The article discusses the preparation "Predizin" instructions for use and reviews.
The drug is one of the antihypoxants prescribed for coronary heart disease. Its main therapeutic substance, trimetazidine, actively affects the activity of the heart muscle: it improves the condition of channels, cells and metabolic processes that occur in them.
Drug characteristics
According to the instructions for use of Predisine, the active substance, trimetazidine, produces an antihypoxic effect. Directly acting on brain neurons and cardiomyocytes, it optimizes their functioning and metabolism. The cytoprotective effect is caused by an increase in the energy potential, rationalization of oxygen consumption (the blockade of oxidation of fatty acids and aerobic glycolysis become stronger), activation of oxidative decarboxylation.
The drug supports myocardial contractility, prevents a decrease in the intracellular content of phosphocreatine and ATP. Under conditions of acidosis, the activity of ionic membrane channels normalizes, prevents the accumulation of sodium and calcium ions in cardiomyocytes, and establishes an intracellular concentration of potassium ions. Reduces acidosis within the cell and excessive phosphate levels, which is caused by reperfusion and myocardial ischemia. It prevents the damaging effect of free radicals and the activation of neutrophils in the area of ischemia, helps to maintain the integrity of cell membranes, increases the duration of the electric potential, and also reduces the output of CPK cells and the severity of ischemic myocardial defects. So it is said in the instructions for use to "Predizin". Reviews cardiologists consider at the end of the article.
With angina pectoris reduces the frequency of seizures, the need to use nitroglycerin. The body's tolerance to physical activity increases after two weeks of treatment, the contractile activity of the left ventricle in patients with ischemic dysfunction improves, and the pressure drops decrease.
Tinnitus and dizziness are reduced. With vascular eye disease, the functioning of the retina improves.
The drug easily crosses the histohematological barrier (GBS), is well distributed in the heart tissues. It is mixed with blood plasma by sixteen percent, 60% of the drug is excreted unchanged.
It is excreted from the body with urine seven hours after ingestion. In patients of retirement age, the elimination period takes almost twelve hours. What else does the application instruction for Predizin tell us?
The form of release of the drug and its composition
The drug is produced in tablet form, in an aluminum blister pack. The tablets are round in shape, pinkish in color. There are six blisters in the package, as well as instructions for use. One blister includes ten tablets. Instructions for use with Predizin tablets are very detailed.
The drug has the following composition:
- the active ingredient is trimetazidine dihydrochloride;
- additional components: E 572, fumed silica, alpha-starch, hypromellose, MCC;
- film coating: Opadry II 85G24057 (talc, PVA, E 172, titanium dioxide, E 322, polyethylene glycol).
This is confirmed by the instructions for use with Predizin (35 mg).
In what cases is it taken?
The drug is prescribed to:
- prevention and reduction of the frequency of angina attacks;
- ischemic conditions (hearing impairment, frequent dizziness, buzz in the ears).
In accordance with the instructions for use, "Predizin" is taken orally two or three times a day, one tablet with a meal, in the morning and evening.
The duration of the treatment course is determined by a specialist.
Drug Interactions and Possible Side Symptoms
It is undesirable to take a medication simultaneously with drugs that are intended to cleanse the human body, that is, with sorbents.
As indicated by the instructions for use, "Predizin" in most cases is well tolerated by patients, however, in some situations, the following side symptoms may appear during treatment with the drug: discomfort and pain in the abdomen, digestive disorders and stool disorders, migraine, nausea, dizziness, skin rash, itching of the skin, state of lethargy and weakness, flushing of the face, trembling of the upper and lower extremities, decreased muscle tone.
Side effects are observed at the very beginning of the use of the drug, in the process of choosing the appropriate dose, pass after a few days.
All the symptoms mentioned above are individual, their occurrence is determined by the specifics of the patient's body and the state of health.
Contraindications
The drug is contraindicated in:
- minority of the patient;
- individual intolerance to the components that make up the medication;
- periods of breastfeeding and gestation.
Pregnancy
There is no information on the safety of the medicinal product for the treatment of pregnant patients and during breastfeeding. The drug is not recommended for use by lactating and pregnant women.
Is an overdose possible?
There were no cases of overdose with this medication. After using a dose that exceeds the permissible, you need to go to a specialist as soon as possible.
special instructions
According to the instructions for use, the medicine “Predizin” is not used for the relief of angina attacks and for the initial treatment of myocardial infarction or unstable angina. You can not use the drug at the stage of prehospital therapy or on the first day after hospitalization.
Angina pectoris requires a reassessment of the coronary vessels, the study of treatment (with medication, as well as the possibility of revascularization).
The active substance can cause or worsen the signs of parkinsonism (muscle hypertonicity, akinesia, tremor), so patients, especially the elderly, need to be examined regularly. In doubtful situations, patients should be referred to a neurologist for a special examination.
If movement disorders such as signs of parkinsonism, tremor, restless legs syndrome, gait instability appear, stop using the drug. Such symptoms rarely appear, most often disappear after drug withdrawal. In most patients, the symptoms disappear completely no later than four months after the cessation of treatment with Predizin. If they are stored for more than four months after cancellation, a neurologist consultation is required.
Falls caused by arterial hypotension or an unstable gait can occur, in particular, in patients using antihypertensive drugs.
Care must be taken when using by patients if increased exposure of the drug is expected:
- with moderate renal impairment, patients from 75 years of age;
- since there is no clinical experience, it is undesirable to use with severe hepatic impairment.
Due to the content of soya lecithin in the preparation, patients with an allergy to peanuts or soy should not take the drug.
Analogs
The most common analogues are as follows:
- "Angias retard";
- "Trimetazidine MV-Teva";
- "Antisten";
- "Trimetazidine" in capsules;
- "Antisten MV";
- "Trimetazidine-Biocom";
- "Vero-Trimetazidine";
- "Trimetazidine-Teva";
- "Deprenorm MV";
- "Trimetazidine";
- "Preductal MV";
- "Trimectal MV";
- "Rimekor MV";
- "Triducard MV";
- "Rimekor";
- "Triducard";
- "Rimekor MV".
A remedy with a similar effect can only be selected by a specialist.
Reviews of cardiologists and patients
Specialists prescribe Predizin and recommend that patients maintain a healthy lifestyle (bring their weight back to normal, lower cholesterol, eat right and move more). In this case, the treatment will be effective.
Patients respond to the drug both positively and negatively. They talk about the rapid effect of the drug, at an affordable cost. Negative reviews report side effects when taking the medicine.
The article discusses the "predizin" instructions for use and analogues.