian drug for hepatitis C "Daclatasvir" is used per day in the amount of 60 mg. If the patient missed the reception, you can not make up for it by using a double dose, otherwise there is a danger of an overdose. In rare cases, the doctor reduces the daily norm to half the standard. This is due to the characteristics of the condition and the combined use of different drugs. The duration of the course reaches 3-6 months. If it was not possible to achieve a stable result, the doctor cancels the remedy due to an individual reaction of inefficiency.
Features
At the age of 65 years and older, patients can take Daclatasvir under the supervision of a doctor. Special dose adjustments are not required. Avoid the use of antacids that lower the effectiveness of the drug. No alcohol.
"Daclatasvir" is always prescribed in combination with other drugs. In addition to the above Sofosbuvir, you can compose the drug with Peginterferon, Ribavirin.
The rules of combination treatment
The doctor chooses the features of the scheme based on the genotype of the disease. It is necessary to check for liver diseases, to establish whether hepatitis treatment was previously carried out and what results it yielded. Daclatasvir monotherapy is ineffective. It can be used in combination with Sofosbuvir. If there is no hepatic cirrhosis, at the first and fourth genotypes, 60 mg of the first and 400 mg of the second drug are prescribed for a three-month period. If drugs to block the NS3 / 4A protein have already been used before, the course can be extended by a factor of two.
With the first and fourth genotypes and the first step of cirrhosis, it is reasonable to use the same combination for six months. If before there was no therapy, if the viral activity is low, you can halve the duration of the program. At a late stage of cirrhosis, the first and fourth hepatitis genotypes are treated with a semi-annual combination of “Daclatasvir”, “Sofosbuvir”, “Ribavirin”.
About schemes more
With the third genotype of the disease and compensated hepatic cirrhosis, it is also necessary to combine these three drugs. This course is indicated if the patient previously received treatment for hepatitis, but it did not give results. The duration of using three funds at the same time is six months.
The same amount of treatment is needed for the fourth genotype of the disease, combining Daclatasvir with Peginterferon-alpha, Ribavirin. The doctor can prescribe the last two funds in a course lasting a year. Typically, a virological reaction can be seen at weeks 4–11. If this is recorded, the duration of the use of auxiliary medicines is reduced to three months. If the virus disappears in the blood samples by the 12th week, it is necessary to extend the period of taking Daclatasvir to one year.
Contraindications
You can not appoint Daclatasvir to minors, since there have been no studies proving the effectiveness and safety of the medicinal composition for such a group of patients. You can not prescribe a remedy when a reaction of individual tolerance appears. Any of the components of the drug can provoke this. There is a danger of increased susceptibility to lactose. Do not prescribe Daclatasvir to a pregnant or breastfeeding woman. With treatment, conception is strictly prohibited. The ban lasts for five weeks after the end of the drug program. It is necessary to use contraceptives.
Cirrhosis of the liver, transplantation of this organ may be a contraindication for taking Daclatasvir. The decision will be at the discretion of the lead doctor. The effectiveness of the drug decreases if the patient consumes St. John's wort and drugs containing phenobarbital, rifampicin, rifabutin. The same effect is observed when combined with "Oxcarbazepine", "Carbamazepine", "Dexamethasone".